Search

Now showing items 1-10 of 12

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

Jiang, Q.; Shi, D.; Nakajima, M.; Dai, J.; Wei, J.; Malizos, K. N.; Qin, J.; Miyamoto, Y.; Kamatani, N.; Liu, B.; Tsezou, A.; Nakamura, T.; Ikegawa, S. (2008)

A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the ...

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)

Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility

Chapman, K.; Takahashi, A.; Meulenbelt, I.; Watson, C.; Rodriguez-Lopez, J.; Egli, R.; Tsezou, A.; Malizos, K. N.; Kloppenburg, M.; Shi, D. Q.; Southam, L.; van der Breggen, R.; Donn, R.; Qin, J. H.; Doherty, M.; Slagboom, P. E.; Wallis, G.; Kamatani, N.; Jiang, Q.; Gonzalez, A.; Loughlin, J.; Ikegawa, S. (2008)

We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 ...

Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: A case-control study

Qin, J.; Shi, D.; Dai, J.; Zhu, L.; Tsezou, A.; Jiang, Q. (2010)

Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) ...

Replication studies in various ethnic populations do not support the association of the HIF-2 alpha SNP rs17039192 with knee osteoarthritis

Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2011)

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)

Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...

Meta-analysis of association between the ASPN D-repeat and osteoarthritis

Nakamura, T.; Shi, D.; Tzetis, M.; Rodriguez-Lopez, J.; Miyamoto, Y.; Tsezou, A.; Gonzalez, A.; Jiang, Q.; Kamatani, N.; Loughlin, J.; Ikegawa, S. (2007)

Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ...

Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand

Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)

Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

Kerkhof, H. J. M.; Meulenbelt, I.; Akune, T.; Arden, N. K.; Aromaa, A.; Bierma-Zeinstra, S. M. A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S. A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D. J.; Hauksson, V. B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U. M.; Lane, N. E.; Leino-Arjas, P.; Lohmander, L. S.; Luyten, F. P.; Malizos, K. N.; Nakajima, M.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T. D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A. E.; Tsezou, A.; Uchida, A.; Uitterlinden, A. G.; Wilkinson, J. M.; Yoshimura, N.; Valdes, A. M.; van Meurs, J. B. J. (2011)

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions ...

RECOMMENDATIONS FOR STANDARDIZATION AND PHENOTYPE DEFINITIONS IN GENETIC STUDIES OF OSTEOARTHRITIS: THE TREAT-OA CONSORTIUM

Kerkhof, H. J.; Meulenbelt, I.; Arden, N.; Cooper, C.; Doherty, M.; Felson, D.; Gonzalez, A.; Ikegawa, S.; Jiang, Q.; Jonsdottir, I.; Kujala, U.; Lane, N.; Leino-Arjas, P.; Lohmander, S.; Luyten, F.; Nevitt, M.; Slagboom, E.; Spector, T.; Stefansson, K.; Tamm, A.; Tsezou, A.; Wilkinson, J.; Yoshimura, N.; Valdes, A.; van Meurs, J. (2010)