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Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification
(2017)
Objectives Sepsis-3 definitions generated controversies regarding their general applicability. The Sepsis-3 Task Force outlined the need for validation with emphasis on the quick Sequential Organ Failure Assessment (qSOFA) ...
Differential effects of the two amino acid sensing systems, the GCN2 kinase and the mTOR complex 1, on primary human alloreactive CD4+ T-cells
(2016)
Amino acid deprivation activates general control nonderepressible 2 (GCN2) kinase and inhibits mammalian target of rapamycin (mTOR), affecting the immune response. In this study, the effects of GCN2 kinase activation or ...
Exercise-induced effects on UCP1 expression in classical brown adipose tissue: A systematic review
(2017)
Understanding the impact of regular exercise training on uncoupling protein 1 (UCP1) activity in classical brown adipose tissue (CBAT) is vital to our knowledge of whole-body thermogenic activity. The purpose of this ...
Uric acid and cellular and humoral alloimmunity
(2018)
[No abstract available]
Practical Recommendations for the Diagnosis and Medical Management of Stable Angina: An Expert Panel Consensus
(2019)
Stable angina affects a significant number of coronary artery disease patients, impairing their quality of life and worsening their prognosis. It manifests even despite a history of revascularization and is often poorly ...
Vascular Surgery in Unreal Times
(2020)
[No abstract available]
Interactome of obesity: Obesidome: Genetic obesity, stress induced obesity, pathogenic obesity interaction
(2017)
Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment ...
Renal biomarkers and outcomes in outpatients with heart failure: The Atlanta cardiomyopathy consortium
(2016)
Background/objectives Cystatin-C and beta-2-microglobulin may be superior to serum creatinine, blood urea nitrogen (BUN), or estimated glomerular filtration rate (EGFR) in patients hospitalized with heart failure (HF). We ...
Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation
(2016)
It is known that inadequate erythropoietin (EPO) production contributes to the pathogenesis of anemia of inflammation, although the exact molecular mechanism is unknown. Aryl hydrocarbon receptor (AhR) may compete with ...
Glycaemic control in heart failure: a PARADIGM shift for patients with concomitant diabetes?
(2017)
[No abstract available]