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P38 MAPK signaling in pemphigus: Implications for skin autoimmunity
(2013)
p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ...
Autoantibodies in autoimmune pancreatitis
(2012)
Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ...
Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases
(2015)
Background: The liver asialoglycoprotein receptor (ASGPR) is the only organ-specific autoantigenic target in autoimmune hepatitis (AIH) patients and corresponding autoantibodies (Abs) have been suggested aiding in the ...
Fetomaternal alloimmunity as a cause of liver disease
(2011)
Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ...
Hair dyes as a risk for autoimmunity: From systemic lupus erythematosus to primary biliary cirrhosis
(2013)
Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized ...
Towards systemic sclerosis and away from primary biliary cirrhosis: The case of PTPN22
(2012)
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium size intrahepatic bile ducts. PBC patients often have concomitant autoimmune ...
Primary biliary cirrhosis associated with systemic sclerosis: Diagnostic and clinical challenges
(2011)
Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The ...
PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis
(2010)
A dual isotype (IgG, IgA) enzyme-linked immunosorbent assay (ELISA) designed to provide enhanced detection of primary biliary cirrhosis (PBC)-specific autoantibodies against both major mitochondrial and nuclear antigens ...