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Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1
(2012)
In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat ...
Preparation of sirna-encapsulated plga nanoparticles for sustained release of sirna and evaluation of encapsulation efficiency
(2012)
Nanoparticles (NPs) formulated using poly (d,l-lactide-co-glycolide) (PLGA), a biodegradable, biocompatible, and clinically approved polymer, have been widely used for targeted drug delivery. Here we provide methods for ...
Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells
(2012)
Quercetin is a flavonol modifying a number of cell processes in different cell lines. Here, we present evidence that nonconjugated quercetin enters cells possibly via organic anion transporter polypeptides and quickly ...
Efficiency assessment across homogeneous specialty clinics in the region of thessaly, Greece
(2012)
Background: Hospital care expenditure is the most significant cost driver in the health care sector. Reductions in public hospitals' expenses are among the principal austerity measures included in the memorandum recommendations. ...
Role of endoscopic third ventriculostomy in treatment of selected patients with normal pressure hydrocephalus
(2012)
Objective: The purpose of our study was to evaluate the results of endoscopic third ventriculostomy (ETV) in the management of patients with idiopathic normal pressure hydrocephalus (INPH). Methods: Our prospective study ...
Synthesis and biological evaluation of 3′-c-ethynyl and 3′-c-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides
(2012)
A novel series of 3′-C-ethynyl and 3′-C-(1,4-disubstituted-1,2, 3-triazolo) double-headed pyranonucleosides has been designed and synthesized. Reaction of 3-keto glucoside 1 with ethynyl magnesium bromide gave the desired ...
Two-year mortality of patients with COPD in primary health care: An observational study
(2012)
Background: Chronic obstructive pulmonary disease (COPD) remains a significant cause of morbidity and mortality, with high rates of underdiagnosis. There are no studies about following up COPD patients in primary health ...
Human peripheral blood mononuclear cell culture for flow cytometric analysis of phosphorylated mitogen-activated protein kinases
(2012)
Lymphocyte activation and fine tuning of downstream signaling circuits for the regulation of cytokine expression are critical for a successful immune response. Hence, technical protocols permitting simultaneous testing of ...
Toll-like receptors and their role in renal pathologies
(2012)
Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. Expressed in immunocytes, TLRs initiate innate immune responses and concurrently shape the subsequent adaptive ...
Determinants of visitor pro-environmental intentions on two small greek islands: Is ecotourism possible at coastal protected areas?
(2012)
A relatively under-researched question is whether there is a possibility of influencing environmentally aware tourists regarding ecotourism at destinations that continue to develop under a pattern of mass 'seaside' tourism. ...