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Enzymatic conversion of dihydrotestosterone from 3-keto to 3-enol form in the rat prostate
(1996)
Dihydrotestosterone (DHT) is the active androgen, as well as a strong tumor promoter in the prostate, where several enzymes are essential for the regulation of its activity. We localized four enzymes promoting the enolization ...
CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside
(1999)
Signal transduction for apoptosis or programmed cell death, after DNA damage in mammalian cells, is believed to involve activation of cyclin-dependent kinases (CDKs), especially CDK-1 (cdc2) and CDK-2. We used CDK-inhibitor ...
Can traditional epidemiology detect cancer risks caused by occupational exposure to pesticides?
(1999)
In order to investigate the possible relationship between cancer and occupational exposure to pesticides, we reviewed the latest literature of the epidemiological studies in this area coming to the conclusion that, while ...
Sex-hormone binding globulin from sheep serum: purification and effects of pregnancy and treatment with exogenous estradiol
(1999)
Sex-hormone binding globulin (SHBG) is a protein that binds sex steroids in the serum of many species. SHBG binds androgens and estrogens in humans and primates with high affinity, but behaves as an androgen binding protein ...
CHARACTERIZATION OF THE PROTEIN PROTECTING RNA FROM ACID PRECIPITATION AND ITS EVALUATION AS TUMOR-MARKER IN GASTROINTESTINAL AND GYNECOLOGICAL CANCER
(1995)
In a previous study, we observed increased protective activity against acid precipitation of poly (U) in the serum of tumor bearing mice and hepatoma patients. In the present study we purified and partially characterized ...
Ribonucleases protect RNA from acid precipitation
(1997)
Four, widely used, ribonucleases were found to protect their substrates from acid precipitation by causing, evidently, a modification of their physicochemical properties. The protection was dependent on the kind of substrate ...