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Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis

Rigopoulou, E. I.; Mytilinaiou, M.; Romanidou, O.; Liaskos, C.; Dalekos, G. N. (2007)

Background. Non-organ specific autoantibodies are highly prevalent in patients with chronic hepatitis C (HCV). Among them, anti-liver kidney microsomal type 1 (LKM1) antibody - the serological marker of type 2 autoimmune ...

Fetomaternal alloimmunity as a cause of liver disease

Smyk, D.; Grammatikopoulos, T.; Daponte, A.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)

Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ...

Autoimmunity and Environment: Am I at risk?

Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)

The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ...

Ileal InflammationMay Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn's Disease

Pavlidis, P.; Romanidou, O.; Roggenbuck, D.; Mytilinaiou, M. G.; Al-Sulttan, F.; Liaskos, C.; Smyk, D. S.; Koutsoumpas, A. L.; Rigopoulou, E. I.; Conrad, K.; Forbes, A.; Bogdanos, D. P. (2012)

Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 ...

Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece

Mina, P.; Georgiadou, S. P.; Rizos, C.; Dalekos, G. N.; Rigopoulou, E. I. (2010)

AIM: To assess the hepatitis B virus (HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure (ESRF) patients from Central Greece. METHODS: Sera from 366 ESRF patients attending five out of six ...

Urinary tract infection as a risk factor for autoimmune liver disease: From bench to bedside

Smyk, D. S.; Bogdanos, D. P.; Kriese, S.; Billinis, C.; Burroughs, A. K.; Rigopoulou, E. I. (2012)

Autoimmune liver diseases include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis. A variety of environmental and genetic risk factors have been associated with these conditions. ...

Sex Differences Associated with Primary Biliary Cirrhosis

Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Billinis, C.; Burroughs, A. K.; Muratori, L.; Invernizzi, P.; Bogdanos, D. P. (2012)

Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to ...

Hepatitis E virus antibodies in hemodialysis patients: An epidemiological survey in central Greece

Stefanidis, I.; Zervou, E. K.; Rizos, C.; Syrganis, C.; Patsidis, E.; Kyriakopoulos, G.; Sdrakas, L.; Tsianas, N.; Rigopoulou, E. I.; Liakopoulos, V.; Dalekos, G. N. (2004)

Hepatitis E virus (HEV) is the causative agent for enteric non-A, non-B hepatitis. Transmission is mainly via the fecal-oral route but the possibility of an additional parenteric transmission has been raised. Patients ...

Twin studies in autoimmune disease: Genetics, gender and environment

Bogdanos, D. P.; Smyk, D. S.; Rigopoulou, E. I.; Mytilinaiou, M. G.; Heneghan, M. A.; Selmi, C.; Gershwin, M. E. (2012)

Twin studies are powerful tools to discriminate whether a complex disease is due to genetic or environmental factors. High concordance rates among monozygotic (MZ) twins support genetic factors being predominantly involved, ...

Tracing environmental markers of autoimmunity: introducing the infectome

Bogdanos, D. P.; Smyk, D. S.; Invernizzi, P.; Rigopoulou, E. I.; Blank, M.; Sakkas, L.; Pouria, S.; Shoenfeld, Y. (2013)

We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all ...

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