Now showing items 101-106 of 106
The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations
Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share ...
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease. Although additional missense variants were described, ...
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...
Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival
Restless legs syndrome (RLS) affects almost one out of three end-stage renal disease patients. This review assesses the current treatment options for uremic RLS and the potential benefits of those treatments on quality of ...
Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis
We present the first study on the influence of exercise training on restless legs syndrome (RILS) in patients on hemodialysis (HD). Restless legs syndrome has been treated pharmacologically with satisfactory results; ...