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Effects of the active constituent of Crocus sativus L. crocin on recognition and spatial rats' memory
(2007)
Crocus Sativus L. is a plant cultivated in various parts of the world. Its involvement in learning and memory processes has been proposed. The present study was designed to investigate in the rat the effects of the active ...
CB1R-dependent activation of Fyn tyrosine kinase and protein kinase C Delta, PKCδ, in lipid rafts
(2008)
Cannabinoid 1 receptors (CB1Rs) are heptahelical transmembrane receptors which may exert their effects through the activation of the extracellular signal-regulated kinases (ERKs). We have previously shown that stably ...
Transactivation of epidermal growth factor receptor EGFR by CB1 cannabinoid receptor agonists
(2007)
Cannabinoids have long been used as therapeutic agents. The recent identification of the endogenous cannabinoid system in the brain, namely the abundance of the CB1 receptor (CB1R) in the CNS and the discovery of the ...
Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat
(2006)
The effects of extracts of Crocus sativus L. (CSE), on memory were investigated in the rat by using the object recognition and the step-through passive avoidance task. In the first study, post-training administration of ...
PKC and Ras differentially regulate gene expression of the dopaminergic marker TH and noradrenergic marker DBH
(2007)
We have successfully established for the first time in the literature cell lines from human fetal cells derived from the amniotic fluid (AF) and have documented that these cells may progress and stably express many of the ...
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action
(2011)
The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is need to elucidate the mode of action of this compound as very ...