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Genome-wide association studies: hypothesis-"free" or "engaged"?
(2009)
The advent of the first wave of genome-wide association studies (GWAS) provided a new conceptual framework in the search for variants underlying common disorders: a massive scan of the genome, free from underlying assumptions ...
XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy
(2009)
Altered expression of the facilitated glucose transporter GLUT1 affects pathways implicated in the pathogenesis of diabetic nephropathy. There is indication that variation of GLUT1 gene (SLC2A1) contributes to development ...
Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis: The CUMAGAS-OSTEO Information System
(2010)
A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthntis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged ...
Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis
(2010)
The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of ...
Genomic Convergence of Genome-wide Investigations for Complex Traits
(2009)
Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ...