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Synopsis and Data Synthesis of Genetic Association Studies in Hypertension for the Adrenergic Receptor Family Genes: The CUMAGAS-HYPERT Database
(2010)
BACKGROUND The adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive ...
Randomized Trials of Dopamine Agonists in Restless Legs Syndrome: A Systematic Review, Quality Assessment, and Meta-Analysis
(2010)
Background: The use of dopamine agonists (DAs) for the treatment of restless legs syndrome (RLS) has been assessed in numerous randomized clinical trials (RCTs). Objectives: The aims of this study were to assess the reporting ...
Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis: The CUMAGAS-OSTEO Information System
(2010)
A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthntis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged ...
Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis
(2010)
The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of ...
An NOS3 haplotype is protective against hypertension in a caucasian population
(2010)
The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three ...
Lack of Association Between Common Endothelial Nitric Oxide Synthase Gene Haplotypes and Left Ventricular Hypertrophy in Hypertension
(2010)
The endothelial nitric oxide synthase (NOS3) gene has been implicated in the pathogenesis of hypertension-related left ventricular hypertrophy (LVH). Candidate-gene studies have examined the role of NOS3 variation, but ...