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Autoimmunity and Environment: Am I at risk?

Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)

The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ...

Anti-mitochondrial antibody immunofluorescent titres correlate with the number and intensity of immunoblot-detected mitochondrial bands in patients with primary biliary cirrhosis

Rigopoulou, E. I.; Bogdanos, D. P.; Liaskos, C.; Koutsoumpas, A.; Baum, H.; Vergani, D.; Dalekos, G. N. (2007)

Background: Primary biliary cirrhosis (PBC)-specific anti-mitochondrial antibodies (AMA), routinely detected by indirect immunofluoresnce, immunofix various mitochondrial antigens by immunoblot (IB). We have investigated ...

Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis

Rigopoulou, E. I.; Davies, E. T.; Bogdanos, D. P.; Liaskos, C.; Mytilinaiou, M.; Koukoulis, G. K.; Dalekos, G. N.; Vergani, D. (2007)

Background/Aims: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite ...

Disease-specific cross-reactivity between mimicking peptides of heat shock protein of mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis

Bogdanos, D. P.; Pares, A.; Baum, H.; Caballeria, L.; Rigopoulou, E. I.; Ma, Y.; Burroughs, A. K.; Rodes, J.; Vergani, D. (2004)

Previous studies on Spanish patients with Primary Biliary Cirrhosis (PBC) have shown extensive, disease-specific cross-reactivity between the 65-kDa heat shock protein (hsp65) of Mycobacterium gordonae and pyruvate ...

Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Koutsoumpas, A.; Polymeros, D.; Tsiamoulos, Z.; Smyk, D.; Karamanolis, G.; Triantafyllou, K.; Rigopoulou, E. I.; Forbes, A.; Vergani, D.; Bogdanos, D. P.; Ladas, S. D. (2011)

Background/aims: We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We ...

Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its lactobacillus mimic

Bogdanos, D. P.; Baum, H.; Okamoto, M.; Montalto, P.; Sharma, U. C.; Rigopoulou, E. I.; Vlachogiannakos, J.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2005)

The serological hallmark of primary biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antimitochondrial antibodies (AMAs). Anti-PDC-E2 antibodies cross-react specifically with ...

Association between the primary biliary cirrhosis specific anti-sp100 antibodies and recurrent urinary tract infection

Bogdanos, D. P.; Baum, H.; Butler, P.; Rigopoulou, E. I.; Davies, E. T.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2003)

Background and aims. Recurrent urinary tract infections (rUTI) have been suggested to be involved in the induction of anti-mitochondrial antibodies (AMA), the serological hallmark of primary biliary cirrhosis (PBC), in ...

Evidence that an E. coli replication primase peptide, highly homologous to the major sp100 epitope, is a possible trigger of anti-sp100 reactivity in primary biliary cirrhosis

Bogdanos, D. P.; Baum, H.; Butler, P.; Rigopoulou, E. I.; Ma, Y.; Burroughs, A. K.; Vergani, D. (2003)

Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus-infected patients is associated with the possession of HLA B51

Bogdanos, D. P.; Lenzi, M.; Okamoto, M.; Rigopoulou, E. I.; Muratori, P.; Ma, Y.; Muratori, L.; Tsantoulas, D.; Mieli-Vergani, G.; Bianchi, F. B.; Vergani, D. (2004)

Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected ...

Anti-gp210 antibody mirrors disease severity in primary biliary cirrhosis

Bogdanos, D. P.; Liaskos, C.; Pares, A.; Norman, G.; Rigopoulou, E. I.; Caballeria, L.; Dalekos, G. N.; Rodes, J.; Vergani, D. (2007)