Search

Now showing items 1-9 of 9

Fetomaternal alloimmunity as a cause of liver disease

Smyk, D.; Grammatikopoulos, T.; Daponte, A.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)

Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ...

Autoimmunity and Environment: Am I at risk?

Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)

The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ...

Hair dyes as a risk for autoimmunity: From systemic lupus erythematosus to primary biliary cirrhosis

Smyk, D.; Rigopoulou, E. I.; Bizzaro, N.; Bogdanos, D. P. (2013)

Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium sized ...

Peculiar antibody reactivity to human connexin 37 and its microbial mimics in patients with Crohn's disease

Koutsoumpas, A.; Polymeros, D.; Tsiamoulos, Z.; Smyk, D.; Karamanolis, G.; Triantafyllou, K.; Rigopoulou, E. I.; Forbes, A.; Vergani, D.; Bogdanos, D. P.; Ladas, S. D. (2011)

Background/aims: We found that pooled Crohn's disease (CD) sera strongly react with a human gap-junction connexin 37 (Cx37) peptide and tested for anti-Cx37 antibody reactivity in sera from CD patients and controls. We ...

PBC triggers in water reservoirs, coal mining areas and waste disposal sites: From Newcastle to New York

Smyk, D.; Mytilinaiou, M. G.; Rigopoulou, E. I.; Bogdanos, D. P. (2010)

Various environmental factors have been proposed as triggers of primary biliary cirrhosis (PBC), a progressive autoimmune cholestatic liver disease which is characterised by the destruction of the small intrahepatic bile ...

Infectious triggers of primary biliary cirrhosis: Do we know enough?

Smyk, D.; Rigopoulou, E. I.; Zen, Y.; Koutsoumpas, A.; Baum, H.; Bogdanos, D. P. (2011)

Primary biliary cirrhosis (PBC) is an immune mediated liver disease directed against the biliary epithelial cells of the small bile ducts. The disease is characterised by circulating antimitochondrial antibodies (AMA), as ...

Human peripheral blood mononuclear cell culture for flow cytometric analysis of phosphorylated mitogen-activated protein kinases

Mavropoulos, A.; Smyk, D.; Rigopoulou, E. I.; Bogdanos, D. P. (2012)

Lymphocyte activation and fine tuning of downstream signaling circuits for the regulation of cytokine expression are critical for a successful immune response. Hence, technical protocols permitting simultaneous testing of ...

Role for mycobacterial infection in pathogenesis of primary biliary cirrhosis?

Smyk, D.; Rigopoulou, E. I.; Zen, Y.; Abeles, R. D.; Billinis, C.; Pares, A.; Bogdanos, D. P. (2012)

Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized by the immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterized by ...

Primary biliary cirrhosis: Family stories

Smyk, D.; Cholongitas, E.; Kriese, S.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)

Primary biliary cirrhosis (PBC) is a chronic immune-mediated cholestatic liver disease of unknown aetiology which affects mostly women in middle age. Familial PBC is when PBC affects more than one member of the same family, ...