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Crohn's disease-specific anti-CUZD1 pancreatic antibodies are absent in ruminants with paratuberculosis

Liaskos, C.; Spyrou, V.; Athanasiou, L. V.; Orfanidou, T.; Mavropoulos, A.; Rigopoulou, E. I.; Amiridis, G. S.; Shoenfeld, Y.; Billinis, C.; Bogdanos, D. P. (2015)

Background: Pancreatic autoantibodies (PABs) specifically recognizing GP2 and/or CUZD1 are present in more than 35% of patients with Crohn's disease (CrD). We have recently provided evidence of the presence of GP2-specific ...

P38 MAPK signaling in pemphigus: Implications for skin autoimmunity

Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Spyrou, V.; Sakkas, L. I.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)

p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ...

The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis

Mavropoulos, A.; Rigopoulou, E. I.; Liaskos, C.; Bogdanos, D. P.; Sakkas, L. I. (2013)

The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic ...

HELICOBACTER PYLORI AS A TRIGGER OF SYSTEMIC SCLEROSIS: IMMUNOLOGICAL ASPECTS

Liaskos, C.; Varna, A.; Simopoulou, T.; Mavropoulos, A.; Mytilinaiou, M.; Rigopoulou, E. I.; Bogdanos, D. P.; Sakkas, L. I. (2014)

CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases

Liaskos, C.; Rigopoulou, E. I.; Orfanidou, T.; Bogdanos, D. P.; Papandreou, C. N. (2013)

CUZD1, the CUB, and zona pellucida-like domains-containing protein 1, is a newly identified antigen of pancreatic autoantibodies (PAB) giving a reticulogranular pattern in patients with inflammatory bowel diseases, and in ...

Autoantibodies in autoimmune pancreatitis

Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)

Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ...

Immunopathogenesis of primary biliary cirrhosis: an old wives' tale

Smyk, D. S.; Rigopoulou, E. I.; Lleo, A.; Abeles, R. D.; Mavropoulos, A.; Billinis, C.; Invernizzi, P.; Bogdanos, D. P. (2011)

Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progress to fibrosis ...

Fetomaternal alloimmunity as a cause of liver disease

Smyk, D.; Grammatikopoulos, T.; Daponte, A.; Rigopoulou, E. I.; Bogdanos, D. P. (2011)

Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ...

Autoimmunity and Environment: Am I at risk?

Smyk, D.; Rigopoulou, E. I.; Baum, H.; Burroughs, A. K.; Vergani, D.; Bogdanos, D. P. (2012)

The complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological ...

Ileal InflammationMay Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn's Disease

Pavlidis, P.; Romanidou, O.; Roggenbuck, D.; Mytilinaiou, M. G.; Al-Sulttan, F.; Liaskos, C.; Smyk, D. S.; Koutsoumpas, A. L.; Rigopoulou, E. I.; Conrad, K.; Forbes, A.; Bogdanos, D. P. (2012)

Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 ...

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