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Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Antoniadis, N.; Liakopoulos, V.; Stefanidis, I. (2013)

Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ...

Rapid effect of dexamethasone on the permeability of visceral sheep peritoneum

Karioti, A.; Hatzoglou, C.; Zarogiannis, S.; Deligiorgi, T.; Liakopoulos, V.; Kourti, P.; Giannopoulou, M.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2008)

The peritoneal mesothelium is a biologic barrier to water and ion transport. Its functional and structural integrity is crucial for peritoneal dialysis treatment. In vivo studies have shown that corticosteroids increase ...

Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Golfinopoulos, S.; Liakopoulos, V.; Mamara, A. M.; Speletas, M.; Koukoulis, G.; Stefanidis, I. (2013)

Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1β (IL-1β). Purinergic receptor P2X7 ...

Effect of cimetidine on the electrophysiologic profile of isolated visceral sheep peritoneum

Liakopoulos, V.; Zarogiannis, S.; Kourti, P.; Hatzoglou, C.; Karioti, A.; Arampatzis, S.; Giannopoulou, M.; Musso, C.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2009)

The peritoneal mesothelium is a barrier to ion transport in peritoneal dialysis. Cimetidine is an H2 receptor antagonist and a potent inhibitor of Na+/H+ antiporter, which is found in the plasma membranes of various cell ...

Endothelin-1 Acutely Reduces the Permeability of Visceral Sheep Peritoneum In Vitro Through Both Endothelin-A and Endothelin-B Receptors

Kourti, P.; Zarogiannis, S. G.; Liakopoulos, V.; Karioti, A.; Eleftheriadis, T.; Hatzoglou, C.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2013)

Mesothelium is an important part of the peritoneal barrier for water and ion transport, essential for effective peritoneal dialysis (PD). Peritoneal fibrosis has been associated with PD treatment failure. Endothelin-1 ...

Uric acid induces caspase-1 activation, IL-1 beta secretion and P2X7 receptor dependent proliferation in primary human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Golfinopoulos, S.; Liakopoulos, V.; Mamara, A.; Speletas, M. M.; Koukoulis, G.; Stefanidis, I. (2013)

The Indoleamine 2,3-dioxygenase Inhibitor 1-methyl-tryptophan Suppresses Mitochondrial Function, Induces Aerobic Glycolysis and Decreases Interleukin-10 Production in Human Lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I. (2012)

Background: Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. It is known that IDO induces T-cell differentiation to regulatory T-cells (Treg) through tryptophan depletion and/or kynurenine pathway products. ...

Spironolactone increases permeability of visceral sheep peritoneum

Karioti, A.; Hatzoglou, C.; Zarogiannis, S.; Deligiorgi, T.; Kourti, P.; Giannopoulou, M.; Arampatzis, S.; Liakopoulos, V.; Gourgoulianis, K.; Molyvdas, P. A.; Stefanidis, I. (2009)

Aldosterone is a key component of the renin-angiotensin-aldosterone system, and spironolactone, an aldosterone receptor blocker, shows beneficial effects in patients with end-stage renal disease and heart failure. The aim ...