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Efficient liver gene transfer with foamy virus vectors
(2013)
Liver gene transfer offers hope for the correction of genetic and acquired disorders. Efficient gene transfer in large animals can be obtained with hydrodynamic gene transfer (HGT), a method that can achieve sufficient ...
Seven new loci associated with age-related macular degeneration
(2013)
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association ...
A short survey on genetic sequences, chou's pseudo amino acid composition and its combination with fuzzy set theory
(2013)
The study of genetic sequences is of great importance in biology and medicine. Sequence analysis and taxonomy are two major fields of application of bioinformatics. In this survey, we present results concerning genetic ...
Mutations conferring colistin resistance development in Acinetobacter baumannii clinical isolates
(2013)
The colistin resistance mechanisms in Acinetobacter baumannii are largely unknown. In the present study, we investigated the characteristics and the mechanisms of colistin resistance in two genetically indistinguishable ...
Generalization of Youden index for multiple-class classification problems applied to the assessment of externally validated cognition in Parkinson disease screening
(2013)
Routine cognitive screening in Parkinson disease (PD) has become essential for management, to track progression and to assess clinical status in therapeutic trials. Patients with mild cognitive impairment (PD-MCI) are more ...