Πλοήγηση ανά Θέμα "splicing factor U2AF"

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Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

Fragkouli A., Koukouraki P., Vlachos I.S., Paraskevopoulou M.D., Hatzigeorgiou A.G., Doxakis E. (2017)

Aβ peptide that accumulates in Alzheimer's disease brain, derives from proteolytic processing of the amyloid precursor protein (APP) that exists in three main isoforms derived by alternative splicing. The isoform APP695, ...