Browsing by Subject "rheumatoid arthritis"

An 11- to 15-year clinical outcome study of the Advance Medial Pivot total knee arthroplasty: Pivot knee arthroplasty

Karachalios Th., Varitimidis S., Bargiotas K., Hantes M., Roidis N., Malizos K.N. (2016)

Aims The Advance Medial-Pivot total knee arthroplasty (TKA) was designed to reflect contemporary data regarding the kinematics of the knee. We wished to examine the longterm results obtained with this prosthesis by extending ...

2020 international consensus on ANCA testing beyond systemic vasculitis

Moiseev S., Cohen Tervaert J.W., Arimura Y., Bogdanos D.P., Csernok E., Damoiseaux J., Ferrante M., Flores-Suárez L.F., Fritzler M.J., Invernizzi P., Jayne D., Jennette J.C., Little M.A., McAdoo S.P., Novikov P., Pusey C.D., Radice A., Salama A.D., Savige J.A., Segelmark M., Shoenfeld Y., Sinico R.A., Sousa M.-J., Specks U., Terrier B., Tzioufas A.G., Vermeire S., Zhao M.-H., Bossuyt X. (2020)

This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ...

2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis

Nikiphorou E., Santos E.J.F., Marques A., Böhm P., Bijlsma J.W.J., Daien C.I., Esbensen B.A., Ferreira R.J.O., Fragoulis G.E., Holmes P., McBain H., Metsios G.S., Moe R.H., Stamm T.A., De Thurah A., Zabalan C., Carmona L., Bosworth A. (2021)

Background: An important but often insufficient aspect of care in people with inflammatory arthritis (IA) is empowering patients to acquire a good understanding of their disease and building their ability to deal effectively ...

Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis

Mavragani, C. P.; Yiannakouris, N.; Zintzaras, E.; Melistas, L.; Ritis, K.; Skopouli, F. N. (2007)

Objective. To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the 5'-flanking region and the ...

The angiogenic pathway 'vascular endothelial growth factor/flk-I (KDR)-receptor' in rheumatoid arthritis and osteoarthritis

Giatromanolaki, A.; Sivridis, E.; Atanassou, N.; Zois, E.; Thorpe, P. E.; Brekken, R. A.; Gatter, K. C.; Harris, A. L.; Koukourakis, I. M.; Koukourakis, M. I. (2001)

Active angiogenesis, together with an up-regulation of angiogenic factors, is evident in the synovium of both rheumatoid arthritis (RA) and osteoarthritis (OA). The present study assessed, by immunohistochemistry, the ...

Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis

Liaskos C., Rentouli S., Simopoulou T., Gkoutzourelas A., Norman G.L., Brotis A., Alexiou I., Katsiari C., Bogdanos D.P., Sakkas L.I. (2019)

Background: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE), but their presence in other rheumatic diseases has not been adequately investigated. Objectives: We aimed to assess ...

Anti-cd20 agents for multiple sclerosis: Spotlight on ocrelizumab and ofatumumab

Florou D., Katsara M., Feehan J., Dardiotis E., Apostolopoulos V. (2020)

Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a T-cell-mediated disorder. However, newer evidence shows that B ...

Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis

Alexiou, I.; Germenis, A.; Koutroumpas, A.; Kontogianni, A.; Theodoridou, K.; Sakkas, L. I. (2008)

The objective of our study was to establish whether there is an association between rheumatoid arthritis with extra-articular manifestations (exRA) and anti-cyclic citrullinated peptide 2 (anti-CCP2) antibodies in Greeks. ...

Anti-MCV antibodies predict radiographic progression in Greek patients with very early (<3 months duration) rheumatoid arthritis

Barouta G., Katsiari C.G., Alexiou I., Liaskos C., Varna A., Bogdanos D.P., Germenis A.E., Sakkas L.I. (2017)

This study aimed to assess the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) antibodies in very early rheumatoid arthritis (VERA) and in established rheumatoid arthritis (RA). Seventy-one ...

Association of anti-CCP positivity and carriage of TNFRII susceptibility variant with anti-TNF-α response in rheumatoid arthritis

Vasilopoulos, Y.; Bagiatis, V.; Stamatopoulou, D.; Zisopoulos, D.; Alexiou, I.; Sarafidou, T.; Settas, L.; Sakkas, L.; Mamuris, Z. (2011)

Objective: To investigate the possible influence of tumour necrosis factoralpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody ...

Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis

Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)

OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...

The autoimmunity–oral microbiome connection

Nikitakis N.G., Papaioannou W., Sakkas L.I., Kousvelari E. (2017)

To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the ...

Autonomous motivation to reduce sedentary behaviour is associated with less sedentary time and improved health outcomes in rheumatoid arthritis: a longitudinal study

O’Brien C.M., Duda J.L., Kitas G.D., Veldhuijzen van Zanten J.J.C.S., Metsios G.S., Fenton S.A.M. (2022)

Background: This longitudinal study investigated whether changes in autonomous and controlled motivation to reduce sedentary behaviour were associated with variability in sedentary, standing and stepping time and, in turn, ...

Bilateral Pleural Effusion in Rheumatoid Arthritis: Think Beyond the Obvious

Dimeas I.E., Sinis S.I., Dimeas G.E., Daniil Z. (2022)

An 86-year-old woman, non-smoker, with a medical history of rheumatoid arthritis for 20 years (stable at 5mg of prednisolone) was referred from a peripheral hospital to the Department of Respiratory Medicine of our tertiary ...

Breg Cells Are Numerically Decreased and Functionally Impaired in Patients with Systemic Sclerosis

Mavropoulos A., Simopoulou T., Varna A., Liaskos C., Katsiari C.G., Bogdanos D.P., Sakkas L.I. (2016)

Objective Breg cells, a regulatory cell subset that produces interleukin-10 (IL-10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number ...

Bursitis of the coccyx in an adult with rheumatoid arthritis mimicking a sacrococcygeal meningocele

Tzerefos C., Koukoulis G.K., Vlychou M., Brotis A.G., Fountas K.N., Paterakis K.N. (2021)

Background: Bursitis is a chronic inflammatory condition characterized by the deposition of cholesterol, macrophage infiltration, and bursal wall calcification. Bursitis is, however, rarely found in the sacrococcygeal ...

Cardiorespiratory fitness and physical activity in people who have rheumatoid arthritis at an increased risk of cardiovascular disease: a cross-sectional study

Sobejana M., van den Hoek J., Metsios G.S., Kitas G.D., Jorstad H.T., van der Leeden M., Pijnappels M., Lems W.F., Nurmohamed M.T., van der Esch M. (2021)

Lower cardiorespiratory fitness (CRF) and physical activity (PA) associate with higher cardiovascular disease (CVD) risk, but the relationship between CRF and PA in people who have rheumatoid arthritis (RA) at an increased ...

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

Nijs J., George S.Z., Clauw D.J., Fernández-de-las-Peñas C., Kosek E., Ickmans K., Fernández-Carnero J., Polli A., Kapreli E., Huysmans E., Cuesta-Vargas A.I., Mani R., Lundberg M., Leysen L., Rice D., Sterling M., Curatolo M. (2021)

Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms ...

Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: A multicenter, case-control study

Panopoulos S., Thomas K., Georgiopoulos G., Boumpas D., Katsiari C., Bertsias G., Drosos A.A., Boki K., Dimitroulas T., Garyfallos A., Papagoras C., Katsimbri P., Tziortziotis A., Adamichou C., Kaltsonoudis E., Argyriou E., Vosvotekas G., Sfikakis P.P., Vassilopoulos D., Tektonidou M.G. (2021)

Objectives: Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA. ...

Curcumin for the management of periodontitis and early ACPA-positive rheumatoid arthritis: Killing two birds with one stone

Asteriou E., Gkoutzourelas A., Mavropoulos A., Katsiari C., Sakkas L.I., Bogdanos D.P. (2018)

We propose curcumin as a preventive measure to avoid/manage periodontitis (PD), and as a natural immunosuppressant for rheumatoid arthritis (RA). PD, mainly caused by Porphyromonas gingivalis forming biofilm and leading ...