Πλοήγηση ανά Θέμα "neuroprotection"
Αποτελέσματα 1-18 από 18
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Anti-apoptotic and antioxidant activities of the mitochondrial estrogen receptor beta in n2a neuroblastoma cells
(2021)Estrogens are steroid hormones that play a crucial role in the regulation of the reproductive and non-reproductive system physiology. Among non-reproductive systems, the nervous system is mainly affected by estrogens due ... -
Chemical Characterisation-Biological Evaluation of Greek Cultivar Cardoon Seeds (Cynara cardunculus)A By-product with Potential High Added Value
(2021)Cynara cardunculus (artichoke) is a perennial plant of the Mediterranean basin, known since antiquity as food and for its therapeutic properties. Cynara is a relatively small genus with two cultivated species and one wild ... -
Clinically reliable cognitive decline in relapsing remitting multiple sclerosis: Is it the tip of the iceberg?
(2020)Objectives: Cognitive impairment is common in multiple sclerosis, but the brain MRI correlates in relapsing remitting multiple sclerosis remain controversial. The current study aimed to investigate whether cognitive decline ... -
Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
(2018)Aim: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. Patients & methods: This retrospective study included 65 patients (34 male, 52.3%) ... -
Effect of anoxia and hypoglycaemia on the expression of neuronal cell markers in the rat retina and hippocampus: Development of a rat ex vivo ischemia model
(2007)Neuronal ischemia leads to neuronal cells death due to glucose and oxygen deprivation. The goal of this study was the development of a rat ex vivo ischemia model for the deferential identification of anoxic and hypoglycaemic ... -
Effect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-aspartate and [3H]-GABA from rat retina and hippocampus
(2008)The modulation of the enhanced release of [3H]-D-Aspartate and [3H]GABA following ischemia-like conditions was studied in rat retinal and hippocampal preparations using a superfusion system. Ischemia was simulated by a ... -
Neurodegeneration and inflammation—an interesting interplay in parkinson’s disease
(2020)Parkinson’s disease (PD) is a neurodegenerative disorder, caused by, so far, unknown pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated mechanisms are pivotal to the pathogenicity and progression ... -
A neuroprotective bovine colostrum attenuates apoptosis in dexamethasone‐treated mc3t3‐e1 osteoblastic cells
(2021)Glucocorticoid‐induced osteoporosis (GIO) is one of the most common secondary forms of osteoporosis. GIO is partially due to the apoptosis of osteoblasts and osteocytes. In addition, high doses of dexamethasone (DEX), a ... -
Perioperative Use of Erythromycin Reduces Cognitive Decline after Coronary Artery Bypass Grafting Surgery: A Pilot Study
(2017)Objectives Adverse neurologic outcome can be a debilitating complication after cardiac surgery. The aim of this study was to investigate the potential neuroprotective action of erythromycin, a well known antibiotic agent, ... -
Personalized physiology-guided resuscitation in highly monitored patients with cardiac arrest—the PERSEUS resuscitation protocol
(2019)Resuscitation guidelines remain uniform across all cardiac arrest patients, focusing on the delivery of chest compressions to a standardized rate and depth and algorithmic vasopressor dosing. However, individualizing ... -
Postoperative cognitive disorders: An update
(2018)Background: Cognitive dysfunction is a common complication after surgery. It is a major cause for increased, sometimes long-term, morbidity and mortality. Methods: In this narrative review we performed a literature search ... -
Potential applications of optical coherence tomography angiography in glaucoma
(2018)Purpose of review: Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging modality that allows assessment of the retinal and choroidal vasculature. The scope of this review is to summarize recent ... -
The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
(2014)The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the ... -
Real-World Setting Comparison of Nonvitamin-K Antagonist Oral Anticoagulants Versus Vitamin-K Antagonists for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis
(2017)Background and Purpose - Evidence from the real-world setting complements evidence coming from randomized controlled trials. We aimed to summarize all available evidence from high-quality real-world observational studies ... -
The role of nitric oxide donors in schizophrenia: Basic studies and clinical applications
(2015)Schizophrenia is a complex and chronic mental health disease that affects nearly 1% of the population worldwide. While the current antipsychotic medications have profoundly impacted the treatment of schizophrenia over the ... -
The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation
(2022)Background: Valerenic acid (VA), a sesquiterpenoid of the plant Valeriana officinalis, has attracted attention of the research community due to its potential positive role against neurodegenerative diseases induced by ... -
Traumatic brain injury and gene knockout animal models: An up-to-date review
(2017)Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Identification of endogenous neuroprotective mechanisms after TBI and the development of therapeutic targets to improve TBI outcomes are ... -
Vegetable organosulfur compounds and their health promoting effects
(2017)Background: Trends in modern pharmaceutical science show an increase in demand for new drugs and diet supplements derived from natural products, while during the last decades, great research is conducted regarding the ...