Browsing by Subject "middle aged"

99mTc sestamibi as a prognostic factor of response to first-line therapy and outcome in patients with malignant lymphoma

Spyridonidis, T. J.; Matsouka, P.; Symeonidis, A.; Savvopoulos, C.; Vassilakos, P. J.; Apostolopoulos, D. J. (2013)

INTRODUCTION: Resistance to chemotherapy poses a major problem in cancer patients. Although of multifactorial origin, some of the implicated mechanisms also interfere with Tc-MIBI uptake and retention in cancer cells. The ...

Alpha-synuclein repeat variants and survival in parkinson's disease

Chung, S. J.; Biernacka, J. M.; Armasu, S. M.; Anderson, K.; Frigerio, R.; Aasly, J. O.; Annesi, G.; Bentivoglio, A. R.; Brighina, L.; Chartier-Harlin, M. C.; Goldwurm, S.; Hadjigeorgiou, G.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Krüger, R.; Lesage, S.; Markopoulou, K.; Mellick, G.; Morrison, K. E.; Puschmann, A.; Tan, E. K.; Crosiers, D.; Theuns, J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z. K.; Elbaz, A.; Maraganore, D. M.; Yahalom, G.; Orlev, Y.; Cohen, O. S.; Kozlova, E.; Friedman, E.; Inzelberg, R.; Hassin-Baer, S. (2014)

Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease ...

An anatomical update on the morphologic variations of S1 and S2

Karachalios, T.; Zibis, A. H.; Zintzaras, E.; Bargiotas, K.; Karantanas, A. H.; Malizos, K. N. (2010)

Although percutaneous fixation with iliosacral screws has been shown to be a safe and reproducible method for sacroiliac dislocation and sacral fractures, it is a technically demanding technique, and one of its contraindications ...

The antiphospholipid syndrome and infection

Dalekos, G. N.; Zachou, K.; Liaskos, C. (2001)

Infectious agents have been implicated in the induction of antiphospholipid (aPL) antibodies and the development of the antiphospholipid syndrome (APS). This review focuses on the types of aPL antibodies detected in ...

Association of anti-CCP positivity and carriage of TNFRII susceptibility variant with anti-TNF-α response in rheumatoid arthritis

Vasilopoulos, Y.; Bagiatis, V.; Stamatopoulou, D.; Zisopoulos, D.; Alexiou, I.; Sarafidou, T.; Settas, L.; Sakkas, L.; Mamuris, Z. (2011)

Objective: To investigate the possible influence of tumour necrosis factoralpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody ...

Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis

Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)

OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...

Blocking of interleukin-10 receptor - A novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus

Rigopoulou, E. I.; Abbott, W. G. H.; Haigh, P.; Naoumov, N. V. (2005)

Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity and enhanced interleukin-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade ...

Bloodstream infections and sepsis in Greece: Over-time change of epidemiology and impact of de-escalation on final outcome

Koupetori, M.; Retsas, T.; Antonakos, N.; Vlachogiannis, G.; Perdios, I.; Nathanail, C.; Makaritsis, K.; Papadopoulos, A.; Sinapidis, D.; Giamarellos-Bourboulis, E. J.; Pneumatikos, I.; Gogos, C.; Armaganidis, A.; Paramythiotou, E. (2014)

Background: Choice of empirically prescribed antimicrobials for sepsis management depends on epidemiological factors. The epidemiology of sepsis in Greece was studied in two large-periods.Methods: Sepsis due to bloodstream ...

Cell migration leads to spatially distinct but clonally related airway cancer precursors

Pipinikas, C. P.; Kiropoulos, T. S.; Teixeira, V. H.; Brown, J. M.; Varanou, A.; Falzon, M.; Capitanio, A.; Bottoms, S. E.; Carrol, B.; Navani, N.; McCaughan, F.; George, J. P.; Giangreco, A.; Wright, N. A.; McDonald, S. A. C.; Graham, T. A.; Janes, S. M. (2014)

Background Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing ...

Characteristics of Farm Injuries in Greece

Alexe, D. M.; Petridou, E.; Dessypris, N.; Skenderis, N.; Trichopoulos, D. (2003)

Methodology: During a five-year period (1996-2000), 4,326 unintentional farm injuries have been recorded by the Emergency Department Injury Surveillance System in Greece. Data concerning demographic variables, accident ...

Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis

Sakkas, L. I.; Koussidis, G.; Avgerinos, E.; Gaughan, J.; Platsoucas, C. D. (2004)

Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain patients, OA is an inflammatory disease and that patients often ...

High resolution computed tomography findings on the lung of early breast-cancer patients treated by postoperative breast irradiation with a hypofractionated radiotherapy schedule

Plataniotis, G. A.; Theofanopoulou, M. E.; Sotiriadou, K.; Vlychou, M.; Fountoulis, G. A.; Fezoulidis, J. (2005)

BACKGROUND: Hypofractionated breast radiotherapy (RT), although convenient for patients and health care systems, could have a negative impact on normal tissues such as lung. AIM: To evaluate radiation-induced lung toxicity ...

Identifying organizational culture and subcultures within Greek public hospitals

Bellou, V. (2008)

Purpose - Since organizational culture is undoubtedly critical in a highly competitive era, the purpose of this paper is to identify the core culture dimensions that exist within Greek public hospitals and examine inherent ...

Immunoglobulin D myeloma: Clinical features and outcome in the era of novel agents

Zagouri, F.; Kastritis, E.; Symeonidis, A. S.; Giannakoulas, N.; Katodritou, E.; Delimpasi, S.; Repousis, P.; Terpos, E.; Dimopoulos, M. A. (2014)

Objectives: Immunoglobulin D (IgD) multiple myeloma is an uncommon variant of the disease probably associated with poorer prognosis. However, data on IgD myeloma patients treated in the novel agent era are lacking. Methods: ...

Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer

Karanikas, V.; Zamanakou, M.; Kerenidi, T.; Dahabreh, J.; Hevas, A.; Nakou, M.; Gourgoulianis, K. I.; Germenis, A. E. (2007)

Background: The expression of indoleamine 2,3-dioxygenase (IDO) by tumor cells has been considered as a major tumor immune escape mechanism. The aim of this study was to investigate the expression of IDO in lung cancer ...

The influence of the acromioclavicular joint degeneration on supraspinatus outlet impingement and the acromion shape

Roidis, N. T.; Motamed, S.; Vaishnav, S.; Ebramzadeh, E.; Karachalios, T. S.; Itamura, J. M. (2009)

PURPOSE: To assess the anatomic association of acromioclavicular joint degeneration to supraspinatus outlet impingement and the acromion shape. METHODS: Sagittal oblique magnetic resonance images of 49 shoulders in 49 ...

Long-term prognostic value of Tc-99m tetrofosmin myocardial gated-SPECT imaging in asymptomatic patients after percutaneous coronary intervention

Georgoulias, P.; Demakopoulos, N.; Tzavara, C.; Giannakou, S.; Valotassiou, V.; Tsougos, I.; Xaplanteris, P.; Fezoulidis, I. (2008)

PURPOSE: To evaluate the long-term prognostic value of Tc-99m tetrofosmin myocardial gated-SPECT in asymptomatic patients after coronary artery stenting. MATERIALS AND METHODS: We included 246 consecutive patients in the ...

Miliary tuberculosis with no pulmonary involvement in myelodysplastic syndromes: A curable, yet rarely diagnosed, disease: Case report and review of the literature

Neonakis, I. K.; Alexandrakis, M. G.; Gitti, Z.; Tsirakis, G.; Krambovitis, E.; Spandidos, D. A. (2008)

Background: Although tuberculosis is not uncommon among patients with myelodysplastic syndrome (MDS), only a few reports of such patients suffering from miliary tuberculosis (MT) exist. MT often presents as a fever of ...

Multiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus-infected patients is associated with the possession of HLA B51

Bogdanos, D. P.; Lenzi, M.; Okamoto, M.; Rigopoulou, E. I.; Muratori, P.; Ma, Y.; Muratori, L.; Tsantoulas, D.; Mieli-Vergani, G.; Bianchi, F. B.; Vergani, D. (2004)

Liver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected ...

Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease

Li, Y.; Rowland, C.; Xiromerisiou, G.; Lagier, R. J.; Schrodi, S. J.; Dradiotis, E.; Ross, D.; Bui, N.; Catanese, J.; Aggelakis, K.; Grupe, A.; Hadjigeorgiou, G. (2008)

Susceptibility to sporadic Parkinson's diseases (PD) is thought to be influence by both genetic and environmental factors and thier interaction with each other. Statistical models including multiples variants in axon ...