Browsing by Subject "major clinical study"

Acute phase markers for the differentiation of infectious and malignant pleural effusions

Kiropoulos, T. S.; Kostikas, K.; Oikonomidi, S.; Tsilioni, I.; Nikoulis, D.; Germenis, A.; Gourgoulianis, K. I. (2007)

Acute-phase markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), have been studied in inflammatory and malignant disorders. We examined the diagnostic value of these ...

Aiming at Tobacco Harm Reduction: A survey comparing smokers differing in readiness to quit

Loumakou, M.; Brouskeli, V.; Sarafidou, J. O. (2006)

Background: Greece has the highest smoking rates (in the 15-nation bloc) in Europe. The purpose of this study was to investigate Greek smokers' intention and appraisal of capability to quit employing the theoretical ...

An anatomical update on the morphologic variations of S1 and S2

Karachalios, T.; Zibis, A. H.; Zintzaras, E.; Bargiotas, K.; Karantanas, A. H.; Malizos, K. N. (2010)

Although percutaneous fixation with iliosacral screws has been shown to be a safe and reproducible method for sacroiliac dislocation and sacral fractures, it is a technically demanding technique, and one of its contraindications ...

Ancestry of the Timorese: Age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world

Morrison, M. A.; Magalhaes, T. R.; Ramke, J.; Smith, S. E.; Ennis, S.; Simpson, C. L.; Portas, L.; Murgia, F.; Ahn, J.; Dardenne, C.; Mayne, K.; Robinson, R.; Morgan, D. J.; Brian, G.; Lee, L.; Woo, S. J.; Zacharaki, F.; Tsironi, E. E.; Miller, J. W.; Kim, I. K.; Park, K. H.; Bailey-Wilson, J. E.; Farrer, L. A.; Stambolian, D.; DeAngelis, M. M. (2015)

We observed that the third leading cause of blindness in the world, age-related macular degeneration (AMD), occurs at a very low documented frequency in a population-based cohort from Timor-Leste. Thus, we determined a ...

Association of anti-CCP positivity and carriage of TNFRII susceptibility variant with anti-TNF-α response in rheumatoid arthritis

Vasilopoulos, Y.; Bagiatis, V.; Stamatopoulou, D.; Zisopoulos, D.; Alexiou, I.; Sarafidou, T.; Settas, L.; Sakkas, L.; Mamuris, Z. (2011)

Objective: To investigate the possible influence of tumour necrosis factoralpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody ...

Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis

Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)

OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...

Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives

Diamantopoulos, E. J.; Andreadis, E. A.; Vassilopoulos, C. V.; Vlachonikolis, I. G.; Tarassi, K. E.; Chatzis, N. A.; Giannakopoulos, N. S.; Papasteriades, C. A. (2001)

The aim of this study was to investigate the hypothesis that the expression of certain HLA antigens may constitute a risk marker for cardiovascular hypertrophy in subjects with arterial hypertension. We examined 158 subjects ...

Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: A case-control study

Qin, J.; Shi, D.; Dai, J.; Zhu, L.; Tsezou, A.; Jiang, Q. (2010)

Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) ...

Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset

Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)

The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...

ASTRAL-R score predicts non-recanalisation after intravenous thrombolysis in acute ischaemic stroke

Vanacker, P.; Heldner, M. R.; Seiffge, D.; Mueller, H.; Eskandari, A.; Traenka, C.; Ntaios, G.; Mosimann, P. J.; Sztajzel, R.; Pereira, V. M.; Cras, P.; Engelter, S.; Lyrer, P.; Fischer, U.; Lambrou, D.; Arnold, M.; Michel, P. (2015)

Intravenous thrombolysis (IVT) as treatment in acute ischaemic strokes may be insufficient to achieve recanalisation in certain patients. Predicting probability of non-recanalisation after IVT may have the potential to ...

Autoantibodies in patients with systemic sclerosis and cancer: A case-control study

Derk, C. T.; Sakkas, L. I.; Rasheed, M.; Artlett, C.; Jimenez, S. A. (2003)

Objective. To determine the prevalence of specific autoantibodies in a cohort of patients with systemic sclerosis (SSc) and a diagnosis of cancer, and to compare it to that in a group of patients with SSc who were never ...

Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases

Villalta, D.; Mytilinaiou, M. G.; Elsner, M.; Hentschel, C.; Cuccato, J.; Somma, V.; Schierack, P.; Roggenbuck, D.; Bogdanos, D. P. (2015)

Background: The liver asialoglycoprotein receptor (ASGPR) is the only organ-specific autoantigenic target in autoimmune hepatitis (AIH) patients and corresponding autoantibodies (Abs) have been suggested aiding in the ...

Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis

Rigopoulou, E. I.; Mytilinaiou, M.; Romanidou, O.; Liaskos, C.; Dalekos, G. N. (2007)

Background. Non-organ specific autoantibodies are highly prevalent in patients with chronic hepatitis C (HCV). Among them, anti-liver kidney microsomal type 1 (LKM1) antibody - the serological marker of type 2 autoimmune ...

Bayley-III scales at 12 months of corrected age in preterm infants: Patterns of developmental performance and correlations to environmental and biological influences

Velikos, K.; Soubasi, V.; Michalettou, I.; Sarafidis, K.; Nakas, C.; Papadopoulou, V.; Zafeiriou, D.; Drossou, V. (2015)

Background and aims: Premature infants are at high risk for neurodevelopmental impairment (NDI) even in the absence of known brain complications of prematurity. Evaluation of the effectiveness of therapeutic interventions ...

Bloodstream infections and sepsis in Greece: Over-time change of epidemiology and impact of de-escalation on final outcome

Koupetori, M.; Retsas, T.; Antonakos, N.; Vlachogiannis, G.; Perdios, I.; Nathanail, C.; Makaritsis, K.; Papadopoulos, A.; Sinapidis, D.; Giamarellos-Bourboulis, E. J.; Pneumatikos, I.; Gogos, C.; Armaganidis, A.; Paramythiotou, E. (2014)

Background: Choice of empirically prescribed antimicrobials for sepsis management depends on epidemiological factors. The epidemiology of sepsis in Greece was studied in two large-periods.Methods: Sepsis due to bloodstream ...

Breast cancer status in Greece: 35-Years experience [1]

Tsakraklides, V.; Apostolikas, N.; Gourgoulianis, K.; Agnantis, N. (2002)

Clinical phenotype in patients with α-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease

Papapetropoulos, S.; Paschalis, C.; Athanassiadou, A.; Papadimitriou, A.; Ellul, J.; Polymeropoulos, M. H.; Papapetropoulos, Th (2001)

Objective - An Ala53Thr mutation of the α-synuclein gene has been recently identified as a rare cause of autosomal Parkinson's disease (PD). The clinical characteristics of 15 patients with PD living in Greece with the ...

Clinical significance of organ- and non-organ-specific autoantibodies on the response to anti-viral treatment of patients with chronic hepatitis C

Gatselis, N. K.; Georgiadou, S. P.; Koukoulis, G. K.; Tassopoulos, N.; Zachou, K.; Liaskos, C.; Hatzakis, A.; Dalekos, G. N. (2006)

Background: Development of organ- and non-organ-specific autoantibodies has been reported in hepatitis C virus patients treated with interferon-α plus/minus ribavirin. Aims: To address whether prevalence and the titre of ...

Construct validity of the test of gross motor development: A cross-validation approach

Evaggelinou, C.; Tsigilis, N.; Papa, A. (2002)

This study was designed to examine the underlying structure of the Test of Gross Motor Development (TGMD) in Ulrich (1985). The TGMD was administered to 644 children who were randomly divided into two groups (calibration ...

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach

Silveira, A. C.; Morrison, M. A.; Ji, F.; Xu, H.; Reinecke, J. B.; Adams, S. M.; Arneberg, T. M.; Janssian, M.; Lee, J. E.; Yuan, Y.; Schaumberg, D. A.; Kotoula, M. G.; Tsironi, E. E.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Miller, J. W.; Kim, I. K.; Hageman, G. S.; Farrer, L. A.; Haider, N. B.; DeAngelis, M. M. (2010)

To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ...