Browsing by Subject "lactate dehydrogenase"

99mTc sestamibi as a prognostic factor of response to first-line therapy and outcome in patients with malignant lymphoma

Spyridonidis, T. J.; Matsouka, P.; Symeonidis, A.; Savvopoulos, C.; Vassilakos, P. J.; Apostolopoulos, D. J. (2013)

INTRODUCTION: Resistance to chemotherapy poses a major problem in cancer patients. Although of multifactorial origin, some of the implicated mechanisms also interfere with Tc-MIBI uptake and retention in cancer cells. The ...

Clinical immunology quiz - Case 1

Speletas, M.; Kalala, F.; Dalekos, G. (2007)

Comparison between leg and arm eccentric exercises of the same relative intensity on indices of muscle damage

Jamurtas, A. Z.; Theocharis, V.; Tofas, T.; Tsiokanos, A.; Yfanti, C.; Paschalis, V.; Koutedakis, Y.; Nosaka, K. (2005)

Many exercise models have demonstrated associations between eccentric muscle actions and muscle damage. However, the magnitude of muscle damage varies among the models. It appears that responses to eccentric exercise are ...

Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy?

Gerogianni, I.; Papala, M.; Tsopa, P.; Zigoulis, P.; Dimoulis, A.; Kostikas, K.; Kiropoulos, T.; Gourgoulianis, K. I. (2008)

Could IFN-γ predict the development of residual pleural thickening tuberculous pleurisy? I. Gerogianni, M. Papala, P. Tsopa, P. Zigoulis, A. Dimoulis, K. Kostikas, T. Kiropoulos, KI Gourgoulianis. Background. The aim of ...

Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Antoniadis, N.; Liakopoulos, V.; Stefanidis, I. (2013)

Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ...

Immunoglobulin D myeloma: Clinical features and outcome in the era of novel agents

Zagouri, F.; Kastritis, E.; Symeonidis, A. S.; Giannakoulas, N.; Katodritou, E.; Delimpasi, S.; Repousis, P.; Terpos, E.; Dimopoulos, M. A. (2014)

Objectives: Immunoglobulin D (IgD) multiple myeloma is an uncommon variant of the disease probably associated with poorer prognosis. However, data on IgD myeloma patients treated in the novel agent era are lacking. Methods: ...

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells

Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)

Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells. One mechanism is through the inhibition of aerobic glycolysis. Another prerequisite for T-cell ...

Intense basketball-simulated exercise induces muscle damage in men with elevated anterior compartment pressure

Kostopoulos, N.; Fatouros, I. G.; Siatitsas, I.; Baltopoulos, P.; Kambas, A.; Jamurtas, A. Z.; Fotinakis, P. (2004)

The purpose of the present investigation was to examine the levels of muscle soreness, muscle damage, and performance output in men with (S, n = 24) or without (A, n = 24) chronic compartment syndrome (CACS)-related symptoms ...

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells

Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)

Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the ...