Browsing by Subject "immunohistochemistry"

An Activating Janus kinase-3 mutation is associated with cytotoxic T lymphocyte antigen-4-dependent Immune dysregulation syndrome

Sic H., Speletas M., Cornacchione V., Seidl M., Beibel M., Linghu B., Yang F., Sevdali E., Germenis A.E., Oakeley E.J., Vangrevelinghe E., Sailer A.W., Traggiai E., Gram H., Eibel H. (2017)

Heterozygous mutations in the cytotoxic T lymphocyte antigen-4 (CTLA-4) are associated with lymphadenopathy, autoimmunity, immune dysregulation, and hypogammaglobulinemia in about 70% of the carriers. So far, the incomplete ...

Acute in vivo exposure to fentanyl reduces GABA immunoreactivity in the CA1 area of the rat hippocampus

Kouvaras, E.; Kilindris, T.; Vasilaki, A.; Asprodini, E. K. (2008)

The effect of in vivo fentanyl treatment on GABAergic immunoreactivity was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4x80 μg/kg, s.c./15min). GABA immunohistochemistry ...

Alanyl-glutamine restores tight junction organization after disruption by a conventional peritoneal dialysis fluid

Bartosova M., Herzog R., Ridinger D., Levai E., Jenei H., Zhang C., González Mateo G.T., Marinovic I., Hackert T., Bestvater F., Hausmann M., Cabrera M.L., Kratochwill K., Zarogiannis S.G., Schmitt C.P. (2020)

Understanding and targeting the molecular basis of peritoneal solute and protein transport is essential to improve peritoneal dialysis (PD) efficacy and patient outcome. Supplementation of PD fluids (PDF) with alanyl-glutamine ...

Aldehyde dehydrogenase 1B1: Molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

Stagos, D.; Chen, Y.; Brocker, C.; Donald, E.; Jackson, B. C.; Orlicky, D. J.; Thompson, D. C.; Vasiliou, V. (2010)

Ethanol-induced damage is largely attributed to its toxic metabolite, acetaldehyde. Clearance of acetaldehyde is achieved by its oxidation, primarily catalyzed by the mitochondrial class II aldehyde dehydrogenase (ALDH2). ...

Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis

Zachou K., Arvaniti P., Lyberopoulou A., Sevdali E., Speletas M., Ioannou M., Koukoulis G.K., Renaudineau Y., Dalekos G.N. (2022)

Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ...

Anterior and Posterior Cruciate Ligaments Mechanoreceptors: A Review of Basic Science

Banios K., Raoulis V., Fyllos A., Chytas D., Mitrousias V., Zibis A. (2022)

Proprioception is a specialized sensory modality encompassing the movement of the joint and its position in space, and it involves the conversion of mechanical deformation of tissues into neural signals. Mechanoreceptors ...

Apocrine and eccrine hidrocystomas: A clinicopathological study

Koumaki D., Papadakis M., Lagoudaki E., Manios G.A., Kassotakis D., Doxastaki A., Krasagakis K., Manios A. (2021)

Introduction: Eccrine and apocrine hidrocystomas are uncommon, benign, cystic proliferations of the sweat glands usually located on the head and neck area. Objectives: To describe the key clinical and histopathological ...

Arthritis and Myositis in a Patient Treated with Programmed Cell Death-1 (PD-1) Inhibitor Pembrolizumab for Lung Cancer

Pagkopoulou E., Simopoulou T., Maragkouli E., Perifanou-Sotiri S., Kotsakis A., Bogdanos D.P. (2020)

Immune checkpoint inhibitors (ICIs) are a new class of drug that have demonstrated efficacy across many cancer types. Because of their nature and mode of action, ICIs unleash immune activation raising concerns as to whether ...

Assessment of copper accumulation in archived liver specimens from cats

Yamkate P., Gold R.M., Xenoulis P.G., Steiger K., Twedt D.C., Suchodolski J.S., Steiner J.M., Lidbury J.A. (2021)

Objectives: The aim of this study was to assess hepatic copper concentrations and zonal distribution in cat liver specimens. Methods: For this study, 121 archived, formalin-fixed, paraffin-embedded liver specimens from ...

Association of Pathology Markers with Somatostatin Analogue Responsiveness in Acromegaly

Kontogeorgos G., Markussis V., Thodou E., Kyrodimou E., Choreftaki T., Nomikos P., Lampropoulos K.I., Tsagarakis S. (2022)

Background. Somatotroph adenomas (SAs) exhibit a variable responsiveness to somatostatin analogue (SS-a) treatment, a process that is not well understood. We investigated established and novel histological markers as ...

Bone marrow side population cells are enriched for progenitors capable of myogenic differentiation

Luth, E. S.; Jun, S. J.; Wessen, M. K.; Liadaki, K.; Gussoni, E.; Kunkel, L. M. (2008)

Although the contribution of bone marrow-derived cells to regenerating skeletal muscle has been repeatedly documented, there remains considerable debate as to whether this incorporation is exclusively a result of inflammatory ...

Cancer patient care during different war times; is the response too slow?

Tolia M., Kamposioras K., Symvoulakis E.K., Mauri D., Skouras P., Schizas D., Charalampakis N., Kokakis I., Matthaios D., Gazouli I., Ferentinos K., Girvalaki C., Apostolidis K. (2022)

[No abstract available]

A Case of Cervical Carcinoid and Review of the Literature

Papatsimpas G., Samaras I., Theodosiou P., Papacharalampous K., Maragkouli E., Papadopoulos N.V., Tsapakidis K., Litos I., Sogka E., Kostopoulou E., Koukoulis G.K. (2017)

Uterine cervix carcinoids are distinct neuroendocrine cervical tumors, representing a comparatively small percentage of them. These well-differentiated neoplasms are far less prevalent than small-and large-cell carcinomas, ...

CD8+ PD-1+ T-cells and PD-L1+ circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance?

Kotsakis A., Kallergi G., Aggouraki D., Lyristi Z., Koinis F., Lagoudaki E., Koutsopoulos A., Georgoulias V., Vetsika E.-K. (2019)

Background: Since tumor cells may escape from immune surveillance through the programmed cell death 1 (PD-1)/programmed death ligand (PD-L)1 axis, this study was designed in order to evaluate whether there is a correlation ...

Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions

Lakiotaki E., Giaginis C., Tolia M., Alexandrou P., Delladetsima I., Giannopoulou I., Kyrgias G., Patsouris E., Theocharis S. (2015)

The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids), and proteins responsible for their metabolism participate in many different functions indispensable ...

A comparison in concentration of heat shock proteins (HSP) 70 and 90 on chorionic villi of human placenta in normal pregnancies and in missed miscarriages

Sotiriou, S.; Liatsos, K.; Ladopoulos, I.; Arvanitis, D. L. (2004)

Purpose: To investigate the role of heat shock protein (HSP) on the chorionic villi of human placenta! cells and to compare the concentration of placental HSP70 & 90 in term deliveries and in missed miscarriages. Materials ...