Browsing by Subject "genomics"

Aedes aegypti lines for combined sterile insect technique and incompatible insect technique applications: the importance of host genomic background

Carvalho D.O., Torres-Monzon J.A., Koskinioti P., Dilrukshi Wijegunawardana N.D.A., Liang X., Pillwax G., Xi Z., Bourtzis K. (2020)

Aedes aegypti L. (Diptera: Culicidae), being the primary vector of pathogenic arboviruses, is a target for the development of novel genetic approaches to complement current conventional vector control strategies such as ...

Analysis of soil eDNA functional genes: potential to increase profitability and sustainability of pastoral agriculture

Wakelin S.A., Cave V.M., Dignam B.E., D’Ath C., Tourna M., Condron L.M., Zhou J., Van Nostrand J.D., O’Callaghan M. (2016)

Management of soil biological resources to optimise plant production, efficiency of nutrient inputs, and system sustainability is an emerging opportunity for pastoral agriculture. To achieve these goals, suitable tools ...

Comparative analysis of the core proteomes among the Pseudomonas major evolutionary groups reveals species-specific adaptations for Pseudomonas aeruginosa and Pseudomonas chlororaphis

Nikolaidis M., Mossialos D., Oliver S.G., Amoutzias G.D. (2020)

The Pseudomonas genus includes many species living in diverse environments and hosts. It is important to understand which are the major evolutionary groups and what are the genomic/proteomic components they have in common ...

Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine

Dedepsidis, E.; Karakasiliotis, I.; Paximadi, E.; Kyriakopoulou, Z.; Komiotis, D.; Markoulatos, P. (2006)

In the present study, a genomic analysis of full VP1 sequence region of 15 clinical re-isolates (14 healthy vaccinees and one bone marrow tumor patient) was conducted, aiming to the identification of mutations and to the ...

Discovery Strategies of bioactive compounds synthesized by nonribosomal peptide synthetases and type-I polyketide synthases derived from marine microbiomes

Amoutzias G.D., Chaliotis A., Mossialos D. (2016)

Considering that 70% of our planet's surface is covered by oceans, it is likely that undiscovered biodiversity is still enormous. A large portion of marine biodiversity consists of microbiomes. They are very attractive ...

Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach

Charitou T., Kontou P.I., Tamposis I.A., Pavlopoulos G.A., Braliou G.G., Bagos P.G. (2022)

Available drugs have been used as an urgent attempt through clinical trials to minimize severe cases of hospitalizations with Coronavirus disease (COVID-19), however, there are limited data on common pharmacogenomics ...

Editorial: Current Challenges in Cardioembolic Stroke

Fuentes B., Ntaios G., Putaala J. (2021)

[No abstract available]

From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression

Mentis A.-F.A., Dardiotis E., Katsouni E., Chrousos G.P. (2021)

The pervasive and frequently devastating nature of aggressive behavior calls for a collective effort to understand its psychosocial and neurobiological underpinnings. Regarding the latter, diverse brain areas, neural ...

Genomics of habitat choice and adaptive evolution in a deep-sea fish

Gaither M.R., Gkafas G.A., De Jong M., Sarigol F., Neat F., Regnier T., Moore D., Gröcke D.R., Hall N., Liu X., Kenny J., Lucaci A., Hughes M., Haldenby S., Hoelzel A.R. (2018)

Intraspecific diversity promotes evolutionary change, and when partitioned among geographic regions or habitats can form the basis for speciation. Marine species live in an environment that can provide as much scope for ...

Going retro: Oxidative stress biomarkers in modern redox biology

Margaritelis N.V., Cobley J.N., Paschalis V., Veskoukis A.S., Theodorou A.A., Kyparos A., Nikolaidis M.G. (2016)

The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers ...

GWAR: Robust analysis and meta-analysis of genome-wide association studies

Dimou N.L., Tsirigos K.D., Elofsson A., Bagos P.G. (2017)

Motivation: In the context of genome-wide association studies (GWAS), there is a variety of statistical techniques in order to conduct the analysis, but, in most cases, the underlying genetic model is usually unknown. Under ...

HOW CAN BIOINFORMATICS AND TOXICOGENOMICS ASSIST THE NEXT GENERATION OF RESEARCH ON PHYSICAL EXERCISE AND ATHLETIC PERFORMANCE

Kerksick, C. M.; Tsatsakis, A. M.; Hayes, A. W.; Kafantaris, I.; Kouretas, D. (2015)

The past 2-3 decades have seen an explosion in analytical areas related to "omic" technologies. These advancements have reached a point where their application can be and are being used as a part of exercise physiology and ...

Human mesenchymal stem cells with enhanced telomerase activity acquire resistance against oxidative stress-induced genomic damage

Trachana V., Petrakis S., Fotiadis Z., Siska E.K., Balis V., Gonos E.S., Kaloyianni M., Koliakos G. (2017)

Background Human mesenchymal stem cells (MSC) are important tools for several cell-based therapies. However, their use in such therapies requires in vitro expansion during which MSCs quickly reach replicative senescence. ...

Hypoxia-Inducible Factor-2-Altered Urothelial Carcinoma: Clinical and Genomic Features

Vlachostergios P.J., Tamposis I.A., Anagnostou M., Papathanassiou M., Mitrakas L., Zachos I., Thodou E., Samara M., Tzortzis V. (2022)

Background: Hypoxia is recognized as a key feature of cancer growth and is involved in various cellular processes, including proliferation, angiogenesis, and immune surveillance. Besides hypoxia-inducible factor 1-alpha ...

LaGomiCs - Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order

Fontanesi L., Di Palma F., Flicek P., Smith A.T., Thulin C.-G., Alves P.C., Abrantes J., Andersson L., Angelone C., Boonstra R., Campos R., Carneiro M., Casadio R., Cervantes F.A., Dahal N., Djan M., Esteves P.J., Etherington G., Fan J., Fickel J., Ge D., Husband T., King T., Kovach A.I., Lavazza A., Letty J., Lissovsky A.A., Mage R., Mamuris Z., Martelli P.L., McGreevy T., Jr., Melo-Ferreira J., Muffato M., Ramakrishnan U., Randi E., Reid N., Ribani A., Robinson T.J., Russello M.A., Schiavo G., Schneider-Gricar V., Solari K.A., Streeter I., Tizzani P., Tur A., Utzeri V.J., Velickovic N., Vernesi C., Yang Q., Lagomorph Genomics Consortium (2016)

The order Lagomorpha comprises about 90 living species, divided in 2 families: the pikas (Family Ochotonidae), and the rabbits, hares, and jackrabbits (Family Leporidae). Lagomorphs are important economically and scientifically ...

Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses

Nikolaidis M., Mimouli K., Kyriakopoulou Z., Tsimpidis M., Tsakogiannis D., Markoulatos P., Amoutzias G.D. (2019)

Recombination is a driving force for the emergence, evolution and virulence/epidemics of viruses, comprising the Enterovirus genus of the Picornaviridae family, important for human and animal health. By analyzing 2949 ...

Longitudinal Monitoring of Parkinson's Disease in Different Ethnic Cohorts: The DodoNA and LONG-PD Study

Markopoulou K., Aasly J., Chung S.J., Dardiotis E., Wirdefeldt K., Premkumar A.P., Schoneburg B., Kartha N., Wilk G., Wei J., Simon K.C., Tideman S., Epshteyn A., Hadsell B., Garduno L., Pham A., Frigerio R., Maraganore D. (2020)

Background: Different factors influence severity, progression, and outcomes in Parkinson's disease (PD). Lack of standardized clinical assessment limits comparison of outcomes and availability of well-characterized cohorts ...

Mitogenomic analysis in European brown hare (Lepus europaeus) proposes genetic and functional differentiation between the distinct lineages

Giannoulis T., Stamatis C., Tsipourlianos A., Mamuris Z. (2018)

European brown hare is a small game species spreading across Europe to Asia Minor, with important economic traits. Population genetics studies using mitochondrial DNA markers have revealed the existence of two major ...

Molecular diversity and phylogeny of indigenous Rhizobium leguminosarum strains associated with Trifolium repens plants in Romania

Efrose R.C., Rosu C.M., Stedel C., Stefan A., Sirbu C., Gorgan L.D., Labrou N.E., Flemetakis E. (2018)

The symbiotic nitrogen fixing legumes play an essential role in sustainable agriculture. White clover (Trifolium repens L.) is one of the most valuable perennial legumes in pastures and meadows of temperate regions. Despite ...

Multi-branch Convolutional Neural Network for Identification of Small Non-coding RNA genomic loci

Georgakilas G.K., Grioni A., Liakos K.G., Chalupova E., Plessas F.C., Alexiou P. (2020)

Genomic regions that encode small RNA genes exhibit characteristic patterns in their sequence, secondary structure, and evolutionary conservation. Convolutional Neural Networks are a family of algorithms that can classify ...