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Auflistung Nach Schlagwort "genome"

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    • Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez C., Kemp J.P., Dimou N.L., Kreiner E., Chesi A., Zemel B.S., Bønnelykke K., Boer C.G., Ahluwalia T.S., Bisgaard H., Evangelou E., Heppe D.H.M., Bonewald L.F., Gorski J.P., Ghanbari M., Demissie S., Duque G., Maurano M.T., Kiel D.P., Hsu Y.-H., Van Der Eerden B.C.J., Ackert-Bicknell C., Reppe S., Gautvik K.M., Raastad T., Karasik D., Van De Peppel J., Jaddoe V.W.V., Uitterlinden A.G., Tobias J.H., Grant S.F.A., Bagos P.G., Evans D.M., Rivadeneira F. (2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...

    • DIANA-miRGen v4: Indexing promoters and regulators for more than 1500 microRNAs 

      Perdikopanis N., Georgakilas G.K., Grigoriadis D., Pierros V., Kavakiotis I., Alexiou P., Hatzigeorgiou A. (2021)
      Deregulation of microRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor ...

    • DIANA-miTED: A microRNA tissue expression database 

      Kavakiotis I., Alexiou A., Tastsoglou S., Vlachos I.S., Hatzigeorgiou A.G. (2022)
      microRNAs (miRNAs) are short (∼23nt) single-stranded non-coding RNAs that act as potent post-transcriptional gene expression regulators. Information about miRNA expression and distribution across cell types and tissues is ...

    • Erratum: "The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species", [Genome Biol. (2016), 17, (192)] 

      Papanicolaou A., Schetelig M.F., Arensburger P., Atkinson P.W., Benoit J.B., Bourtzis K., Castañera P., Cavanaugh J.P., Chao H., Childers C., Curril I., Dinh H., Doddapaneni H.V., Dolan A., Dugan S., Friedrich M., Gasperi G., Geib S., Georgakilas G., Gibbs R.A., Giers S.D., Gomulski L.M., González-Guzmán M., Guillem-Amat A., Han Y., Hatzigeorgiou A.G., Hernández-Crespo P., Hughes D.S.T., Jones J.W., Karagkouni D., Koskinioti P., Lee S.L., Malacrida A.R., Manni M., Mathiopoulos K., Meccariello A., Munoz-Torres M., Murali S.C., Murphy T.D., Muzny D.M., Oberhofer G., Ortego F., Paraskevopoulou M.D., Poelchau M., Qu J., Reczko M., Robertson H.M., Rosendale A.J., Rosselot A.E., Saccone G., Salvemini M., Savini G., Schreiner P., Scolari F., Siciliano P., Sim S.B., Tsiamis G., Ureña E., S.Vlachos I., Werren J.H., Wimmer E.A., Worley K.C., Zacharopoulou A., Richards S., Handler A.M. (2017)
      After publication of our recent article [1] we noticed that Monica Munoz-Torres had been omitted from the author list. We have now added her, and the updated Funding and Authors' contributions sections are below. © The ...

    • A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database 

      Zintzaras, E.; Zdoukopoulos, N. (2009)
      In an electronic search of the literature, the authors systematically retrieved all published studies that investigated genetic susceptibility to peripheral arterial disease (PAD). They created a comprehensive database of ...

    • Genetic spatiotemporal anatomy of plasmodium vivax malaria episodes in Greece, 2009–2013 

      Spanakos G., Snounou G., Pervanidou D., Alifrangis M., Rosanas-Urgell A., Baka A., Tseroni M., Vakali A., Vassalou E., Patsoula E., Zeller H., Van Bortel W., Hadjichristodoulou C., MALWEST Project (2018)
      An influx of immigrants is contributing to the reemergence of Plasmodium vivax malaria in Greece; 1 persistent focus of transmission is in Laconia, Pelopónnese. We genotyped archived blood samples from a substantial ...

    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 

      Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; Van Der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Styrḱarsd́ottir, U.; Tsezou, A.; Van De Putte, T.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; Van Meurs, J. B. J. (2010)
      Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 ...

    • Genomics of habitat choice and adaptive evolution in a deep-sea fish 

      Gaither M.R., Gkafas G.A., De Jong M., Sarigol F., Neat F., Regnier T., Moore D., Gröcke D.R., Hall N., Liu X., Kenny J., Lucaci A., Hughes M., Haldenby S., Hoelzel A.R. (2018)
      Intraspecific diversity promotes evolutionary change, and when partitioned among geographic regions or habitats can form the basis for speciation. Marine species live in an environment that can provide as much scope for ...

    • Identification of Chromosomal Regions Linked to Diabetic Nephropathy: A Meta-Analysis of Genome-Wide Linkage Scans 

      Tziastoudi M., Stefanidis I., Stravodimos K., Zintzaras E. (2019)
      Aims: Diabetic nephropathy (DN) has become a serious public health problem. Genetic factors are involved in the pathogenesis of DN, but the exact mode of inheritance is still unknown. Genome-wide linkage scans (GWLS) have ...

    • Infectomics and autoinfectomics: a tool to study infectious-induced autoimmunity 

      Bogdanos, D. P.; Smyk, D. S.; Rigopoulou, E. I.; Sakkas, L. I.; Shoenfeld, Y. (2015)
      The exposome represents all exogenous and endogenous environmental exposures that begin at preconception and carry on throughout life, while the microbiome reflects the microbial component of the exposome. We recently ...

    • Islands and hybrid zones: Combining the knowledge from "natural Laboratories" to explain phylogeographic patterns of the European brown hare 06 Biological Sciences 0604 Genetics 

      Giannoulis T., Plageras D., Stamatis C., Chatzivagia E., Tsipourlianos A., Birtsas P., Billinis C., Suchentrunk F., Mamuris Z. (2019)
      Background: The aim of the study was to use hybrid populations as well as island populations of the European brown hare (Lepus europaeus) to explore the effect of evolutionary events, such as the post-deglaciation ...

    • Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study 

      Elbaz, A.; Nelson, L. M.; Payami, H.; Ioannidis, J. P.; Fiske, B. K.; Annesi, G.; Carmine Belin, A.; Factor, S. A.; Ferrarese, C.; Hadjigeorgiou, G. M.; Higgins, D. S.; Kawakami, H.; Krüger, R.; Marder, K. S.; Mayeux, R. P.; Mellick, G. D.; Nutt, J. G.; Ritz, B.; Samii, A.; Tanner, C. M.; Van Broeckhoven, C.; Van Den Eeden, S. K.; Wirdefeldt, K.; Zabetian, C. P.; Dehem, M.; Montimurro, J. S.; Southwick, A.; Myers, R. M.; Trikalinos, T. A. (2006)
      Background: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a ...

    • LaGomiCs - Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order 

      Fontanesi L., Di Palma F., Flicek P., Smith A.T., Thulin C.-G., Alves P.C., Abrantes J., Andersson L., Angelone C., Boonstra R., Campos R., Carneiro M., Casadio R., Cervantes F.A., Dahal N., Djan M., Esteves P.J., Etherington G., Fan J., Fickel J., Ge D., Husband T., King T., Kovach A.I., Lavazza A., Letty J., Lissovsky A.A., Mage R., Mamuris Z., Martelli P.L., McGreevy T., Jr., Melo-Ferreira J., Muffato M., Ramakrishnan U., Randi E., Reid N., Ribani A., Robinson T.J., Russello M.A., Schiavo G., Schneider-Gricar V., Solari K.A., Streeter I., Tizzani P., Tur A., Utzeri V.J., Velickovic N., Vernesi C., Yang Q., Lagomorph Genomics Consortium (2016)
      The order Lagomorpha comprises about 90 living species, divided in 2 families: the pikas (Family Ochotonidae), and the rabbits, hares, and jackrabbits (Family Leporidae). Lagomorphs are important economically and scientifically ...

    • Loss of heterozygosity in DNA mismatch repair genes in human atherosclerotic plaques 

      Flouris, G. A.; Arvanitis, D. A.; Parissis, J. T.; Arvanitis, D. L.; Spandidos, D. A. (2001)
      To detect the incidence of loss of heterozygosity (LOH) in DNA mismatch repair genes (MMR) occurring in atherosclerosis, fifty human autopsy cases of atherosclerosis were examined for LOH using 19 microsatellite markers, ...

    • Mitochondrial tRNA mutations: Clinical and functional perturbations 

      Zifa, E.; Giannouli, S.; Theotokis, P.; Stamatis, C.; Mamuris, Z.; Stathopoulos, C. (2007)
      During the last decade, there has been a progressive accumulation of reports that connect the identification of specific mitochondrial tRNA gene mutations to severe disorders in human. As a result, mitochondrial tRNA genes ...

    • Origins and genetic legacy of prehistoric dogs 

      Bergström A., Frantz L., Schmidt R., Ersmark E., Lebrasseur O., Girdland-Flink L., Lin A.T., Storå J., Sjögren K.-G., Anthony D., Antipina E., Amiri S., Bar-Oz G., Bazaliiskii V.I., Bulatović J., Brown D., Carmagnini A., Davy T., Fedorov S., Fiore I., Fulton D., Germonpré M., Haile J., Irving-Pease E.K., Jamieson A., Janssens L., Kirillova I., Horwitz L.K., Kuzmanović-Cvetković J., Kuzmin Y., Losey R.J., Dizdar D.L., Mashkour M., Novak M., Onar V., Orton D., Pasarić M., Radivojević M., Rajković D., Roberts B., Ryan H., Sablin M., Shidlovskiy F., Stojanović I., Tagliacozzo A., Trantalidou K., Ullén I., Villaluenga A., Wapnish P., Dobney K., Götherström A., Linderholm A., Dalén L., Pinhasi R., Larson G., Skoglund P. (2020)
      Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct ...

    • Proteomics challenging medicine 

      Germenis, A. E.; Patrikidou, A. (2005)
      The study of the genome dictated that the whole is more than the sum of its parts; genes do not function independently but in networks. The impact of this understanding was explosive. It acknowledged the concept that this ...

    • Synopsis and Synthesis of Candidate-Gene Association Studies in Chronic Lymphocytic Leukemia: The CUMAGAS-CLL Information System 

      Zintzaras, E.; Kitsios, G. D. (2009)
      A comprehensive and systematic assessment of the current status of candidate-gene association studies for chronic lymphocytic leukemia (CLL) was conducted. Data from 989 candidate-gene association studies (1992-2009) ...

    • Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches 

      Zintzaras, E.; Lau, J. (2008)
      Objective: The aim of the study was to consider statistical and methodological issues affecting the results of meta-analysis of genetic association studies for pertinent gene-disease associations. Although the basic ...

    • Systematic review of pcr proof of parvovirus b19 genomes in endomyocardial biopsies of patients presenting with myocarditis or dilated cardiomyopathy 

      Rigopoulos A.G., Klutt B., Matiakis M., Apostolou A., Mavrogeni S., Noutsias M. (2019)
      Background: Diverse viral infections have been associated with myocarditis (MC) and dilated cardiomyopathy (DCM). In this meta-analysis, we summarize the published results on the association of parvovirus B19 (B19V) genomes ...