Browsing by Subject "animal cell"
Now showing items 1-20 of 27
-
4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects
(2006)In a routine screening of our small-molecule compound collection we recently identified 4-arylazo-3,5-diamino-1H-pyrazoles as a novel group of ATP antagonists with moderate potency against CDK2-cyclin E. A preliminary SAR ... -
Antiparasitic and immunomodulatory effect of innovative treatments against Myxobolus sp. infection in Diplodus puntazzo
(2005)The potential antiparasitic and immunomodulatory effect of three treatments against myxosporean parasites on the innate immune system of sharpsnout sea bream (Diplodus puntazzo) was investigated. Fish naturally infected ... -
Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity
(2007)The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ... -
Bone marrow side population cells are enriched for progenitors capable of myogenic differentiation
(2008)Although the contribution of bone marrow-derived cells to regenerating skeletal muscle has been repeatedly documented, there remains considerable debate as to whether this incorporation is exclusively a result of inflammatory ... -
Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities
(2013)Background: The Y-box protein-1 (YB-1) fulfills pleiotropic functions relating to gene transcription, mRNA processing, and translation. It remains elusive how YB-1 shuttling into the nuclear and cytoplasmic compartments ... -
Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection
(2015)The B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using ... -
Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells
(2010)Breast cancer is the second cause of cancer mortality worldwide in humans and half of all tumours in dogs and there is an unmet need for novel anticancer agents. I have developed a new series of aryl ureido derivatives as ... -
The Developmental Program of Murine Erythroleukemia Cells
(2002)Hematopoietic stem cells (HSCs) or early progenitors respond to external stimuli in bone marrow and differentiate into cell-restricted lineages of blood cells of limited life span. In leukemias, however, early hematopoietic ... -
Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice
(2015)Nearly all vertebrate cells have a single cilium protruding from their surface. This threadlike organelle, once considered vestigial, is now seen as a pivotal element for detection of extracellular signals that trigger ... -
Effect of anoxia and hypoglycaemia on the expression of neuronal cell markers in the rat retina and hippocampus: Development of a rat ex vivo ischemia model
(2007)Neuronal ischemia leads to neuronal cells death due to glucose and oxygen deprivation. The goal of this study was the development of a rat ex vivo ischemia model for the deferential identification of anoxic and hypoglycaemic ... -
Efficacy of an AS03 A-adjuvanted split H5N1 influenza vaccine against an antigenically distinct low pathogenic H5N1 virus in pigs
(2012)We used the pig model of influenza to examine the efficacy of an AS03 A-adjuvanted split H5N1 (A/Indonesia/05/2005) vaccine against challenge with a low pathogenic (LP) H5N1 avian influenza (AI) virus (duck/Minnesota/1525/1981) ... -
Enteroviral infection in Greek AIDS patients
(2004)Objective: Prolonged intestinal replication of polioviruses has not previously been studied in Greek AIDS patients. The objective of our study was to estimate the prevalence of enteroviral infections in this population. ... -
Functional expression of mammalian opioid receptors in insect cells and high-throughput screening platforms for receptor ligand mimetics
(2005)Lepidopteran cell lines have been engineered to constitutively express high levels of mouse δ opioid receptors either alone or in combination with human Gα16 protein. Biochemical and pharmacological studies demonstrate ... -
Genetic polymorphism of canine cytochrome P450 2D25 gene
(2004)Human CYP2D6 is involved in the metabolism of a number of drugs including neuroleptics, tricyclic antidepressants, β-adrenoreceptors antagonists and antiarrhythmic drugs. The corresponding canine CYP2D15 have shown similar ... -
Induced Collagen Cross-Links Enhance Cartilage Integration
(2013)Articular cartilage does not integrate due primarily to a scarcity of cross-links and viable cells at the interface. The objective of this study was to test the hypothesis that lysyl-oxidase, a metalloenzyme that forms ... -
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
(2007)Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ... -
Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates
(1996)Interleukin-2 (IL-2) is the first lymphokine secreted following T cell activation. Several transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT). NFAT acts at the ... -
Mechanisms of action of differentiation inducers: Detection of inducer binding protein(s) in murine erythroleukemia cells
(2005)We have shown previously that murine erythroleukemia (MEL) and human neuroectodermal RD/TE-671 cells are induced to differentiate by ureido derivatives of pyridine (UDPs) and may contain inducer binding protein(s). In the ... -
microTSS: Accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs
(2014)A large fraction of microRNAs (miRNAs) are derived from intergenic non-coding loci and the identification of their promoters remains 'elusive'. Here, we present microTSS, a machine-learning algorithm that provides highly ... -
On the action of the anti-absence drug ethosuximide in the rat and cat thalamus
(1998)The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In ...