Πλοήγηση ανά Θέμα "TNF-ALPHA"

Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease

Gatselis, N. K.; Ntaios, G.; Makaritsis, K.; Dalekos, G. N. (2014)

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has ...

Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis

Stavropoulos-Kalinoglou, A.; Metsios, G. S.; Panoulas, V. F.; Nightingale, P.; Koutedakis, Y.; Kitas, G. D. (2012)

Introduction: Insulin resistance (IR), a risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis (RA). Inflammation, and especially tumour necrosis factor alpha (TNF ...

Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells

Tsapakidis, K.; Vlachostergios, P. J.; Voutsadakis, I. A.; Befani, C. D.; Patrikidou, A.; Hatzidaki, E.; Daliani, D. D.; Moutzouris, G.; Liakos, P.; Papandreou, C. N. (2012)

Objectives: Neuropeptides are important signal initiators in advanced prostate cancer, partially acting through activation of nuclear factor kappa B. Central to nuclear factor kappa B regulation is the ubiquitin-proteasome ...

Cytokine Effects on Cell Viability and Death of Prostate Carcinoma Cells

Chondrogiannis, G.; Kastamoulas, M.; Kanavaros, P.; Vartholomatos, G.; Bai, M.; Baltogiannis, D.; Sofikitis, N.; Arvanitis, D.; Galani, V. (2014)

We analyzed the effects of IL-13, IFN-gamma, and IL-1 beta on cell viability and death of LNCaP and PC-3 cells and major signaling pathways involved in these effects. Significant increase of LNCaP cell death (apoptotic and ...

Cytokine gene polymorphisms in multiple sclerosis: a meta-analysis of 45 studies including 7379 cases and 8131 controls

Nikolopoulos, G. K.; Masgala, A.; Tsiara, C.; Limitsiou, O. K.; Karnaouri, A. C.; Dimou, N. L.; Bagos, P. G. (2011)

Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...

Evaluation of cytokine serum levels in patients with plaque-type psoriasis

Roussaki-Schulze, A. V.; Kouskoukis, C.; Petinaki, E.; Klimi, E.; Zafiriou, E.; Galanos, A.; Rallis, E. (2005)

Psoriasis is a chronic debilitating cutaneous disorder that affects both sexes and appears clinically as inflamed, edematous skin lesions covered with a silvery white scale. Strong evidence suggests that immune mechanisms ...

Quantification of the Effects of Ionic Strength, Viscosity, and Hydrophobicity on Protein-Ligand Binding Affinity

Papaneophytou, C. P.; Grigoroudis, A. I.; McInnes, C.; Kontopidis, G. (2014)

In order to quantify the interactions between molecules of biological interest, the determination of the dissociation constant (K-d) is essential. Estimation of the binding affinity in this way is routinely performed in ...

Regulation of Granulocyte Colony-Stimulating Factor and Its Receptor in Skeletal Muscle Is Dependent Upon the Type of Inflammatory Stimulus

Wright, C. R.; Brown, E. L.; Della Gatta, P. A.; Fatouros, I. G.; Karagounis, L. G.; Terzis, G.; Mastorakos, G.; Michailidis, Y.; Mandalidis, D.; Spengos, K.; Chatzinikolaou, A.; Methenitis, S.; Draganidis, D.; Jamurtas, A. Z.; Russell, A. P. (2015)

The cytokine granulocyte colony-stimulating factor (G-CSF) binds to its receptor (G-CSFR) to stimulate hematopoietic stem cell mobilization, myelopoiesis, and the production and activation of neutrophils. In response to ...

Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis

Wozniak, G.; Toska, A.; Saridi, M.; Mouzas, O. (2011)

Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was ...

Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function

Flouris, A. D.; Metsios, G. S.; Jamurtas, A. Z.; Koutedakis, Y. (2008)

Experimental evidence for the physiological effects of secondhand smoke (SHS) is limited, although it affects millions of people globally and its prevalence is increasing, despite currently adopted antismoking measures. ...

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-alpha/SPD304 Study

Papaneophytou, C. P.; Mettou, A. K.; Rinotas, V.; Douni, E.; Kontopidis, G. A. (2013)

Many active compounds may be excluded from biological assays due to their low aqueous solubility. In this study, a simple method for the determination of the solubility of compounds containing aromatic rings is proposed. ...

A statistical approach for optimization of RANKL overexpression in Escherichia coli: Purification and characterization of the protein

Papaneophytou, C. P.; Rinotas, V.; Douni, E.; Kontopidis, G. (2013)

Receptor activator of nuclear factor-kappa B (RANK) and its cognate ligand (RANICL) is a member of the TNF superfamily of cytokines which is essential in osteobiology and its overexpression has been implicated in the ...