Πλοήγηση ανά Θέμα "T-CELLS"

Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis

Apostolakis, S.; Vlata, Z.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2010)

The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II ...

Autoantibodies to alpha-synuclein in inherited Parkinson's disease

Papachroni, K. K.; Ninkina, N.; Papapanagiotou, A.; Hadjigeorgiou, G. M.; Xiromerisiou, G.; Papadimitriou, A.; Kalofoutis, A.; Buchman, V. L. (2007)

Neurodegeneration in Parkinson's disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that alpha-synuclein is directly implicated in the pathogenesis of PD. Development ...

Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: Implications of the interaction with chemokine receptor CCR5

Morikis, D.; Rizos, A. K.; Spandidos, D. A.; Krambovitis, E. (2007)

Infection of CD4(+) T cells by macrophage-tropic HIV-1 strains involves interaction of viral gp 120 with the host cell chemokine receptor CCR5. The principle neutralizing determinant (PND) of the V3-loop of the HIV-1 gp120 ...

Evidence of HIV-1 gp120/V3-CCR5 peptide complex organization in vitro

Rizos, A. K.; Mpountouraki, A.; Logakh, C.; Samolis, P.; Hatzidakis, G.; Doetschman, D. C.; Krambovitis, E. (2011)

The V3-loop of the HIV-1 envelope glycoprotein gp120 interacts with the chemokine receptor CCR5 on the surface of the target cell. Electrostatic interactions between the electropositive V3-loop and the strongly electronegative ...

Genome-Wide Transcriptomic Analysis of Intestinal Tissue to Assess the Impact of Nutrition and a Secondary Nematode Challenge in Lactating Rats

Athanasiadou, S.; Jones, L. A.; Burgess, S. T. G.; Kyriazakis, I.; Pemberton, A. D.; Houdijk, J. G. M.; Huntley, J. F. (2011)

Background: Gastrointestinal nematode infection is a major challenge to the health and welfare of mammals. Although mammals eventually acquire immunity to nematodes, this breaks down around parturition, which renders ...

Hemodialysis procedure does not affect the levels of sICAM-1 and sVCAM-1 in patients with end stage renal disease

Liakopoulos, V.; Eleftheriadis, T.; Kyropoulos, T.; Voliotis, G.; Potamianos, S.; Zengos, N.; Stefanidis, I.; Heintz, B. (2005)

Atherosclerosis is by far the leading cause of mortality and morbidity in patients with end stage renal disease undergoing chronic hemodialysis (HD). Vascular endothelial cell adhesion molecules like the intercellular ...

HIV-1 infection: Is it time to reconsider our concepts?

Krambovitis, E.; Spandidos, D. A. (2006)

The long asymptomatic phase of HIV infection is critical in the progression to AIDS. It probably reflects an ancestral relationship with lentiviruses stemming from the primate-simian immunodeficiency virus evolutionary ...

Immunoepigenetics: the unseen side of cancer immunoediting

Germenis, A. E.; Karanikas, V. (2007)

Cancer immunosurveillance representing, till recently, the explanatory framework relating cancer and the immune system, does not convincingly explain tumor escape. At the beginning of the decade, a new theory emerged, ...

Intravenous immunoglobulins (IVIG) in systemic sclerosis: a challenging yet promising future

Cantarini, L.; Rigante, D.; Vitale, A.; Napodano, S.; Sakkas, L. I.; Bogdanos, D. P.; Shoenfeld, Y. (2015)

The etiology and pathogenesis of systemic sclerosis are still largely unknown, but a variety of humoral and cellular autoimmune phenomena have been documented. In addition, the rarity of the disease, the broad spectrum of ...

Inverse Association of Serum 25-Hydroxyvitamin D With Markers of Inflammation and Suppression of Osteoclastic Activity in Hemodialysis Patients

Eleftheriadis, T.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I.; Galaktidou, G. (2012)

Introduction. In hemodialysis patients, 25-hydroxyvitamin D conversion to active 1,25-dihydroxyvitamin D by the kidneys is very limited. The expression of both vitamin D receptor and 1 alpha-hydroxylase in cells of the ...

A mathematical model of HIV dynamics in the presence of a rescuing virus with replication deficiency

Zintzaras, E.; Kowald, A. (2011)

Recently, an enzyme (Cre recombinase) has been developed by directed evolution that successfully removes the HIV genome from the nuclear DNA of infected cells. To explore this idea further, we hypothesized that a replication ...

Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients

Passam, A. M.; Sourvinos, G.; Krambovitis, E.; Miyakis, S.; Stavrianeas, N.; Zagoreos, I.; Spandidos, D. A. (2007)

The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to ...

Protein and mRNA expression levels of VEGF-A and TGF-B1 in different types of human coronary atherosclerotic lesions

Panutsopulos, D.; Papalambros, E.; Sigala, F.; Zafiropoulos, A.; Arvanitis, D. L.; Spandidos, D. A. (2005)

It is well documented that inflammation plays a major role in the establishment and progression of atherosclerosis. Endothelial cells, vascular smooth muscle cells and m onocytes/macrophages are involved in this process ...

The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis

Mavropoulos, A.; Rigopoulou, E. I.; Liaskos, C.; Bogdanos, D. P.; Sakkas, L. I. (2013)

The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic ...

Secukinumab in the Treatment of Noninfectious Uveitis: Results of Three Randomized, Controlled Clinical Trials

Dick, A. D.; Tugal-Tutkun, I.; Foster, S.; Zierhut, M.; Liew, S. H. M.; Bezlyak, V.; Androudi, S. (2013)

Purpose: To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis. Design: Three multicenter, ...

A statistical approach for optimization of RANKL overexpression in Escherichia coli: Purification and characterization of the protein

Papaneophytou, C. P.; Rinotas, V.; Douni, E.; Kontopidis, G. (2013)

Receptor activator of nuclear factor-kappa B (RANK) and its cognate ligand (RANICL) is a member of the TNF superfamily of cytokines which is essential in osteobiology and its overexpression has been implicated in the ...

Upregulation of antiphospholipid antibodies following cyclophosphamide therapy in patients with systemic lupus erythematosus

Vlachoyiannopoulos, P. G.; Toya, S. P.; Katsifis, G.; Zintzaras, E.; Tzioufas, A. G.; Moutsopoulos, H. M. (2008)

Objective. We have observed several cases of patients with systemic lupus erythematosus (SLE) who developed antiphospholipid antibodies (aPL) or full blown antiphospholipid syndrome (APS) after being successfully treated ...

The value of serum antilipoarabinomannan antibody detection in the diagnosis of latent tuberculosis in hemodialysis patients

Eleftheriadis, T.; Tsiaga, P.; Antoniadi, G.; Liakopoulos, V.; Kortsaris, A.; Giannatos, E.; Barbutis, K.; Stefanidis, I.; Vargemezis, V. (2005)

Background The risk for tuberculosis (TB) reactivation in hemodialysis (HD) patients is increased, and screening for latent TB is recommended. The tuberculin skin test (TST) is inaccurate because of the high incidence of ...

Whole-blood interferon-gamma assay for the diagnosis of tuberculosis infection in an unselected Greek population

Gerogianni, I.; Papala, M.; Klapsa, D.; Zinzaras, E.; Petinaki, E.; Gourgoulianis, K. I. (2008)

Background and objective: Although QuantiFERON-TB Gold (QFT-G) has been approved for the diagnosis of latent tuberculosis infection (LTBI), there are limited data regarding its performance in routine clinical practice. The ...