Πλοήγηση ανά Συγγραφέα "Stathopoulos, C."

A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme

Vourekas, A.; Kalavrizioti, D.; Zarkadis, I. K.; Spyroulias, G. A.; Stathopoulos, C.; Drainas, D. (2007)

RNase P is an essential and ubiquitous endonuclease that mediates the maturation of the 5' ends of all precursor tRNA molecules. The holoenzyme from Dictyostelium discoideum possesses RNA and protein subunits essential for ...

Asymmetric behavior of archaeal prolyl-tRNA synthetase

Ambrogelly, A.; Kamtekar, S.; Stathopoulos, C.; Kennedy, D.; Söll, D. (2005)

Archaeal prolyl-tRNA synthetases differ from their bacterial counterparts: they contain an additional domain (about 70 amino acids) appended to the carboxy-terminus and lack an editing domain inserted into the class II ...

Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides

Balatsos, N. A. A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C. (2009)

Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of gene expression. ...

Composition of the ribonucleoprotein complex of ribonuclease P from Dictyostelium discoideurn

Vourekas, A.; Kalavrizioti, D.; Theodorakopoulou, O.; Stamatopoulou, V.; Toumpeki, C.; Stathopoulos, C.; Drainas, D. (2006)

Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes

Stagos, D.; Spanou, C.; Margariti, M.; Stathopoulos, C.; Mamuris, Z.; Kazantzoglou, G.; Magiatis, P.; Kouretas, D. (2007)

In the present study, the effects of extracts and polyphenol-rich fractions as well as monomer polyphenols identified in them, from both red and white grapes, on mitomycin C (MMC) induced sister chromatid exchanges (SCEs) ...

Detection of a phylogenetically distinct IMP-type metallo-beta-lactamase, IMP-35, in a CC235 Pseudomonas aeruginosa from the Dutch-German border region (Euregio)

Pournaras, S.; Kock, R.; Mossialos, D.; Mellmann, A.; Sakellaris, V.; Stathopoulos, C.; Friedrich, A. W.; Tsakris, A. (2013)

To characterize a highly divergent IMP-type metallo--lactamase (MBL) variant detected in a multidrug-resistant Pseudomonas aeruginosa clinical isolate. P. aeruginosa isolate 1876 was recovered from an anal swab of an ...

Detection of mutations in the FemXAB protein family in oxacillin-susceptible mecA-positive Staphylococcus aureus clinical isolates

Giannouli, S.; Labrou, M.; Kyritsis, A.; Ikonomidis, A.; Pournaras, S.; Stathopoulos, C.; Tsakris, A. (2010)

Methicillin-resistant Staphylococcus aureus (MRSA) strains that express the mecA gene but are oxacillin susceptible (OS-MRSA; oxacillin MIC < 2 mg/L) are increasingly reported. To gain molecular and functional insights on ...

Differences in biofilm formation and virulence factors between clinical and fecal enterococcal isolates of human and animal origin

Tsikrikonis, G.; Maniatis, A. N.; Labrou, M.; Ntokou, E.; Michail, G.; Daponte, A.; Stathopoulos, C.; Tsakris, A.; Pournaras, S. (2012)

The present study investigated the possible correlation between carriage of the virulence genes esp and fsrb, production of hemolysin and gelatinase and biofilm formation in human vs. animal enterococcal isolates. A ...

Effect of natural nucleotides and their synthetic analogues on mRNA turnover by human poly(A)specific ribonuclease (PARN)

Balatsos, N.; Anastasakis, D.; Maragozidis, P.; Manta, S.; Komiotis, D.; Stathopoulos, C. (2008)

EFFECT OF TRANSOSSEOUS APPLICATION OF LOW-INTENSITY ULTRASOUND AT THE TENDON GRAFT-BONE INTERFACE HEALING: GENE EXPRESSION AND HISTOLOGICAL ANALYSIS IN RABBITS

Papatheodorou, L. K.; Malizos, K. N.; Poultsides, L. A.; Hantes, M. E.; Grafanaki, K.; Giannouli, S.; Ioannou, M. G.; Koukoulis, G. K.; Protopappas, V. C.; Fotiadis, D. I.; Stathopoulos, C. (2009)

The present study investigates the effect of transosseous low-intensity pulsed ultrasound (LiUS) on the healing at tendon graft-bone interface, in molecular and histological level. The anterior cruciate ligament (ACL) in ...

A freestanding proofreading domain is required for protein synthesis quality control in Archaea

Korencic, D.; Ahel, I.; Schelert, J.; Sacher, M.; Ruan, B.; Stathopoulos, C.; Blum, P.; Ibba, M.; Söll, D. (2004)

Threonyl-tRNA synthetase (ThrRS) participates in protein synthesis quality control by selectively editing the misacylated species Ser-tRNAThr. In bacteria and eukaryotes the editing function of ThrRS resides in a highly ...

Genomic analysis of recombinant Sabin clinical isolates

Paximadi, E.; Karakasiliotis, I.; Mamuris, Z.; Stathopoulos, C.; Krikelis, V.; Markoulatos, P. (2006)

Recombination in Poliovirus vaccine strains is a very frequent phenomenon. In this report 23 polio/Sabin strains isolated from healthy vaccinees or from VAPP patients after OPV administration, were investigated in order ...

In Vitro and In Vivo Evaluations of Oxacillin Efficiency against mecA-Positive Oxacillin-Susceptible Staphylococcus aureus

Ikonomidis, A.; Michail, G.; Vasdeki, A.; Labrou, M.; Karavasilis, V.; Stathopoulos, C.; Maniatis, A. N.; Pournaras, S. (2008)

Community-type Staphylococcus aureus strains that are positive for mecA and PBP2a but appear phenotypically susceptible to oxacillin are increasingly reported worldwide. Four S. aureus clinical isolates carrying the mecA ...

Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis

Balatsos, N. A. A.; Anastasakis, D.; Stathopoulos, C. (2009)

Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ...

An Integrated In Silico Approach to Design Specific Inhibitors Targeting Human Poly(A)-Specific Ribonuclease

Vlachakis, D.; Pavlopoulou, A.; Tsiliki, G.; Komiotis, D.; Stathopoulos, C.; Balatsos, N. A. A.; Kossida, S. (2012)

Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human ...

Intensive care unit dissemination of multiple clones of linezolid-resistant Enterococcus faecalis and Enterococcus faecium

Ntokou, E.; Stathopoulos, C.; Kristo, I.; Dimitroulia, E.; Labrou, M.; Vasdeki, A.; Makris, D.; Zakynthinos, E.; Tsakris, A.; Pournaras, S. (2012)

Outbreaks caused by linezolid-resistant (LR) enterococci remain rare. We report the epidemiological and molecular characteristics of the multiclonal dissemination of LR enterococci in the intensive care unit (ICU) of a ...

Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues

Balatsos, N.; Vlachakis, D.; Chatzigeorgiou, V.; Manta, S.; Komiotis, D.; Vlassi, M.; Stathopoulos, C. (2012)

Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease that efficiently degrades poly(A) tails and regulates, in part, mRNA turnover rates. We have previously reported that adenosine- and cytosine-based glucopyranosyl ...