Πλοήγηση ανά Συγγραφέα "Spandidos, D. A."

Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis

Apostolakis, S.; Vlata, Z.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2010)

The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II ...

Applications and Biomonitoring Issues of Recombinant Erythropoietins for Doping Control

Tsitsimpikou, C.; Kouretas, D.; Tsarouhas, K.; Fitch, K.; Spandidos, D. A.; Tsatsakis, A. (2011)

The biochemical actions and side effects of recombinant erythropoietins (rhEPOs), their analogs and mimetics, their misuse as doping agents, and the principal analytical strategies developed to identify them in athletes' ...

Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity

Rizos, A. K.; Baritaki, S.; Tsikalas, I.; Doetschman, D. C.; Spandidos, D. A.; Krambovitis, E. (2007)

The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ...

Confronting multidrug-resistant Acinetobacter baumannii: a review

Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2011)

Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are difficult to treat owing to the extremely limited armamentarium. The present review reports all available treatment options against MDR-AB, including ...

CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: Impact of pre-inflammatory stimuli and renin-angiotensin system modulators

Apostolakis, S.; Krambovitis, E.; Vlata, Z.; Kochiadakis, G. E.; Baritaki, S.; Spandidos, D. A. (2007)

Fractalkine/CX3CR1 pathway is considered a major modulator of atherosclerosis. In the present study, expression of CX3CR1 on PBMCs/monocytes of healthy individuals and coronary artery diseased patients was initially assessed ...

Detection of microsatellite instability in sporadic cardiac myxomas

Sourvinos, G.; Parissis, J.; Sotsiou, F.; Arvanitis, D. L.; Spandidos, D. A. (1999)

Objective: Microsatellite instability (MIN) is an early event in DNA repair-deficient associated diseases and reflects an elevated mutation rate in the genome of neoplastic cells. Sporadic cardiac myxomas are the most ...

Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: Implications of the interaction with chemokine receptor CCR5

Morikis, D.; Rizos, A. K.; Spandidos, D. A.; Krambovitis, E. (2007)

Infection of CD4(+) T cells by macrophage-tropic HIV-1 strains involves interaction of viral gp 120 with the host cell chemokine receptor CCR5. The principle neutralizing determinant (PND) of the V3-loop of the HIV-1 gp120 ...

Evaluation of GenoType Mycobacteria Direct Assay in Comparison with Gen-Probe Mycobacterium tuberculosis Amplified Direct Test and GenoType MTBDRplus for Direct Detection of Mycobacterium tuberculosis Complex in Clinical Samples

Neonakis, I. K.; Gitti, Z.; Baritaki, S.; Petinaki, E.; Baritaki, M.; Spandidos, D. A. (2009)

Three molecular assays were evaluated for the direct detection of Mycobacterium tuberculosis complex bacteria in 125 respiratory and 22 nonrespiratory samples. The overall sensitivities obtained were as follows: GenoType ...

Expression of heregulin in human coronary atherosclerotic lesions

Panutsopulos, D.; Arvanitis, D. L.; Tsatsanis, C.; Papalambros, E.; Sigala, F.; Spandidos, D. A. (2005)

Background: Endothelial cells, monocytes/macrophages, and vascular smooth muscle cells contribute to the establishment and progression of atherosclerotic lesions by expressing growth and inflammatory factors. The aim of ...

Female genital tuberculosis: A review

Neonakis, I. K.; Spandidos, D. A.; Petinaki, E. (2011)

Female genital tuberculosis is an uncommon type of tuberculosis that can lead to infertility. The present review describes the disease, reports available epidemiological data, and focuses on examinations and procedures ...

Geographic variations of human papilloma virus infection and their possible impact on the effectiveness of the vaccination programme

Mammas, I. N.; Vageli, D.; Spandidos, D. A. (2008)

Greece is one of the first countries of the European Union to introduce a human. papilloma virus (HPV) vaccine in its national vaccination programme. Geographical variations in the prevalence of the different HPV types ...

Grape pomace extract exerts antioxidant effects through an increase in GCS levels and GST activity in muscle and endothelial cells

Goutzourelas, N.; Stagos, D.; Housmekeridou, A.; Karapouliou, C.; Kerasioti, E.; Aligiannis, N.; Skaltsounis, A. L.; Spandidos, D. A.; Tsatsakis, A. M.; Kouretas, D. (2015)

In a previous study, we demonstrated that a grape pomace extract (GPE) exerted antioxidant activity in endothelial (EA. hy926) and muscle (C2C12) cells through an increase in glutathione (GSH) levels. In the present study, ...

High-risk human papillomavirus (HPV) in parotid lesions

Vageli, D.; Sourvinos, G.; Ioannou, M.; Koukoulis, G. K.; Spandidos, D. A. (2007)

Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV. We studied 9 ...

The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature

Morou, A. K.; Porichis, F.; Krambovitis, E.; Sourvinos, G.; Spandidos, D. A.; Zafiropoulos, A. (2011)

Background: The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We ...

HIV-1 gp120/V3-derived epitopes promote activation-induced cell death to superantigen-stimulated CD4(+)/CD45RO(+) T cells

Porichis, F.; Vlata, Z.; Hatzidakis, G.; Spandidos, D. A.; Krambovitis, E. (2007)

The third hypervirable (V3) domain of the HIV-1 envelope glycoprotein gp120 has been implicated in HIV pathogenesis via co-receptor usage of chemokine receptors CCR5 and CXCR4. As the protagonist cell populations in the ...

HIV-1 infection: Is it time to reconsider our concepts?

Krambovitis, E.; Spandidos, D. A. (2006)

The long asymptomatic phase of HIV infection is critical in the progression to AIDS. It probably reflects an ancestral relationship with lentiviruses stemming from the primate-simian immunodeficiency virus evolutionary ...

hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment

Vageli, D. P.; Zaravinos, A.; Daniil, Z.; Dahabreh, J.; Doukas, S. G.; Spandidos, D. A.; Gourgoulianis, K. I.; Koukoulis, G. K. (2012)

Background: We recently showed that the mRNA levels of mismatch repair (MMR) proteins in non-small cell lung carcinoma (NSCLC) tissue specimens and the phenotypic translation of molecular MMR data refines the biology of ...