Πλοήγηση ανά Θέμα "SPECT"

Alzheimer's Disease: SPECT and PET Tracers for Beta-Amyloid Imaging

Valotassiou, V.; Archimandritis, S.; Sifakis, N.; Papatriantafyllou, J.; Georgoulias, P. (2010)

The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (A beta) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem ...

Brain Perfusion SPECT with Brodmann Areas Analysis in Differentiating Frontotemporal Dementia Subtypes

Valotassiou, V.; Papatriantafyllou, J.; Sifakis, N.; Tzavara, C.; Tsougos, I.; Psimadas, D.; Kapsalaki, E.; Fezoulidis, I.; Hadjigeorgiou, G.; Georgoulias, P. (2014)

Despite the known validity of clinical diagnostic criteria, significant overlap of clinical symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting in great uncertainty of the diagnostic ...

Clinical Evaluation of Brain Perfusion SPECT with Brodmann Areas Mapping in Early Diagnosis of Alzheimer's Disease

Valotassiou, V.; Papatriantafyllou, J.; Sifakis, N.; Tzavara, C.; Tsougos, I.; Psimadas, D.; Fezoulidis, I.; Kapsalaki, E.; Hadjigeorgiou, G.; Georgoulias, P. (2015)

Early diagnosis of Alzheimer's disease (AD) based on clinical criteria alone may be problematic, while current and future treatments should be administered earlier in order to be more effective. Thus, various disease ...

Evaluation of powder/granular Gd2O2S:Pr scintillator screens in single photon counting mode under 140 keV excitation

David, S.; Georgiou, M.; Loudos, G.; Michail, C.; Fountos, G.; Kandarakis, I. (2013)

The aim of this paper is the evaluation of an alternative, low cost solution for the gamma detector in planar imaging. It is based on a powder scintillator, well established in X-ray imaging, and could be further exploited ...

Experimental and simulation studies for the optimization of dedicated scintimammography cameras

Georgiou, M.; David, S.; Loudos, G.; Tsougos, I.; Georgoulias, P. (2012)

The main drawback of scintimammography with conventional gamma cameras is the large distance between detector and breast, which limits imaging performance and adds significant background noise from the heart and other ...

Optimization of a gamma imaging probe for axillary sentinel lymph mapping

Georgiou, M.; Loudos, G.; Stratos, D.; Papadimitroulas, P.; Liakou, P.; Georgoulias, P. (2012)

Sentinel lymph node (SLN) mapping is a technique for assessing whether early-stage invasive breast cancer has metastasized, thus determining prognosis and treatment options. SLN identification is achieved using the blue-dye ...

Patient-specific internal radionuclide dosimetry

Tsougos, I.; Loudos, G.; Georgoulias, P.; Theodorou, K.; Kappas, C. (2010)

The development of patient-specific treatment planning systems is of outmost importance in the development of radionuclide dosimetry, taking into account that quantitative three-dimensional nuclear medical imaging can be ...

A radionuclide dosimetry toolkit based on material-specific Monte Carlo dose kernels

Loudos, G.; Tsougos, I.; Boukis, S.; Karakatsanis, N.; Georgoulias, P.; Theodorou, K.; Nikita, K.; Kappas, C. (2009)

Objective We sought to develop a user-friendly dosimetry toolkit that should aid the improvement of the quality of radionuclide therapy, which is critically dependent on patient-specific planning of each treatment. Methods ...

Sequence variations in the FII, FV, F13A1, FGB and PAI-1 genes are associated with differences in myocardial perfusion

Satra, M.; Samara, M.; Wosniak, G.; Tzavara, C.; Kontos, A.; Valotassiou, V.; Vamvakopoulos, N. K.; Tsougos, I.; Aleporou-Marinou, V.; Patrinos, G. P.; Kollia, P.; Georgoulias, P. (2011)

Aims: Coronary artery disease (CAD) is a significant cause of morbidity and mortality in modern societies. The association between genetic markers and CAD is still poorly understood. In this study, we evaluated the effect ...

A Swedish family with de novo alpha-synuclein A53T mutation: Evidence for early cortical dysfunction

Puschmann, A.; Ross, O. A.; Vilarino-Guell, C.; Lincoln, S. J.; Kachergus, J. M.; Cobb, S. A.; Lindquist, S. G.; Nielsen, J. E.; Wszolek, Z. K.; Farrer, M.; Widner, H.; van Westen, D.; Hagerstrom, D.; Markopoulou, K.; Chase, B. A.; Nilsson, K.; Reimer, J.; Nilsson, C. (2009)

A de novo alpha-symaclein A53T (p.Ala53 Th; c.209G > A) mutation has been identified in a Swedish family with autosomal dominant Parkinson's disease (PD). Two affected individuals had early-onset (before 31 and 40 years), ...