Πλοήγηση ανά Θέμα "RECEPTOR"

Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis

Apostolakis, S.; Vlata, Z.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2010)

The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II ...

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1 alpha by MAPK

Mylonis, I.; Chachami, G.; Paraskeva, E.; Simos, G. (2008)

Hypoxia-inducible factor 1 (HIF-1) is the key transcriptional activator of hypoxia-inducible genes and an important anti-cancer target. Its regulated subunit, HIF-1 alpha, is controlled by oxygen levels and major signaling ...

Autoimmune hepatitis type 1 and primary biliary cirrhosis have distinct bone marrow cytokine production

Zachou, K.; Rigopoulou, E. I.; Tsikrikoni, A.; Alexandrakis, M. G.; Passam, F.; Kyriakou, D. S.; Stathakis, N. E.; Dalekos, G. N. (2005)

We have recently reported differences in the hematopoiesis between autoimmune hepatitis type I (AIH-1) and primary biliary cirrhosis (PBC). In view of the notion that cytokines are regulators of hematopoiesis, we investigated ...

Complete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinant

Dedepsidis, E.; Pliaka, V.; Kyriakopoulou, Z.; Brakoulias, C.; Levidiotou-Stefanou, S.; Pratti, A.; Mamuris, Z.; Markoulatos, P. (2008)

The genetic properties of strain K/2002, isolated from fecal samples of a 7-month-old child who had received his first oral poliovirus vaccine (OPV) dose at the age of 3 months, are described. Preliminary sequencing ...

Endothelin-1 overexpression: a potential biomarker of unfavorable prognosis in non-metastatic muscle-invasive bladder cancer

Mitrakas, L.; Gravas, S.; Karasavvidou, F.; Dimakopoulos, G.; Moutzouris, G.; Tzortzis, V.; Koukoulis, G.; Papandreou, C.; Melekos, M. (2015)

Endothelin-1 (ET-1) is a multifunctional peptide exerting its effects via receptors A and B. ET-1 and its receptors, endothelin axis (ET axis), play a promoting role in cancer biology. Alterations of proteins of ET axis ...

The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2

Tsianou, D.; Nikolakaki, E.; Tzitzira, A.; Bonanou, S.; Giannakouros, T.; Georgatsou, E. (2009)

SR protein kinases (SRPKs) phosphorylate Ser/Arg dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. Phosphorylation by SRPKs constitutes a major way of regulating such ...

Estradiol and leptin as conditional prognostic IVF markers

Anifandis, G.; Koutselini, E.; Louridas, K.; Liakopoulos, V.; Leivaditis, K.; Mantzavinos, T.; Sioutopoulou, D.; Vamvakopoulos, N. (2005)

We studied the concentration of serum estradiol and serum and follicular fluid leptin in 200 women undergoing their first in vitro fertilization with embryo transfer (IVF-ET) program at the time of human chorionic gonadotrophin ...

Expression of heregulin in human coronary atherosclerotic lesions

Panutsopulos, D.; Arvanitis, D. L.; Tsatsanis, C.; Papalambros, E.; Sigala, F.; Spandidos, D. A. (2005)

Background: Endothelial cells, monocytes/macrophages, and vascular smooth muscle cells contribute to the establishment and progression of atherosclerotic lesions by expressing growth and inflammatory factors. The aim of ...

hTERT regulation by NF-kappa B and c-myc in irradiated HER2-positive breast cancer cells

Papanikolaou, V.; Athanassiou, E.; Dubos, S.; Dimou, I.; Papathanasiou, I.; Kitsiou-Tzeli, S.; Kappas, C.; Tsezou, A. (2011)

Purpose: Telomerase activity (TA), frequently observed in cancer, compensates for telomere shortening thus preventing cell senescence and conferring resistance to therapy. In the present study, we investigated the expression ...

Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo

Tsirmoula, S.; Dimas, K.; Hatziapostolou, M.; Lamprou, M.; Ravazoula, P.; Papadimitriou, E. (2012)

Pleiotrophin (PTN) is a heparin-binding growth factor with diverse functions related to tumor growth, angiogenesis, and metastasis. Pleiotrophin seems to have a significant role in prostate cancer cell growth and to mediate ...

Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee

Fytili, P.; Giannatou, E.; Karachalios, T.; Malizos, K.; Tsezou, A. (2005)

Objective To clarify and evaluate the possible role of interleukin-10G (IL-10G) and interleukin-10R (IL-10R) microsatellite polymorphisms of IL-10 gene in knee osteoarthritis (OA). Methods This was a case-control study. ...

Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNF alpha involvement

Rafail, S.; Ritis, K.; Schaefer, K.; Kourtzelis, I.; Speletas, M.; Doumas, M.; Giaglis, S.; Kambas, K.; Konstantinides, S.; Kartalis, G. (2008)

Introduction: Leptin is an adipocyte-derived cytokine primarily involved in the regulation of body weight and energy balance. In vivo studies suggest that leptin promotes platelet aggregation and thrombosis. Neutrophils ...

Lipopolysaccharide and hypoxia significantly alters interleukin-8 and macrophage chemoattractant protein-1 production by human fibroblasts but not fibrosis related factors

Eleftheriadis, T.; Liakopoulos, V.; Lawson, B.; Antoniadi, G.; Stefanidis, I.; Galaktidou, G. (2011)

Besides extracellular matrix production, fibroblasts are able to produce various cytokines. Their ubiquitous position makes fibroblasts appropriate cells for sensing various noxious stimuli and for attracting immune cells ...

Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human rodent somatic cell hybrid DNA templates

Marcoulatos, P.; Koussidis, G.; Mamuris, Z.; Velissariou, V.; Vamvakopoulos, N. C. (1996)

Interleukin-2 (IL-2) is the first lymphokine secreted following T cell activation, Several transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT), NFAT acts at the ...

MAPPING THE HUMAN CORTICOTROPIN-RELEASING HORMONE-BINDING PROTEIN GENE (CRHBP) TO THE LONG ARM OF CHROMOSOME-5 (5Q11.2-Q13.3)

Vamvakopoulos, N. C.; Sioutopoulou, T. O.; Durkin, S. A.; Nierman, W. C.; Wasmuth, J. J.; McPherson, J. D. (1995)

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Evangelou, E.; Kerkhof, H. J.; Styrkarsdottir, U.; Ntzani, E. E.; Bos, S. D.; Esko, T.; Evans, D. S.; Metrustry, S.; Panoutsopoulou, K.; Ramos, Y. F. M.; Thorleifsson, G.; Tsilidis, K. K.; Arden, N.; Aslam, N.; Bellamy, N.; Birrell, F.; Blanco, F. J.; Carr, A.; Chapman, K.; Day-Williams, A. G.; Deloukas, P.; Doherty, M.; Engstrom, G.; Helgadottir, H. T.; Hofman, A.; Ingvarsson, T.; Jonsson, H.; Keis, A.; Keurentjes, J. C.; Kloppenburg, M.; Lind, P. A.; McCaskie, A.; Martin, N. G.; Milani, L.; Montgomery, G. W.; Nelissen, Rghh; Nevitt, M. C.; Nilsson, P. M.; Ollier, W. E. R.; Parimi, N.; Rai, A.; Ralston, S. H.; Reed, M. R.; Riancho, J. A.; Rivadeneira, F.; Rodriguez-Fontenla, C.; Southam, L.; Thorsteinsdottir, U.; Tsezou, A.; Awallis, G.; Wilkinson, J. M.; Gonzalez, A.; Lane, N. E.; Lohmander, L. S.; Loughlin, J.; Metspalu, A.; Uitterlinden, A. G.; Jonsdottir, I.; Stefansson, K.; Slagboom, P. E.; Zeggini, E.; Meulenbelt, I.; Ioannidis, J. P. A.; Spector, T. D.; van Meurs, J. B. J.; Valdes, A. M.; arc, Ogen Consortium (2014)

Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on ...

The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats

Pitsikas, N.; Markou, A. (2014)

Experimental evidence indicates that the non competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine and the mixed dopamine (DA) D-1/D-2 receptor agonist apomorphine induce schizophrenia-like symptoms in ...