• Alpha-synuclein repeat variants and survival in parkinson's disease 

      Chung, S. J.; Biernacka, J. M.; Armasu, S. M.; Anderson, K.; Frigerio, R.; Aasly, J. O.; Annesi, G.; Bentivoglio, A. R.; Brighina, L.; Chartier-Harlin, M. C.; Goldwurm, S.; Hadjigeorgiou, G.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Krüger, R.; Lesage, S.; Markopoulou, K.; Mellick, G.; Morrison, K. E.; Puschmann, A.; Tan, E. K.; Crosiers, D.; Theuns, J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z. K.; Elbaz, A.; Maraganore, D. M.; Yahalom, G.; Orlev, Y.; Cohen, O. S.; Kozlova, E.; Friedman, E.; Inzelberg, R.; Hassin-Baer, S. (2014)
      Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease ...
    • Assessment of Parkinson's disease risk loci in Greece 

      Kara, E.; Xiromerisiou, G.; Spanaki, C.; Bozi, M.; Koutsis, G.; Panas, M.; Dardiotis, E.; Ralli, S.; Bras, J.; Letson, C.; Edsall, C.; Pliner, H.; Arepalli, S.; Kalinderi, K.; Fidani, L.; Bostantjopoulou, S.; Keller, M. F.; Wood, N. W.; Hardy, J.; Houlden, H.; Stefanis, L.; Plaitakis, A.; Hernandez, D.; Hadjigeorgiou, G. M.; Nalls, M. A.; Singleton, A. B. (2014)
      Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous ...
    • Association between AKT1 gene and Parkinson's disease: A protective haplotype 

      Xiromerisiou, G.; Hadjigeorgiou, G. M.; Papadimitriou, A.; Katsarogiannis, E.; Gourbali, V.; Singleton, A. B. (2008)
      Variation in AKT1 has been associated with schizophrenia, bipolar disease and type 11 diabetes. The aim of the present study was to investigate the potential role of variability within AKT1 as a risk factor for Parkinson's ...
    • Association of paraoxonase 1 gene polymorphisms with risk of Parkinson's disease: a meta-analysis 

      Zintzaras, E.; Hadjigeorgiou, G. M. (2004)
      Paraoxonase1 (PON1) gene polymorphisms were implicated as risk factors for Parkinson's disease (PD), but the results of case-control studies that investigated these associations were controversial. In order to provide an ...
    • Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts 

      Fung, H. C.; Xiromerisiou, G.; Gibbs, J. R.; Wu, Y. R.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Chen, C. M.; Duckworth, J.; Papadimitriou, A.; Tienari, P. J.; Hadjigeorgiou, G. M.; Hardy, J.; Singleton, A. B. (2006)
      Background: The overlap in the clinical and pathological features of tauopathies and synucleinopathies raises the possibility that the tau protein may be important in Parkinson's disease (PD) pathogenesis. Several MAPT ...
    • Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset 

      Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)
      The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...
    • Attractor Divergence as a Metric for Assessing Walking Balance 

      Kurz, M. J.; Markopoulou, K.; Stergiou, N. (2010)
      Individuals with Parkinson's disease and the aged have a high prevalence of falls. Since an increase in the number of falls is associated with physical and psychological harm, it is prudent that biomechanical metrics be ...
    • Autoantibodies to alpha-synuclein in inherited Parkinson's disease 

      Papachroni, K. K.; Ninkina, N.; Papapanagiotou, A.; Hadjigeorgiou, G. M.; Xiromerisiou, G.; Papadimitriou, A.; Kalofoutis, A.; Buchman, V. L. (2007)
      Neurodegeneration in Parkinson's disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that alpha-synuclein is directly implicated in the pathogenesis of PD. Development ...
    • BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups 

      Xiromerisiou, G.; Hadjigeorgiou, G. M.; Eerola, J.; Fernandez, H. H.; Tsimourtou, V.; Mandel, R.; Hellstrom, O.; Gwinn-Hardy, K.; Okun, M. S.; Tienari, P. J.; Singleton, A. B. (2007)
      Experimental and clinical data suggest that genetic variations in brain-derived neurotrophic factor (BDNF) gene may affect risk for Parkinson's disease (PD). We performed a case-control association analysis of BDNF in three ...
    • beta-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease 

      Moraitou, M.; Hadjigeorgiou, G.; Monopolis, I.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Vilageliu, L.; Grinberg, D.; Xiromerisiou, G.; Stefanis, L.; Michelakakis, H. (2011)
      An increasing number of clinical, neuropathological and experimental evidence linking Gaucher disease and a spectrum of synucleinopathies, including Parkinson's disease (PD) has emerged over the last decade. In particular, ...
    • Commercially available sensor-based monitoring and support systems in parkinson's disease: An overview 

      Piromalis D.D., Kokkotis C., Tsatalas T., Bellis G., Tsaopoulos D., Zikos P., Tsotsolas N., Pizanias S., Kounelis M., Hliaoutakis A., Koutsouraki E., Kolovos D.P., Giakas G., Symeonaki E., Papoutsidakis M. (2021)
      Parkinson's disease is a progressive neurodegenerative disorder correlating with dysfunction or deprivation of brains dopaminergic neurons, lack of dopamine, and the formation of abnormal protein particles. There are several ...
    • Evidence of an association between the scavenger receptor class B member 2 gene and Parkinson's disease 

      Michelakakis, H.; Xiromerisiou, G.; Dardiotis, E.; Bozi, M.; Vassilatis, D.; Kountra, P. M.; Patramani, G.; Moraitou, M.; Papadimitriou, D.; Stamboulis, E.; Stefanis, L.; Zintzaras, E.; Hadjigeorgiou, G. M. (2012)
      Lysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose-6-phosphateindependent receptor for glucocerebrosidase ...
    • Genetic and molecular pathogenesis of Parkinson's disease 

      Agorogiannis, E. I.; Agorogiannis, G. I.; Papadimitriou, A.; Hadjigeorgiou, G. M. (2006)
      Parkinson's disease (PD), a common progressive degenerative disease of the central nervous system, affects about 1% of adults aged older than 60 years. PD is characterized by rigidity, tremor, postural instability and ...
    • Genetic assessment of familial and early-onset Parkinson's disease in a Greek population 

      Bozi, M.; Papadimitriou, D.; Antonellou, R.; Moraitou, M.; Maniati, M.; Vassilatis, D. K.; Papageorgiou, S. G.; Leonardos, A.; Tagaris, G.; Malamis, G.; Theofilopoulos, D.; Kamakari, S.; Stamboulis, E.; Hadjigeorgiou, G. M.; Athanassiadou, A.; Michelakakis, H.; Papadimitriou, A.; Gasser, T.; Stefanis, L. (2014)
      Background and purpose Although the first mutation associated with Parkinson's disease (PD) was identified several years ago in the alpha-synuclein (SNCA) gene in families of Greek and Italian ancestry, a more systematic ...
    • The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations 

      Scholz, S. W.; Xiromerisiou, G.; Fung, H. C.; Eerola, J.; Hellstrom, O.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Fernandez, H. H.; Mandel, R.; Okun, M. S.; Gwinn-Hardy, K.; Singleton, A. B. (2006)
      Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share ...
    • In silico study of levodopa in hydrated lipid bilayers at the atomistic level 

      Megariotis G., Romanos N., Avramopoulos A., Mikaelian G., Theodorou D.N. (2021)
      This article presents atomistic molecular dynamics and umbrella sampling simulations of levodopa at various concentrations in hydrated cholesterol-free 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and cholesterol-containing ...
    • The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides 

      Dardiotis, E.; Xiromerisiou, G.; Hadjichristodoulou, C.; Tsatsakis, A. M.; Wilks, M. F.; Hadjigeorgiou, G. M. (2013)
      Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. ...
    • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 

      Krüger, R.; Sharma, M.; Riess, O.; Gasser, T.; Van Broeckhoven, C.; Theuns, J.; Aasly, J.; Annesi, G.; Bentivoglio, A. R.; Brice, A.; Djarmati, A.; Elbaz, A.; Farrer, M.; Ferrarese, C.; Gibson, J. M.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Klein, C.; Lambert, J. C.; Lesage, S.; Lin, J. J.; Lynch, T.; Mellick, G. D.; de Nigris, F.; Opala, G.; Prigione, A.; Quattrone, A.; Ross, O. A.; Satake, W.; Silburn, P. A.; Tan, E. K.; Toda, T.; Tomiyama, H.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Maraganore, D. M. (2011)
      High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...
    • Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: Large-scale collaborative study 

      Evangelou, E.; Maraganore, D. M.; Annesi, G.; Brighina, L.; Brice, A.; Elbaz, A.; Ferrarese, C.; Hadjigeorgiou, G. M.; Krueger, R.; Lambert, J. C.; Lesage, S.; Markopoulou, K.; Mellick, G. D.; Meeus, B.; Pedersen, N. L.; Quattrone, A.; Van Broeckhoven, C.; Sharma, M.; Silburn, P. A.; Tan, E. K.; Wirdefeldt, K.; Ioannidis, J. P. A. (2010)
      Early genome-wide association (GWA) studies on Parkinson's disease (PD) have not been able to yield conclusive, replicable signals of association, perhaps due to limited sample size. We aimed to investigate whether association ...
    • Parkinson's disease and pesticides: Are microRNAs the missing link? 

      Aloizou A.-M., Siokas V., Sapouni E.-M., Sita N., Liampas I., Brotis A.G., Rakitskii V.N., Burykina T.I., Aschner M., Bogdanos D.P., Tsatsakis A., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, ...