Browsing by Subject "PROTEIN"
Now showing items 1-20 of 62
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Activation of mTOR signaling in medullary and aggressive papillary thyroid carcinomas
(2011)Background. Because mammalian target of rapamycin (mTOR) may be involved in thyroid carcinogenesis, we investigated the expression and activation patterns of mTOR signaling proteins in thyroid carcinoma cells and tumors ... -
Alterations of Deadenylase Expression in Acute Leukemias: Evidence for Poly(A)-Specific Ribonuclease as a Potential Biomarker
(2012)Background/Aims: The degradation of mRNA is a key process in the control of gene expression correlated to anomalous cell proliferation. The rate-limiting step of mRNA degradation is the removal of the poly(A) tail by ... -
Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis
(2007)Objective. To address whether or not the rarity of amyloidosis in Greek patients with rheumatoid arthritis (RA) is related to specific alleles of single nucleotide polymorphisms (SNPs) in the 5'-flanking region and the ... -
Anti-Saccharomyces cerevisiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with inflammatory bowel disease
(2001)OBJECTIVES: The combined measurement of perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) and anti-Saccharomyces cerevisiae mannan antibodies (ASCA) has recently been suggested as a valuable diagnostic approach ... -
Anti-survivin antibody responses in lung cancer
(2009)Existing evidence regarding spontaneous anti-survivin humoral responses in lung cancer is inconclusive. Moreover, despite that cancer cell death elicited by radiotherapy and some chemotherapeutic agents seems to be ... -
Association Between the Interleukin-1 beta Gene (IL1B) C-511T Polymorphism and the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Candidate-Gene Association Study
(2014)Variants of the interleukin-1 beta gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B ... -
Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes
(2009)Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ... -
Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population
(2008)Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ... -
Autoantibodies to alpha-synuclein in inherited Parkinson's disease
(2007)Neurodegeneration in Parkinson's disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that alpha-synuclein is directly implicated in the pathogenesis of PD. Development ... -
Bacterial live vaccines with graded level of attenuation achieved by antibiotic resistance mutations: transduction experiments on the functional unit of resistance, attenuation and further accompanying markers
(1998)At least 10% of spontaneous chromosomal antibiotic resistant mutants of bacteria express a strain-dependent graded reduction of virulence; this correlates linearly with a prolonged generation time. Occasionally, these ... -
The C-terminal Region of HPNAP Activates Neutrophils and Promotes Their Adhesion to Endothelial Cells
(2009)Entire Helicobacter Pylori Neutrophil Activated Protein (HPNAP) and its truncated forms NH(2)-terminal region HPNAP(1-57) and C-terminal region HPNAP(58-144) after cloning into pET29c vector, purification and removal of ... -
The canine copper toxicosis gene MURR1 is not implicated in the pathogenesis of Wilson disease
(2006)Background. It has recently been demonstrated that the Wilson disease (WD) protein directly interacts with the human homolog of the MURR1 protein in vitro and in vivo, and that this interaction is specific for the copper ... -
Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
(2012)Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ... -
Changes in feeding behavior as possible indicators for the automatic monitoring of health disorders in dairy cows
(2008)Changes in short-term feeding behavior of dairy cows that occur with the onset of the health disorders ketosis, acute locomotory problems, and chronic lameness were investigated using data collected during previous ... -
Comparing normal primary endocervical adenoepithelial cells to uninfected and influenza B virus infected human cervical adenocarcinoma HeLa cells
(2006)Human adenocarcinoma HeLa cells surviving infection with low (10(-9) units), medium (10(-6) units), and high (10(-2) units) influenza B titers were compared to their uninfected precursors and to normal endocervical ... -
DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs
(2013)Recently, the attention of the research community has been focused on long non-coding RNAs (lncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional ... -
DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions
(2015)microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of ... -
Effect of long-term dietary supplementation with clinoptilolite on performance and selected serum biochemical values in dairy goats
(2009)Objective-To determine the effect of dietary supplementation with clinoptilolite on health and production as well as serum concentrations of fat-soluble vitamins, macroelements and trace elements, and activities of hepatic ... -
The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males
(2006)The purpose of this study was to investigate the effects of a submaximal aerobic exercise bout on adiponectin and resistin levels as well as insulin sensitivity, until 48 h post-exercise in healthy overweight males. Nine ... -
Energetic loads and informational entropy during insect metamorphosis: Measuring structural variability and self-organization
(2011)In this work an information theory approach is presented for measuring structural variability during insect metamorphosis. Following a self-organizational perspective, the underlying assumption is that an insect pupa is a ...