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    • Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index 

      Stolz, D.; Kostikas, K.; Blasi, F.; Boersma, W.; Milenkovic, B.; Lacoma, A.; Louis, R.; Aerts, J. G.; Welte, T.; Torres, A.; Rohde, G. G. U.; Boeck, L.; Rakic, J.; Scherr, A.; Hertel, S.; Giersdorf, S.; Tamm, M. (2014)
      The BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index is well-validated for mortality prediction in chronic obstructive pulmonary disease (COPD). Concentrations of plasma pro-adrenomedullin, a ...

    • Alzheimer's Disease: SPECT and PET Tracers for Beta-Amyloid Imaging 

      Valotassiou, V.; Archimandritis, S.; Sifakis, N.; Papatriantafyllou, J.; Georgoulias, P. (2010)
      The definite diagnosis of Alzheimer's disease (AD) is based on the detection of beta amyloid (A beta) plaques and neurofibrillary tangles (NFTs) - which are the pathological hallmarks of the disease- in the postmortem ...

    • Correlation of Urinary Excretion of Sodium With Severity of Sleep-Disordered Breathing in Children: A Preliminary Study 

      Kaditis, A. G.; Alexopoulos, E. I.; Evangelopoulos, K.; Kostadima, E.; Varlami, V.; Boultadakis, E.; Liakos, N.; Zakynthinos, E.; Zintzaras, E.; Gourgoulianis, K. (2010)
      Background: Nocturnal urinary sodium excretion is related to blood pressure (BP) levels. Elevated BP and increased nocturnal natriuresis have been demonstrated in adults with sleep apnea. Although evidence indicates increased ...

    • Darwinian molecular imaging in nuclear cardiology 

      Georgoulias, P.; Tsougos, I.; Valotassiou, V.; Samara, M.; Kollia, P. (2010)

    • Domestication does not narrow MHC diversity in Sus scrofa 

      Moutou, K. A.; Koutsogiannouli, E. A.; Stamatis, C.; Billinis, C.; Kalbe, C.; Scandura, M.; Mamuris, Z. (2013)
      The Major Histocompatibility Complex (MHC) is a multigene family of outstanding polymorphism. MHC molecules bind antigenic peptides in the peptide-binding region (PBR) that consists of five binding pockets (P). In this ...

    • The effect of estrogens on plasma ghrelin concentrations in women 

      Dafopoulos, K.; Chalvatzas, N.; Kosmas, G.; Kallitsaris, A.; Pournaras, S.; Messinis, I. E. (2010)
      Background: Data regarding the possible effects of estrogen on ghrelin secretion in humans are limited and contradictory. Aim: To investigate the effect of estradiol (E2) on ghrelin levels in normal pre- and post-menopausal ...

    • Effect of Ghrelin and Thyrotropin-releasing Hormone on Prolactin Secretion in Normal Women 

      Messini, C. I.; Dafopoulos, K.; Chalvatzas, N.; Georgoulias, P.; Anifandis, G.; Messinis, I. E. (2010)
      It is known that ghrelin stimulates the secretion of prolactin in women. The aim of this study was to examine the effect of exogenous thyrotropin-releasing hormone (TRH) on ghrelin-induced prolactin release. Ten healthy ...

    • Endothelin-3 and PRL levels in the maternal and fetal circulation at delivery 

      Dafopoulos, K.; Boli, A.; Kallitsaris, A.; Malamitsi-Puchner, A.; Kollios, G.; Messinis, I. E. (2007)
      Objective: The aim of the present cross-sectional study was to test the hypothesis that endothelin-3 (ET-3) is involved in PRL secretion via systemic hormonal interaction during labor. Materials and methods: Fifty healthy ...

    • Low Serum Hepcidin in Patients with Autoimmune Liver Diseases 

      Lyberopoulou, A.; Chachami, G.; Gatselis, N. K.; Kyratzopoulou, E.; Saitis, A.; Gabeta, S.; Eliades, P.; Paraskeva, E.; Zachou, K.; Koukoulis, G. K.; Mamalaki, A.; Dalekos, G. N.; Simos, G. (2015)
      Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin ...

    • Metformin reduces the expression of corticotropin-releasing hormone and urocortin in the endometrium of healthy women 

      Dafopoulos, K.; Vrekoussis, T.; Chalvatzas, N.; Messini, C. I.; Kalantaridou, S. N.; Georgoulias, P.; Messinis, I. E.; Makrigiannakis, A. (2013)
      Objective: To investigate the effect of metformin administration on the expression of endometrial corticotrophin-releasing hormone (CRH) and urocortin (UCN) in the midluteal phase of the cycle. Design: Experimental study, ...

    • Plasma endothelin-1 in hemodialysis treatment - the influence of hypertension 

      Stefanidis, I.; Wurth, P.; Mertens, P. R.; Ikonomov, V.; Philippidis, G.; Golphinopoulos, S.; Makropoulos, V.; Liakopoulos, V.; Mann, H.; Heintz, B. (2004)
      In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and the prevalence of atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide ...

    • Synthesis and Evaluation of Chloramphenicol Homodimers: Molecular Target, Antimicrobial Activity, and Toxicity against Human Cells 

      Kostopoulou, O. N.; Magoulas, G. E.; Papadopoulos, G. E.; Mouzaki, A.; Dinos, G. P.; Papaioannou, D.; Kalpaxis, D. L. (2015)
      As fight against antibiotic resistance must be strengthened, improving old drugs that have fallen in reduced clinical use because of toxic side effects and/or frequently reported resistance, like chloramphenicol (CAM), is ...