Πλοήγηση ανά Θέμα "PATHWAY"
Αποτελέσματα 1-18 από 18
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CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy
(2012)Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-kappa B (NF-kappa B) have been independently associated with prostate cancer (PC) progression. We investigated the correlations ... -
Cytokine Effects on Cell Viability and Death of Prostate Carcinoma Cells
(2014)We analyzed the effects of IL-13, IFN-gamma, and IL-1 beta on cell viability and death of LNCaP and PC-3 cells and major signaling pathways involved in these effects. Significant increase of LNCaP cell death (apoptotic and ... -
The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
(2010)Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ... -
The DJ-1 protein as a candidate biomarker in obstructive sleep apnea syndrome
(2014)Oxidative stress has a central role in the pathophysiology of obstructive sleep apnea syndrome (OSAS). The DJ-1 protein functions as a sensor of oxidative stress, acting both as a reactive oxygen species scavenger (ROS) ... -
Epstein-Barr Virus Immortalization of Human B-Cells Leads to Stabilization of Hypoxia-Induced Factor 1 Alpha, Congruent with the Warburg Effect
(2012)Background: Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in ... -
In vivo induction of the autophagic machinery in human bone marrow cells during Leishmania donovani complex infection
(2009)Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the ... -
Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex
(2008)The catalytic core of methionyl-tRNA synthetase (MetRS) is conserved among all life kingdoms but, depending on species origin, is often linked to noncatalytic domains appended to its N- or C-terminus. These domains usually ... -
Insulin NO-dependent action on airways smooth muscles
(2001)In order to find out how insulin acts on airway smooth muscle and which mechanisms could be involved, we studied the effect of insulin on contraction induced, first, by KCI and, second, by Acetylcholine (Ach), before and ... -
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer
(2011)Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ... -
Molecular determinants of the yeast Arc1p - Aminoacyl-tRNA synthetase complex assembly
(2007)Eukaryotic aminoacyl-tRNA synthetases are usually organized into high-molecular-weight complexes, the structure and function of which are poorly understood. We have previously described a yeast complex containing two ... -
Proliferation and bone marrow engraftment of AML blasts is dependent on beta-catenin signalling
(2011)P>B-catenin is the central effector molecule of the canonical Wnt signalling pathway, which controls self-renewal of haematopoietic stem cells. Deregulation of this pathway occurs in various malignancies including myeloid ... -
Proteomic Studies of Pediatric Medulloblastoma Tumors with 17p Deletion
(2015)CNS tumors are the leading cause of cancer-related death in children. Medulloblastoma is the commonest pediatric CNS malignancy, wherein, despite multimodal therapy with surgery, radiation, and chemotherapy, 5 year survival ... -
Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1 alpha effectors
(2006)Hypoxia inducible factor I (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to develop a simple and genetically tractable in vivo system for HIF-1 ... -
Survivin regulation by HER2 through NF-kappa B and c-myc in irradiated breast cancer cells
(2011)Radiotherapy is an important treatment modality against cancer resulting in apoptosis and inhibition of cell growth. Survivin is an important cancer biomarker conferring to tumour cells increased survival potential by ... -
TACI Expression and Signaling in Chronic Lymphocytic Leukemia
(2015)TACI is a membrane receptor of BAFF and APRIL, contributing to the differentiation and survival of normal B cells. Although malignant B cells are also subjected on TACI signaling, there is a remarkable intradisease and ... -
TNF alpha induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1 alpha transcriptional activity in airway smooth muscle cells
(2013)Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the ... -
The ubiquitin-proteasome system in glioma cell cycle control
(2012)A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes ... -
Using graph theory to analyze biological networks
(2011)Understanding complex systems often requires a bottom-up analysis towards a systems biology approach. The need to investigate a system, not only as individual components but as a whole, emerges. This can be done by examining ...