Όλο το DSpace

Πλοήγηση ανά Θέμα "Osteoarthritis"

Αποτελέσματα 1-20 από 24

    • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes 

      Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)
      Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ...

    • The autophagic response to oxidative stress in osteoarthritic chondrocytes is deregulated 

      Goutas A., Syrrou C., Papathanasiou I., Tsezou A., Trachana V. (2018)
      It has been reported that oxidative stress (OS) is involved in the pathogenesis of osteoarthritis (OA) and that defective autophagy is accompanying this age-related disease. Moreover, it has been proposed that induction ...

    • Better knee function after surgical repair of acute quadriceps tendon rupture in comparison to acute patellar tendon rupture 

      Hantes M.E., Mathews R., Raoulis V., Varitimidis S., Karachalios T., Malizos K.N. (2019)
      Introduction: The purpose of this study was to determine if there is a difference in knee function between patients with quadriceps tendon rupture and patellar tendon rupture after acute surgical repair. Our hypothesis was ...

    • Cholesterol metabolism related genes in osteoarthritis 

      Papathanasiou I., Anastasopoulou L., Tsezou A. (2021)
      Cholesterol homeostasis plays a significant role in skeletal development and the dysregulation of cholesterol-related mechanism has been shown to be involved in the development of cartilage diseases including osteoarthritis ...

    • Chondrocyte protein co-synthesis network analysis links ECM mechanosensing to metabolic adaptation in osteoarthritis 

      Destouni A., Tsolis K.C., Economou A., Papathanasiou I., Balis C., Mourmoura E., Tsezou A. (2021)
      Background: Knee osteoarthritis (OA) is one of the most common structural OA disorders globally. Incomplete understanding of the fundamental biological aspects of osteoarthritis underlies the current lack of effective ...

    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer C.G., Hatzikotoulas K., Southam L., Stefánsdóttir L., Zhang Y., Coutinho de Almeida R., Wu T.T., Zheng J., Hartley A., Teder-Laving M., Skogholt A.H., Terao C., Zengini E., Alexiadis G., Barysenka A., Bjornsdottir G., Gabrielsen M.E., Gilly A., Ingvarsson T., Johnsen M.B., Jonsson H., Kloppenburg M., Luetge A., Lund S.H., Mägi R., Mangino M., Nelissen R.R.G.H.H., Shivakumar M., Steinberg J., Takuwa H., Thomas L.F., Tuerlings M., Loughlin J., Arden N., Birrell F., Carr A., Deloukas P., Doherty M., McCaskie A.W., Ollier W.E.R., Rai A., Ralston S.H., Spector T.D., Wallis G.A., Martinsen A.E., Willer C., Fors E.A., Mundal I., Hagen K., Nilsen K.B., Lie M.U., Børte S., Brumpton B., Nielsen J.B., Fritsche L.G., Zhou W., Heuch I., Storheim K., Tyrpenou E., Koukakis A., Chytas D., Evangelopoulos D.S., Efstathios C., Pneumaticos S., Nikolaou V.S., Malizos K., Anastasopoulou L., Abecasis G., Baras A., Cantor M., Coppola G., Deubler A., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Karalis K., Siminovitch K., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Bai X., Balasubramanian S., Boutkov B., Eom G., Habegger L., Hawes A., Krasheninina O., Lanche R., Mansfield A.J., Maxwell E.K., Nafde M., O'Keeffe S., Orelus M., Panea R., Polanco T., Rasool A., Salerno W., Staples J.C., Li D., Sharma D., Banerjee I., Bovijn J., Locke A., Verweij N., Haas M., Hindy G., De T., Akbari P., Sosina O., Ferreira M.A.R., Jones M.B., Mighty J., LeBlanc M.G., Mitnaul L.J., Babis G.C., Cheung J.P.Y., Kang J.H., Kraft P., Lietman S.A., Samartzis D., Slagboom P.E., Stefansson K., Thorsteinsdottir U., Tobias J.H., Uitterlinden A.G., Winsvold B., Zwart J.-A., Davey Smith G., Sham P.C., Thorleifsson G., Gaunt T.R., Morris A.P., Valdes A.M., Tsezou A., Cheah K.S.E., Ikegawa S., Hveem K., Esko T., Wilkinson J.M., Meulenbelt I., Lee M.T.M., van Meurs J.B.J., Styrkársdóttir U., Zeggini E., arcOGEN Consortium, HUNT All-In Pain, ARGO Consortium, Regeneron Genetics Center (2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

    • Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism 

      Simopoulou, T.; Malizos, K. N.; Iliopoulos, D.; Stefanou, N.; Papatheodorou, L.; Ioannou, M.; Tsezou, A. (2007)
      Objective: To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA). Methods: Messenger RNA (mRNA) expression and protein levels of leptin and leptin's receptor isoforms were ...

    • DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis 

      Papathanasiou I., Trachana V., Mourmoura E., Tsezou A. (2019)
      Aims: Previous studies have demonstrated that transcriptional silencing of miRNAs due to DNA hypermethylation is associated with different pathologies. It has also been reported that abnormal expression of miR-140-5p and ...

    • Factors affecting the quality of life after total knee arthroplasties: a prospective study 

      Papakostidou, I.; Dailiana, Z. H.; Papapolychroniou, T.; Liaropoulos, L.; Zintzaras, E.; Karachalios, T. S.; Malizos, K. N. (2012)
      Background: The purpose of the study is to evaluate the self-reported outcomes in the first year after primary total knee arthroplasty (TKA), and to determine factors influencing the quality of life (QoL) 6 weeks, 3, 6, ...

    • Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes 

      Papathanasiou I., Mourmoura E., Balis C., Tsezou A. (2020)
      Purpose: MiR-146a acts as a negative inflammatory mediator in different diseases and has been implicated in osteoarthritis (OA) pathogenesis. In our study, we investigated the association between miR-SNP rs2910164 and OA ...

    • Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS 

      Mourmoura E., Papathanasiou I., Trachana V., Konteles V., Tsoumpou A., Goutas A., Papageorgiou A.-A., Stefanou N., Tsezou A. (2022)
      Leptin and ROS are implicated in the regulation of inflammatory pathways including NLRP3-inflammasome. We investigated the functional link between leptin, ROS and NLRP3-inflammasome formation/activation in osteoarthritis ...

    • Lipid metabolism and osteoarthritis: Lessons from atherosclerosis 

      Gkretsi, V.; Simopoulou, T.; Tsezou, A. (2011)
      Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of handicap in the Western world. Interestingly, to date, there are neither available biomarkers for early diagnosis of the disease nor ...

    • Long-term follow-up of bucket-handle meniscal repairs: chondroprotective effect outweighs high failure risk 

      Kalifis G., Raoulis V., Panteliadou F., Liantsis A., D’Ambrosi R., Hantes M. (2022)
      Purpose: Outcomes after repair of bucket-handle meniscal tears tend to be satisfying in the short-term follow-up. However, the literature is scarce regarding long-term data following repair of bucket-handle meniscal tears. ...

    • Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via beta-catenin upregulation 

      Gkretsi, V.; Papanikolaou, V.; Dubos, S.; Papathanasiou, I.; Giotopoulou, N.; Valiakou, V.; Wu, C. Y.; Malizos, K. N.; Tsezou, A. (2013)
      Osteoarthritis (OA) is a debilitating disease of the joints characterized by cartilage degradation but to date there is no available pharmacological treatment to inhibit disease progression neither is there any available ...

    • Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury Pathophysiology of musculoskeletal disorders 

      Papathanasiou I., Michalitsis S., Hantes M.E., Vlychou M., Anastasopoulou L., Malizos K.N., Tsezou A. (2016)
      Background: Anterior cruciate ligament (ACL) tear is considered a risk factor for osteoarthritis development. The purpose of our study was to investigate the expression levels of the apoptotic enzyme caspase 3, pro-inflammatory ...

    • MR imaging findings in early osteoarthritis of the knee 

      Karachalios, T.; Zibis, A.; Papanagiotou, P.; Karantanas, A. H.; Malizos, K. N.; Roidis, N. (2004)
      Purpose: To carry out a modern diagnostic survey among patients with a clinical and radiological diagnosis of early osteoarthritis of the knee. Materials and methods:A magnetic resonance imaging survey was performed on 70 ...

    • No difference in osteoarthritis after surgical and non-surgical treatment of ACL-injured knees after 10 years 

      Tsoukas, D.; Fotopoulos, V.; Basdekis, G.; Makridis, K. G. (2015)
      Purpose: Aim of this study was to record and compare the functional and activity level as well as the manifestations of osteoarthritis after isolated ACL ruptures between patients with conservative treatment and ACL ...

    • Osteoarthritis Year in Review 2014: genetics and genomics 

      Tsezou, A. (2014)
      Recent developments in genetics/genomics of osteoarthritis (OA) are discussed to improve our understanding of OA pathophysiology. The discovery of a novel variant near the NCOA3 (nuclear receptor coactivator 3) gene ...

    • Oxidative stress and inflammatory responses following an acute bout of isokinetic exercise in obese women with knee osteoarthritis 

      Germanou, E. I.; Chatzinikolaou, A.; Malliou, P.; Beneka, A.; Jamurtas, A. Z.; Bikos, C.; Tsoukas, D.; Theodorou, A.; Katrabasas, I.; Margonis, K.; Douroudos, I.; Gioftsidou, A.; Fatouros, I. G. (2013)
      Background: Obesity is associated with osteoarthritis and it is accompanied by chronic inflammation and elevated oxidative stress. Strengthening-type exercise is used in knee osteoarthritis (KOA) rehabilitation. This study ...

    • Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium 

      Kerkhof, H. J. M.; Meulenbelt, I.; Akune, T.; Arden, N. K.; Aromaa, A.; Bierma-Zeinstra, S. M. A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S. A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D. J.; Hauksson, V. B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U. M.; Lane, N. E.; Leino-Arjas, P.; Lohmander, L. S.; Luyten, F. P.; Malizos, K. N.; Nakajima, M.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T. D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A. E.; Tsezou, A.; Uchida, A.; Uitterlinden, A. G.; Wilkinson, J. M.; Yoshimura, N.; Valdes, A. M.; van Meurs, J. B. J. (2011)
      Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions ...