Parcourir par sujet "Organic"
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1-(3-Deoxy-3-fluoro-beta-D-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies
(2010)Design of inhibitors of glycogen phosphorylase (GP) with pharmaceutical applications in improving glycaemic control in type 2 diabetes is a promising therapeutic strategy. The catalytic site of muscle glycogen phosphorylase ... -
The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors
(2010)Glycogen phosphorylase (GP) is a promising target for the treatment of type 2 diabetes. In the process of structure based drug design for GP, a group of 15 aromatic aldehyde 4-(beta-D-glucopyranosyl) thiosemicarbazones ... -
Conformational analysis of two novel cytotoxic C2-substituted pyrrolo 2,3-f quinolines in aqueous media, organic solvents, membrane bilayers and at the putative active site
(2012)We have performed: (i) conformational analysis of two novel cytotoxic C2-substituted pyrrolo[2,3-f]quinolines Se and 5g in deuterated dimethylsulfoxide (DMSO-d(6)) utilizing NOE results from NMR spectroscopy; (ii) molecular ... -
Effects of fertilization and salinity on weed flora in common bean (Phaseolus vulgaris L.) grown following organic or conventional cultural practices
(2014)Two field experiments were conducted to assess the effects of cultural system and irrigation water salinity on weed flora in a common bean crop (Phaseolus vulgaris L. cv. Contender). The experiments were designed as split ... -
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents
(2007)1,2:5,6-Di-O-isopropylidene-alpha-D-glucofuranose by the sequence of mild oxidation, reduction, fluorination, periodate oxidation, borohydride reduction, and sulfonylation gave 3-deoxy-3-fluoro-1,2-O-isopropylidene-5-O-p ... -
Exomethylene pyranonucleosides: Efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-D-glycero-hex-3-enopyranosyl)thymine
(2007)A new series of unsaturated pyranonucleosides with an exocyclic methylene group and thymine as heterocyclic base have been designed and synthesized. D-Galactose (1) was readily transformed in three steps into the corresponding ... -
Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N-4-benzoyl cytosine
(2007)1,2:5,6-Di-O-isopropylidene-ot-D-glucofuranose on mild oxidation, reduction, fluorination, and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-D-glueopyranose. This was coupled with silylated ... -
Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase
(2011)Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetylated ... -
Investigation of pulsed electromagnetic field as a novel organic pre-sowing method on germination and initial growth stages of cotton
(2012)Two different pre-sowing techniques have been investigated for their influence in an important industrial plant, namely cotton. Priming methods are very useful for agricultural practices because they improve crop seedling ... -
Magnetic field pre-sowing treatment as an organic friendly technique to promote plant growth and chemical elements accumulation in early stages of cotton
(2013)The enhancement of plant growth using an environmental friendly technique is an absolutely desirable step for modern agriculture. This study reports the positive effect of pulsed electromagnetic field in early growth ... -
Pulsed electromagnetic field: an organic compatible method to promote plant growth and yield in two corn types
(2012)Pre-sowing treatment of pulsed electromagnetic fields was used in corn seeds, in both indoor and outdoor conditions, in order to investigate the effect on plant growth and yield. The results of this research showed that ... -
Relationship between production conditions and milk gross composition in ewe's and goat's organic and conventional farms in central Greece
(2015)Organic milk and dairy products are widely consumed lately, with the belief they are of higher nutritional quality than conventional, while researchers report contradictory views on this issue. This study aimed to compare ... -
Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-D-glucopyranosylamines
(2014)Glycogen phosphorylase (GP) is a validated target for the development of new type 2 diabetes treatments. Exploiting the Zinc docking database, we report the in silico screening of 1888 N-acyl-beta-D-glucopyranosylamines ... -
Trace mineral content of conventional, organic and courtyard eggs analysed by inductively coupled plasma mass spectrometry (ICP-MS)
(2009)We investigated the contents in yolk and albumen of the trace minerals Se, Zn, Mn, Co, Cu, Mo, V, Cr, Ni, TI. As and Cd in eggs from hens from three husbandry systems by ICP-MS. Conventional hens were given a commercial ... -
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation
(2012)Five ribofuranosyl pyrimidine nucleosides and their corresponding 1,2,3-triazole derivatives have been synthesized and characterized. Their inhibitory action to Ribonuclease A has been studied by biochemical analysis and ...