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Sfoglia per Autore "Loughlin, J."

Items 1-20 di 22

    • THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS 

      Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; van Meurs, J.; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J.; Arc, Ogen Consortium (2010)

    • Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies 

      Rodriguez-Fontenla, C.; Calaza, M.; Evangelou, E.; Valdes, A. M.; Arden, N.; Blanco, F. J.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; Esko, T.; Aleta, C. M. G.; Carnota, Jjgr; Helgadottir, H.; Hofman, A.; Jonsdottir, I.; Kerkhof, H. J. M.; Kloppenburg, M.; McCaskie, A.; Ntzani, E. E.; Ollier, W. E. R.; Oreiro, N.; Panoutsopoulou, K.; Ralston, S. H.; Ramos, Y. F.; Riancho, J. A.; Rivadeneira, F.; Slagboom, P. E.; Styrkarsdottir, U.; Thorsteinsdottir, U.; Thorleifsson, G.; Tsezou, A.; Uitterlinden, A. G.; Wallis, G. A.; Wilkinson, J. M.; Zhai, G. J.; Zhu, Y. Y.; Felson, D. T.; Ioannidis, J. P. A.; Loughlin, J.; Metspalu, A.; Meulenbelt, I.; Stefansson, K.; van Meurs, J. B.; Zeggini, E.; Spector, T. D.; Gonzalez, A.; arc, Ogen Consortium (2014)
      Objective. To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods. A total of 199 candidate genes ...

    • ASSOCIATION OF A BMP5 MICROSATELLITE WITH KNEE OSTEOARTHRITIS 

      Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)

    • Association of a BMP5 microsatellite with knee osteoarthritis: case-control study 

      Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
      Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ...

    • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes 

      Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)
      Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ...

    • Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis 

      Kerkhof, H. J. M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Spector, T. D.; Stolk, L.; Tsezou, A.; Uitterlinden, A. G.; Valdes, A. M.; van Meurs, J. B. J. (2010)
      Background: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide ...

    • DEEP SEQUENCING OF GDF5 IN OVER 1900 OSTEOARTHRITIS CASES AND CONTROLS REVEALS NOVEL AND POTENTIALLY FUNCTIONAL RARE VARIANTS IN THE PROTEIN CODING AND PROMOTER REGIONS OF THE GENE 

      Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Gonzalez, A.; Loughlin, J. (2010)

    • Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus 

      Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Reynard, L. N.; Gonzalez, A.; Loughlin, J. (2011)
      Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ...

    • Erratum to A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis [Bone, 44S2 (2009) S224] 

      Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; van der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; van de Putte, T.; Rivadeneira, F.; Slagboom, E. P.; Styrkársdóttir, U.; Tsezou, A.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; van Meurs, J. B. J. (2010)

    • Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis 

      Rodriguez-Lopez, J.; Mustafa, Z.; Pombo-Suarez, M.; Malizos, K. N.; Rego, I.; Blanco, F. J.; Tsezou, A.; Loughlin, J.; Gomez-Reino, J. J.; Gonzalez, A. (2008)
      Objective. Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ...

    • A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis 

      Kerkhof, H. J. M.; Jonsdottir, I.; Meulenbelt, I.; Stolk, L.; Valdes, A. M.; Zhai, G.; Zhu, Y.; Doherty, M.; Doherty, S.; Tsezou, A.; Gonzalez, A.; Carr, A.; Felson, D. T.; Styrkarsdottir, U.; Slagboom, E. P.; Loughlin, J.; Rivadeneira, F.; Hofman, A.; Pols, H. A. P.; Spector, T. D.; Uitterlinden, A. G.; van Meurs, J. B. J. (2009)

    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 

      Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; Van Der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Styrḱarsd́ottir, U.; Tsezou, A.; Van De Putte, T.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; Van Meurs, J. B. J. (2010)
      Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 ...

    • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

      Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
      Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...

    • Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations 

      Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)
      Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...

    • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

      Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
      Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...

    • Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility 

      Meulenbelt, I.; Bos, S. D.; Chapman, K.; van der Breggen, R.; Houwing-Duistermaat, J. J.; Kremer, D.; Kloppenburg, M.; Carr, A.; Tsezou, A.; Gonzalez, A.; Loughlin, J.; Slagboom, E. (2011)
      Objective To study whether common genetic variants of the genes involved in the complex regulatory mechanism determining the intracellular bio-availability of T3 influence osteoarthritis onset. Methods In total 17 genetic ...

    • Meta-analysis of association between the ASPN D-repeat and osteoarthritis 

      Nakamura, T.; Shi, D.; Tzetis, M.; Rodriguez-Lopez, J.; Miyamoto, Y.; Tsezou, A.; Gonzalez, A.; Jiang, Q.; Kamatani, N.; Loughlin, J.; Ikegawa, S. (2007)
      Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ...

    • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility 

      Chapman, K.; Takahashi, A.; Meulenbelt, I.; Watson, C.; Rodriguez-Lopez, J.; Egli, R.; Tsezou, A.; Malizos, K. N.; Kloppenburg, M.; Shi, D. Q.; Southam, L.; van der Breggen, R.; Donn, R.; Qin, J. H.; Doherty, M.; Slagboom, P. E.; Wallis, G.; Kamatani, N.; Jiang, Q.; Gonzalez, A.; Loughlin, J.; Ikegawa, S. (2008)
      We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 ...

    • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 

      Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)
      Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...

    • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip 

      Evangelou, E.; Kerkhof, H. J.; Styrkarsdottir, U.; Ntzani, E. E.; Bos, S. D.; Esko, T.; Evans, D. S.; Metrustry, S.; Panoutsopoulou, K.; Ramos, Y. F. M.; Thorleifsson, G.; Tsilidis, K. K.; Arden, N.; Aslam, N.; Bellamy, N.; Birrell, F.; Blanco, F. J.; Carr, A.; Chapman, K.; Day-Williams, A. G.; Deloukas, P.; Doherty, M.; Engstrom, G.; Helgadottir, H. T.; Hofman, A.; Ingvarsson, T.; Jonsson, H.; Keis, A.; Keurentjes, J. C.; Kloppenburg, M.; Lind, P. A.; McCaskie, A.; Martin, N. G.; Milani, L.; Montgomery, G. W.; Nelissen, Rghh; Nevitt, M. C.; Nilsson, P. M.; Ollier, W. E. R.; Parimi, N.; Rai, A.; Ralston, S. H.; Reed, M. R.; Riancho, J. A.; Rivadeneira, F.; Rodriguez-Fontenla, C.; Southam, L.; Thorsteinsdottir, U.; Tsezou, A.; Awallis, G.; Wilkinson, J. M.; Gonzalez, A.; Lane, N. E.; Lohmander, L. S.; Loughlin, J.; Metspalu, A.; Uitterlinden, A. G.; Jonsdottir, I.; Stefansson, K.; Slagboom, P. E.; Zeggini, E.; Meulenbelt, I.; Ioannidis, J. P. A.; Spector, T. D.; van Meurs, J. B. J.; Valdes, A. M.; arc, Ogen Consortium (2014)
      Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on ...