Πλοήγηση ανά Συγγραφέα "Krambovitis, E."

Angiotensin II up-regulates CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis

Apostolakis, S.; Vlata, Z.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2010)

The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migration has not yet been thoroughly evaluated. Using flow cytometry we assessed the possible effect of angiotensin I and II ...

Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity

Rizos, A. K.; Baritaki, S.; Tsikalas, I.; Doetschman, D. C.; Spandidos, D. A.; Krambovitis, E. (2007)

The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ...

Characterization of the interaction between peptides derived from the gp 120/V3 domain of HIV-1 and the amino terminal of the chemokine receptor CCR5 by NMR spectroscopy and light scattering

Rizos, A. K.; Tsikalas, I.; Morikis, D.; Galanakis, P.; Spyroulias, G. A.; Krambovitis, E. (2006)

We applied static and dynamic light scattering (DLS) to probe the structural and physicochemical determinants of the interaction between the gp120 V3 domain of the human immunodeficiency virus HIV-1 and the amino terminal ...

Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties

Lopez de Victoria, A.; Kieslich, C. A.; Rizos, A. K.; Krambovitis, E.; Morikis, D. (2012)

Background: The V3 loop of the glycoprotein gp120 of HIV-1 plays an important role in viral entry into cells by utilizing as coreceptor CCR5 or CXCR4, and is implicated in the phenotypic tropisms of HIV viruses. It has ...

Conformational properties of HIV-1 gp120/V3 immunogenic domains

Galanakis, P. A.; Spyroulias, G. A.; Rizos, A.; Samolis, P.; Krambovitis, E. (2005)

Infection of target host cells by the human immunodeficiency virus-1 (HIV-1) is a multi-step process involving a series of conformational changes in the viral gp120 and gp41 proteins. Gp120 binding to the main cell receptor, ...

CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: Impact of pre-inflammatory stimuli and renin-angiotensin system modulators

Apostolakis, S.; Krambovitis, E.; Vlata, Z.; Kochiadakis, G. E.; Baritaki, S.; Spandidos, D. A. (2007)

Fractalkine/CX3CR1 pathway is considered a major modulator of atherosclerosis. In the present study, expression of CX3CR1 on PBMCs/monocytes of healthy individuals and coronary artery diseased patients was initially assessed ...

Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: Implications of the interaction with chemokine receptor CCR5

Morikis, D.; Rizos, A. K.; Spandidos, D. A.; Krambovitis, E. (2007)

Infection of CD4(+) T cells by macrophage-tropic HIV-1 strains involves interaction of viral gp 120 with the host cell chemokine receptor CCR5. The principle neutralizing determinant (PND) of the V3-loop of the HIV-1 gp120 ...

Evaluation of Specific Immune Responses to BoNT/A and Tetanus Toxoid in Patients Undergoing Treatment for Neurologic Disorders

Tzagournissakis, M.; Vlata, Z.; Krambovitis, E.; Dolapsakis, G.; Tsatsakis, A. (2012)

Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders

Vlata, Z.; Tsatsakis, A.; Tzagournissakis, M.; Krambovitis, E. (2012)

Botulinum neurotoxins (BoNTs) are used in the treatment of many neurological disorders. The primary structure of BoNTs shows a high degree of homology with the tetanus neurotoxin, the toxoid of which is used as a vaccine. ...

Evidence of HIV-1 gp120/V3-CCR5 peptide complex organization in vitro

Rizos, A. K.; Mpountouraki, A.; Logakh, C.; Samolis, P.; Hatzidakis, G.; Doetschman, D. C.; Krambovitis, E. (2011)

The V3-loop of the HIV-1 envelope glycoprotein gp120 interacts with the chemokine receptor CCR5 on the surface of the target cell. Electrostatic interactions between the electropositive V3-loop and the strongly electronegative ...

The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature

Morou, A. K.; Porichis, F.; Krambovitis, E.; Sourvinos, G.; Spandidos, D. A.; Zafiropoulos, A. (2011)

Background: The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We ...

HIV-1 gp120/V3-derived epitopes promote activation-induced cell death to superantigen-stimulated CD4(+)/CD45RO(+) T cells

Porichis, F.; Vlata, Z.; Hatzidakis, G.; Spandidos, D. A.; Krambovitis, E. (2007)

The third hypervirable (V3) domain of the HIV-1 envelope glycoprotein gp120 has been implicated in HIV pathogenesis via co-receptor usage of chemokine receptors CCR5 and CXCR4. As the protagonist cell populations in the ...

HIV-1 infection: Is it time to reconsider our concepts?

Krambovitis, E.; Spandidos, D. A. (2006)

The long asymptomatic phase of HIV infection is critical in the progression to AIDS. It probably reflects an ancestral relationship with lentiviruses stemming from the primate-simian immunodeficiency virus evolutionary ...

IL-1 cytokines in cardiovascular disease: Diagnostic, prognostic and therapeutic implications

Apostolakis, S.; Vogiatzi, K.; Krambovitis, E.; Spandidos, D. A. (2008)

Interleukins (ILs) are key mediators in the chronic vascular inflammatory response underlying several aspects of cardiovascular disease. Due to their powerful pro-inflammatory potential, and the fact that they are highly ...

K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma

Lyronis, I. D.; Baritaki, S.; Bizakis, I.; Krambovitis, E.; Spandidos, D. A. (2008)

The Ras/Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates including growth, survival and apoptosis. The aim of this study was to determine the incidence of B-raf, Kirsten-ras ...

Miliary tuberculosis with no pulmonary involvement in myelodysplastic syndromes: A curable, yet rarely diagnosed, disease: Case report and review of the literature

Neonakis, I. K.; Alexandrakis, M. G.; Gitti, Z.; Tsirakis, G.; Krambovitis, E.; Spandidos, D. A. (2008)

Background: Although tuberculosis is not uncommon among patients with myelodysplastic syndrome (MDS), only a few reports of such patients suffering from miliary tuberculosis (MT) exist. MT often presents as a fever of ...

Molecular diagnostic tools in mycobacteriology

Neonakis, I. K.; Gitti, Z.; Krambovitis, E.; Spandidos, D. A. (2008)

Although the diagnosis of mycobacteriosis and susceptibility testing are still primarily based on conventional methods (staining, culture, biochemical analysis, proportional method), a series of molecular assays are ...

Mycobacterial species diversity at a general hospital on the island of Crete: First detection of Mycobacterium lentiflavum in Greece

Neonakis, I. K.; Gitti, Z.; Kourbeti, I. S.; Michelaki, H.; Baritaki, M.; Alevraki, G.; Papadomanolaki, E.; Tsafaraki, E.; Tsouri, A.; Baritaki, S.; Krambovitis, E.; Spandidos, D. A. (2007)

The objective of the present study was to investigate the diversity of mycobacterial isolates in a general hospital in Crete, Greece. 48 positive Lowenstein-Jensen cultures over a 3-y period were analysed by means of ...

NMR Evidence of Charge-Dependent Interaction Between Various PND V3 and CCR5 N-Terminal Peptides

Galanakis, P. A.; Kandias, N. G.; Rizos, A. K.; Morikis, D.; Krambovitis, E.; Spyroulias, G. A. (2009)

The third variable (V3) loop is an important region of glycoprotein 120 (gp120) for many biological processes, as it contains the highly conserved GPGR sequence and it represents the binding site for human immunodeficiency ...

Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients

Passam, A. M.; Sourvinos, G.; Krambovitis, E.; Miyakis, S.; Stavrianeas, N.; Zagoreos, I.; Spandidos, D. A. (2007)

The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to ...