Now showing items 1-13 of 13

    • Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population 

      Tsezou, A.; Furuichi, T.; Satra, M.; Makrythanasis, P.; Ikegawa, S.; Malizos, K. N. (2008)
      Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ...
    • Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility 

      Jiang, Q.; Shi, D.; Nakajima, M.; Dai, J.; Wei, J.; Malizos, K. N.; Qin, J.; Miyamoto, Y.; Kamatani, N.; Liu, B.; Tsezou, A.; Nakamura, T.; Ikegawa, S. (2008)
      A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the ...
    • Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations 

      Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)
      Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...
    • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

      Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
      Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...
    • A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis 

      Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Chou, C. H.; Lee, M. T. M.; Hwang, J. Y.; Kim, D. H.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2012)
      Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ...
    • Meta-analysis of association between the ASPN D-repeat and osteoarthritis 

      Nakamura, T.; Shi, D.; Tzetis, M.; Rodriguez-Lopez, J.; Miyamoto, Y.; Tsezou, A.; Gonzalez, A.; Jiang, Q.; Kamatani, N.; Loughlin, J.; Ikegawa, S. (2007)
      Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ...
    • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility 

      Chapman, K.; Takahashi, A.; Meulenbelt, I.; Watson, C.; Rodriguez-Lopez, J.; Egli, R.; Tsezou, A.; Malizos, K. N.; Kloppenburg, M.; Shi, D. Q.; Southam, L.; van der Breggen, R.; Donn, R.; Qin, J. H.; Doherty, M.; Slagboom, P. E.; Wallis, G.; Kamatani, N.; Jiang, Q.; Gonzalez, A.; Loughlin, J.; Ikegawa, S. (2008)
      We have performed a meta-analysis combining data for more than 11 000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 ...
    • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 

      Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)
      Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...
    • New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 

      Nakajima, M.; Takahashi, A.; Kou, I.; Rodriguez-Fontenla, C.; Gomez-Reino, J. J.; Furuichi, T.; Dai, J.; Sudo, A.; Uchida, A.; Fukui, N.; Kubo, M.; Kamatani, N.; Tsunoda, T.; Malizos, K. N.; Tsezou, A.; Gonzalez, A.; Nakamura, Y.; Ikegawa, S. (2010)
      Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through ...
    • Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium 

      Kerkhof, H. J. M.; Meulenbelt, I.; Akune, T.; Arden, N. K.; Aromaa, A.; Bierma-Zeinstra, S. M. A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S. A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D. J.; Hauksson, V. B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U. M.; Lane, N. E.; Leino-Arjas, P.; Lohmander, L. S.; Luyten, F. P.; Malizos, K. N.; Nakajima, M.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T. D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A. E.; Tsezou, A.; Uchida, A.; Uitterlinden, A. G.; Wilkinson, J. M.; Yoshimura, N.; Valdes, A. M.; van Meurs, J. B. J. (2011)
      Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions ...

      Kerkhof, H. J.; Meulenbelt, I.; Arden, N.; Cooper, C.; Doherty, M.; Felson, D.; Gonzalez, A.; Ikegawa, S.; Jiang, Q.; Jonsdottir, I.; Kujala, U.; Lane, N.; Leino-Arjas, P.; Lohmander, S.; Luyten, F.; Nevitt, M.; Slagboom, E.; Spector, T.; Stefansson, K.; Tamm, A.; Tsezou, A.; Wilkinson, J.; Yoshimura, N.; Valdes, A.; van Meurs, J. (2010)
    • Replication studies in various ethnic populations do not support the association of the HIF-2 alpha SNP rs17039192 with knee osteoarthritis 

      Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2011)
    • Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections 

      Dieguez-Gonzalez, R.; Calaza, M.; Shi, D.; Meulenbelt, I.; Loughlin, J.; Tsezou, A.; Dai, J.; Malizos, K. N.; Slagboom, E. P.; Kloppenburg, M.; Chapman, K.; Jiang, Q.; Kremer, D.; Gomez-Reino, J. J.; Nakajima, N.; Ikegawa, S.; Gonzalez, A. (2009)
      Objectives: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). Methods: Five collections ...