Parcourir par auteur "Hatziefthimiou, A."
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Azithromycin reduces the viability of human bronchial smooth muscle cells
Stamatiou, R.; Boukas, K.; Paraskeva, E.; Molyvdas, P. A.; Hatziefthimiou, A. (2010)The macrolide antibiotic azithromycin has an antiproliferative and autophagic effect on rabbit tracheal smooth muscle cells (SMCs). The purpose of this study is to investigate the effect of azithromycin on human bronchial ... -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
Chachami, G.; Simos, G.; Hatziefthimiou, A.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Effectiveness of aldosterone antagonists for preventing atrial fibrillation after cardiac surgery in patients with systolic heart failure: a retrospective study
Simopoulos, V.; Tagarakis, G.; Hatziefthimiou, A.; Skoularigis, I.; Triposkiadis, F.; Trantou, V.; Tsilimingas, N.; Aidonidis, I. (2015)Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery. There exist consistent experimental and clinical data suggesting that aldosterone antagonists (AAs) may exert beneficial effects ... -
Epithelium-dependent regulation of airways smooth muscle function. A histamine nitric oxide pathway
Gourgoulianis, K.; Iliodromitis, Z.; Hatziefthimiou, A.; Molyvdas, P. A. (1998)THE airway epithelium is responsible for the production of a number of arachidonic acid and nonprostanoid inhibitory factors. Epithelium synthesises nitric oxide (NO) which may be important in regulating the function of ... -
Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway
Gourgoulianis, K.; Iliodromitis, C. Z.; Hatziefthimiou, A.; Molyvdas, P. A. (1998)The airway epithelium is responsible for the production of a number of arachidonic acid and non-prostanoid inhibitory factors. Epithelium synthesizes nitric oxide (NO) which may be important in regulating the function of ... -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
Inhaled insulin does not trigger lung inflammation and airway remodelling
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2009) -
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
Papagianni, M.; Hatziefthimiou, A.; Chachami, G.; Gourgoulianis, K.; Molyvdas, P. A.; Paraskeva, E. (2007)Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ... -
Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Vasilaki, A.; Mylonis, I.; Molyvdas, P. A.; Gourgoulianis, K.; Hatziefthimiou, A. (2014)Background: Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on ... -
The mitogenic effect of testosterone and 17 beta-estradiol on airway smooth muscle cells
Stamatiou, R.; Paraskeva, E.; Papagianni, M.; Molyvdas, P. A.; Hatziefthimiou, A. (2011)Airway disease distribution and/or severity exhibit sex differences suggesting that sex hormones are involved in the respiratory system physiology and pathophysiology. The implication of airway smooth muscle cells (ASMCs) ... -
Non-genomic effect of testosterone on airway smooth muscle
Kouloumenta, V.; Hatziefthimiou, A.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A. (2006)Background and purpose: Recent studies on blood vessels have provided evidence that testosterone may exert direct effects on smooth muscle. However, an acute effect on airway reactivity has not been shown yet. The aim of ... -
Ranolazine enhances nicardipine-induced relaxation of alpha1-adrenoceptor-mediated contraction on isolated rabbit aorta
Malavaki, C.; Hatziefthimiou, A.; Daskalopoulou, S. S.; Stefanidis, I.; Karatzaferi, C.; Aidonidis, I. (2015)Ranolazine (RAN) and nicardipine (NIC) have been studied for their vasorelaxing effects but the combination of these agents against adrenergic vasoconstriction has not been tested. The present study aimed at investigating ... -
Ranolazine-Induced Postrepolarization Refractoriness Suppresses Induction of Atrial Flutter and Fibrillation in Anesthetized Rabbits
Aidonidis, I.; Doulas, K.; Hatziefthimiou, A.; Tagarakis, G.; Simopoulos, V.; Rizos, I.; Tsilimingas, N.; Molyvdas, P. A. (2013)Ranolazine (Ran) is a novel anti-ischemic agent with electrophysiologic properties mainly attributed to the inhibition of late Na+ current and atrial-selective early Na+ current. However, there are only limited data regarding ... -
REGIONAL DIFFERENCES IN THE MODULATORY ROLE OF THE EPITHELIUM IN SHEEP AIRWAY
Hatziefthimiou, A.; Kiritsi, M.; Kiropoulou, C.; Vasilaki, A.; Sakellaridis, N.; Molyvdas, P. A. (2009)P>The airway epithelium may modulate smooth muscle responsiveness via the release of biologically active substances, such as nitric oxide (NO) and prostaglandins. Based on regional differences in structure and function ... -
Sexual dimorphism in airway responsiveness to sex hormones in rabbits
Kouloumenta, V.; Hatziefthimiou, A.; Paraskeva, E.; Gourgoulianis, K.; Molyvdas, P. A. (2007) -
STUDY ON THE EFFECT OF PACO(2) ON PULMONARY ARTERY PRESSURE OF MECHANICALLY VENTILATED RABBITS
Triantaris, A.; Makris, D.; Aidonidis, I.; Hatziefthimiou, A.; Zakynthinos, E. (2012) -
TNF alpha induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1 alpha transcriptional activity in airway smooth muscle cells
Tsapournioti, S.; Mylonis, I.; Hatziefthimiou, A.; Ioannou, M. G.; Stamatiou, R.; Koukoulis, G. K.; Simos, G.; Molyvdas, P. A.; Paraskeva, E. (2013)Airway smooth muscle cells (ASMCs) participate in tissue remodeling characteristic of airway inflammatory diseases like asthma. Inflammation and hypoxia pathways are often interconnected and the regulatory subunit of the ...