Πλοήγηση ανά Θέμα "HIF-1 alpha"

Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding

Chachami, G.; Paraskeva, E.; Georgatsou, E.; Bonanou, S.; Simos, G. (2005)

Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ...

Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner

Vlachostergios, P. J.; Hatzidaki, E.; Befani, C. D.; Liakos, P.; Papandreou, C. N. (2013)

Development of drug resistance after standard chemotherapy for glioblastoma multiforme (GBM) with temozolomide (TMZ) is associated with poor prognosis of GBM patients and is at least partially mediated by a direct DNA ...

Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2012)

Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ...

CK1 delta affects cancer cell adaptation to hypoxia by controlling HIF-1 alpha/ARNT complex formation

Kourti, M.; Mylonis, I.; Giakoumakis, N. N.; Ikonomou, G.; Landegren, U.; Lygerou, Z.; Simos, G. (2014)

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

Mylonis, I.; Lakka, A.; Tsakalof, A.; Simos, G. (2010)

Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ...

The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron

Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)

Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ...

High serum levels of HIF-1 alpha in psoriatic patients correlate with an over-expression of IL-6

Vasilopoulos, Y.; Sourli, F.; Zafiriou, E.; Klimi, E.; Ioannou, M.; Mamuris, Z.; Simos, G.; Koukoulis, G.; Roussaki-Schulze, A. (2013)

Angiogenesis has been considered to be an important step in the initiation and progression of chronic diseases such as psoriasis. The hypoxia inducible factor 1 alpha (HIF-1 alpha), a critical hypoxia-induced factor that ...

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in placentae of women with iron deficiency anemia and beta-thalassemia trait

Michalitsi, V.; Dafopoulos, K.; Gourounti, K.; Messini, C.; Ioannou, M.; Christodoulaki, C.; Panagopoulos, P.; Messinis, I. (2015)

Objective: To investigate hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in placentae of women with iron-deficiency anemia and beta-thalassemia trait and to correlate the results with hematological parameters ...

MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity

Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)

HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ...

MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization

Lyberopoulou, A.; Mylonis, I.; Papachristos, G.; Sagris, D.; Kalousi, A.; Befani, C.; Liakos, P.; Simos, G.; Georgatsou, E. (2013)

Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1 alpha, which is inducible by hypoxia and ARNT or HIF-1 beta, which is constitutively expressed. HIF-1 is ...

Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1 alpha effectors

Braliou, G. G.; Venieris, E.; Kalousi, A.; Simos, G. (2006)

Hypoxia inducible factor I (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to develop a simple and genetically tractable in vivo system for HIF-1 ...

Upregulation of VEGF expression is associated with accumulation of HIF-1 alpha in the skin of naive scleroderma patients

Ioannou, M.; Pyrpasopoulou, A.; Simos, G.; Paraskeva, E.; Nikolaidou, C.; Venizelos, I.; Koukoulis, G.; Aslanidis, S.; Douma, S. (2013)

Systemic sclerosis is a disease hallmarked by microangiopathy; the enlargement and leakage of skin capillaries in active stages develops into extensive avascular areas, clinically associated with severe tissue hypoxia and ...

Validated analysis of HIF-1 alpha expression in cancer cells using a controlled and comparative immunoassay

Ioannou, M.; Mylonis, I.; Kouvaras, E.; Papamichali, R.; Daponte, A.; Paraskeva, E.; Simos, G.; Koukoulis, G. K. (2010)

The immunoreactivity of hypoxia inducible factor 1 alpha (HIF-1 alpha) has been considered a reliable indicator of the HIF-1 pathway activation in tissue hypoxia. However, HIF-1 alpha immunoreactivity has been evaluated ...