Πλοήγηση ανά Θέμα "Glucosamine"

Αποτελέσματα 1-2 από 2

High consistency of structure-based design and X-ray crystallography: Design, synthesis, kinetic evaluation and crystallographic binding mode determination of biphenyl-n-acyl-β-d-glucopyranosylamines as glycogen phosphorylase inhibitors

Fischer T., Koulas S.M., Tsagkarakou A.S., Kyriakis E., Stravodimos G.A., Skamnaki V.T., Liggri P.G.V., Zographos S.E., Riedl R., Leonidas D.D. (2019)

Structure-based design and synthesis of two biphenyl-N-acyl-β-D-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical target for type 2 ...
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β- D -Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study

Bokor E., Kyriakis E., Solovou T.G.A., Koppány C., Kantsadi A.L., Szabó K.E., Szakács A., Stravodimos G.A., Docsa T., Skamnaki V.T., Zographos S.E., Gergely P., Leonidas D.D., Somsák L. (2017)

Aryl substituted 1-(β-d-glucosaminyl)-1,2,3-triazoles as well as C-β-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors against muscle and liver isoforms of glycogen phosphorylase (GP). ...