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Browsing by Subject "GENOME-WIDE ASSOCIATION"

Now showing items 1-20 of 31

    • Apolipoprotein E polymorphisms and type 2 diabetes: A meta-analysis of 30 studies including 5423 cases and 8197 controls 

      Anthopoulos, P. G.; Hamodrakas, S. J.; Bagos, P. G. (2010)
      Type 2 diabetes mellitus (T2DM) is a highly complicated metabolic disorder for which there is worldwide effort for the identification of susceptibility genes. Polymorphisms of the Apolipoprotein E (ApoE) gene are associated ...

    • Assessment of gene-by-sex interaction effect on bone mineral density 

      Liu, C. T.; Estrada, K.; Yerges-Armstrong, L. M.; Amin, N.; Evangelou, E.; Li, G.; Minster, R. L.; Carless, M. A.; Kammerer, C. M.; Oei, L.; Zhou, Y. H.; Alonso, N.; Dailiana, Z.; Eriksson, J.; Garcia-Giralt, N.; Giroux, S.; Husted, L. B.; Khusainova, R. I.; Koromila, T.; Kung, A. W.; Lewis, J. R.; Masi, L.; Mencej-Bedrac, S.; Nogues, X.; Patel, M. S.; Prezelj, J.; Richards, J. B.; Sham, P. C.; Spector, T.; Vandenput, L.; Xiao, S. M.; Zheng, H. F.; Zhu, K.; Balcells, S.; Brandi, M. L.; Frost, M.; Goltzman, D.; Gonzalez-Macias, J.; Karlsson, M.; Khusnutdinova, E. K.; Kollia, P.; Langdahl, B. L.; Ljunggren, O.; Lorentzon, M.; Marc, J.; Mellstroem, D.; Ohlsson, C.; Olmos, J. M.; Ralston, S. H.; Riancho, J. A.; Rousseau, F.; Urreizti, R.; Van Hul, W.; Zarrabeitia, M. T.; Castano-Betancourt, M.; Demissie, S.; Grundberg, E.; Herrera, L.; Kwan, T.; Medina-Gomez, C.; Pastinen, T.; Sigurdsson, G.; Thorleifsson, G.; VanMeurs, J. B. J.; Blangero, J.; Hofman, A.; Liu, Y. M.; Mitchell, B. D.; O'Connell, J. R.; Oostra, B. A.; Rotter, J. I.; Stefansson, K.; Streeten, E. A.; Styrkarsdottir, U.; Thorsteinsdottir, U.; Tylavsky, F. A.; Uitterlinden, A.; Cauley, J. A.; Harris, T. B.; Ioannidis, J. P. A.; Psaty, B. M.; Robbins, J. A.; Zillikens, M. C.; VanDuijn, C. M.; Prince, R. L.; Karasik, D.; Rivadeneira, F.; Kiel, D. P.; Cupples, L. A.; Hsu, Y. H. (2012)
      Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects ...

    • Assessment of Parkinson's disease risk loci in Greece 

      Kara, E.; Xiromerisiou, G.; Spanaki, C.; Bozi, M.; Koutsis, G.; Panas, M.; Dardiotis, E.; Ralli, S.; Bras, J.; Letson, C.; Edsall, C.; Pliner, H.; Arepalli, S.; Kalinderi, K.; Fidani, L.; Bostantjopoulou, S.; Keller, M. F.; Wood, N. W.; Hardy, J.; Houlden, H.; Stefanis, L.; Plaitakis, A.; Hernandez, D.; Hadjigeorgiou, G. M.; Nalls, M. A.; Singleton, A. B. (2014)
      Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous ...

    • Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study 

      Ross, O. A.; Soto-Ortolaza, A. I.; Heckman, M. G.; Aasly, J. O.; Abahuni, N.; Annesi, G.; Bacon, J. A.; Bardien, S.; Bozi, M.; Brice, A.; Brighina, L.; Van Broeckhoven, C.; Carr, J.; Chartier-Harlin, M. C.; Dardiotis, E.; Dickson, D. W.; Diehl, N. N.; Elbaz, A.; Ferrarese, C.; Ferraris, A.; Fiske, B.; Gibson, J. M.; Gibson, R.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Klein, C.; Kruger, R.; Kyratzi, E.; Lesage, S.; Lin, C. H.; Lynch, T.; Maraganore, D. M.; Mellick, G. D.; Mutez, E.; Nilsson, C.; Opala, G.; Park, S. S.; Puschmann, A.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Sohn, Y. H.; Stefanis, L.; Tadic, V.; Theuns, J.; Tomiyama, H.; Uitti, R. J.; Valente, E. M.; van de Loo, S.; Vassilatis, D. K.; Vilarino-Guell, C.; White, L. R.; Wirdefeldt, K.; Wszolek, Z. K.; Wu, R. M.; Farrer, M. J.; Genetic Epidemiology Parkinson's, D. (2011)
      Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's ...

    • Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis 

      Kerkhof, H. J. M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Spector, T. D.; Stolk, L.; Tsezou, A.; Uitterlinden, A. G.; Valdes, A. M.; van Meurs, J. B. J. (2010)
      Background: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide ...

    • Evidence of Association Between Methylenetetrahydrofolate Reductase Gene and Susceptibility to Breast Cancer: A Candidate-Gene Association Study in a South-Eastern European Population 

      Papandreou, C. N.; Doxani, C.; Zdoukopoulos, N.; Vlachostergios, P. J.; Hatzidaki, E.; Bakalos, G.; Ziogas, D. C.; Koufakis, T.; Zintzaras, E. (2012)
      The methylenetetrahydrofolate reductase (MTHFR) gene has been proposed as a candidate gene for breast cancer (BC). However, the specific role of MTHFR polymorphisms and haplotypes has not been fully clarified and replicated. ...

    • A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database 

      Zintzaras, E.; Zdoukopoulos, N. (2009)
      In an electronic search of the literature, the authors systematically retrieved all published studies that investigated genetic susceptibility to peripheral arterial disease (PAD). They created a comprehensive database of ...

    • Field Synopsis and Synthesis of Genetic Association Studies in Osteoarthritis: The CUMAGAS-OSTEO Information System 

      Zintzaras, E.; Kitsios, G. D.; Ziogas, D. C.; Rodopoulou, P.; Karachalios, T. (2010)
      A comprehensive and systematic assessment of the current status of genetic association studies (GAS) for osteoarthntis was conducted. Data from 327 GAS involving 187 distinct genetic variants were analyzed and cataloged ...

    • Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis 

      Zintzaras, E. (2012)
      Objectives The available evidence from the genetic association studies (GAS) published to date on the association between variants in the GABRA2 gene and alcoholism has produced inconclusive results. To interpret these ...

    • Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies 

      Zintzaras, E. (2010)
      A synopsis and meta-analysis of studies that investigated the association between genetic variants involved in the homocysteine/folate metabolism pathway and risk of inflammatory bowel disease (IBD) were conducted. Four ...

    • HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction 

      Vasilopoulos, Y.; Sagoo, G. S.; Cork, M. J.; Walters, K.; Tazi-Ahnini, R. (2011)
      Psoriasis is an inflammatory skin disorder that exhibits multifactorial mode of inheritance. In addition to the well-known susceptibility locus PSORS1 many other loci have been shown to be implicated in the genetic ...

    • HOW CAN BIOINFORMATICS AND TOXICOGENOMICS ASSIST THE NEXT GENERATION OF RESEARCH ON PHYSICAL EXERCISE AND ATHLETIC PERFORMANCE 

      Kerksick, C. M.; Tsatsakis, A. M.; Hayes, A. W.; Kafantaris, I.; Kouretas, D. (2015)
      The past 2-3 decades have seen an explosion in analytical areas related to "omic" technologies. These advancements have reached a point where their application can be and are being used as a part of exercise physiology and ...

    • Individualization of chronic hepatitis C treatment according to the host characteristics 

      Gatselis, N. K.; Zachou, K.; Saitis, A.; Samara, M.; Dalekos, G. N. (2014)
      Hepatitis C virus (HCV) infection is a global health problem that affects more than 170 million people worldwide. It is a major cause of cirrhosis and hepatocellular carcinoma, making the virus the most common cause of ...

    • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

      Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
      Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...

    • Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism? 

      Zintzaras, E. (2011)
      Objectives The available published evidence from the genetic association studies on the association between alcoholism and catechol-O-methyl transferase 472G/A gene polymorphism have produced inconclusive results. To ...

    • Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease? 

      Zintzaras, E. (2012)
      Background: Inflammatory bowel disease (IBD) is a complex disease with a genetic background. Crohn's disease (CD) and ulcerative colitis (UC) are the two main types of IBD. There is indication that variants in the MDR1 ...

    • A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis 

      Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Chou, C. H.; Lee, M. T. M.; Hwang, J. Y.; Kim, D. H.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2012)
      Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ...

    • Meta-Analysis of Family-Based and Case-Control Genetic Association Studies that Use the Same Cases 

      Bagos, P. G.; Dimou, N. L.; Liakopoulos, T. D.; Nikolopoulos, G. K. (2011)
      In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ...

    • A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants 

      Sharma, M.; Ioannidis, J. P. A.; Aasly, J. O.; Annesi, G.; Brice, A.; Bertram, L.; Bozi, M.; Barcikowska, M.; Crosiers, D.; Clarke, C. E.; Facheris, M. F.; Farrer, M.; Garraux, G.; Gispert, S.; Auburger, G.; Vilarino-Guell, C.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Jeon, B. S.; Jamrozik, Z.; Krygowska-Wajs, A.; Lesage, S.; Lill, C. M.; Lin, J. J.; Lynch, T.; Lichtner, P.; Lang, A. E.; Libioulle, C.; Murata, M.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Meitnger, T.; Zimprich, A.; Opala, G.; Pramstaller, P. P.; Pichler, I.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Satake, W.; Silburn, P. A.; Strom, T. M.; Theuns, J.; Tan, E. K.; Toda, T.; Tomiyama, H.; Uitti, R. J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yomono, H. S.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D.; Kruger, R.; Consortium, Geopd (2012)
      Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease. Although additional missense variants were described, ...

    • A Multipoint Method for Meta-Analysis of Genetic Association Studies 

      Bagos, P. G.; Liakopoulos, T. D. (2010)
      Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ...