Πλοήγηση ανά Θέμα "Biophysics"
Αποτελέσματα 1-20 από 39
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Abnormal serum concentrations of proteins in Parkinson's disease
(2009)Blood serum was used to identify protein biomarkers for diagnosis of Parkinson's disease (PD) using analytically validated quantitative 2D-gel electrophoresis, and single variable and multivariate statistics. Using banked ... -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
(2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Biophysical characterization of V3-lipopeptide liposomes influencing HIV-1 infectivity
(2007)The V3-loop of the HIV-1 gp120 alters host cell immune function and modulates infectivity. We investigated biophysical parameters of liposome constructs with embedded lipopeptides from the principle neutralizing domain of ... -
Blood as a reactive species generator and redox status regulator during exercise
(2009)The exact origin of reactive species and oxidative damage detected in blood is largely unknown. Blood interacts with all organs and tissues and, consequently, with many possible sources of reactive species. In addition, a ... -
Building arks for tRNA: Structure and function of the Arc1p family of non-catalytic tRNA-binding proteins
(2010)Following the intricate architecture of the eukaryotic cell, protein synthesis involves formation of many macromolecular assemblies, some of which are composed by tRNA-aminoacylation enzymes. Protein-protein and protein-tRNA ... -
Changes in the level of poly(Phe) synthesis in Escherichia coli ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus can be explained by structural changes in the peptidyltransferase center: a molecular dynamics simulation analysis
(2006)Data from polyphenylalanine [poly(Phe)] synthesis determination in the presence and in the absence of erythromycin have been used in conjunction with Molecular Dynamics Simulation analysis, in order to localize the functional ... -
Classification of pathological human brain lesions using magnetic resonance spectroscopy at 3T
(2009)Magnetic Resonance Spectroscopy is a powerful non-invasive diagnostic tool that is used in conjunction with MRI techniques to provide identification and quantification of biologically important compounds in soft tissue. ... -
Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties
(2012)Background: The V3 loop of the glycoprotein gp120 of HIV-1 plays an important role in viral entry into cells by utilizing as coreceptor CCR5 or CXCR4, and is implicated in the phenotypic tropisms of HIV viruses. It has ... -
Computer simulation based selection of optimal monomer for imprinting of tri-O-acetiladenosine in polymer matrix: vacuum calculations
(2013)Molecularly imprinted polymers can be anticipated as synthetic imitation of natural antibodies, receptors and enzymes. In case of successful imprinting the selectivity and affinity of the imprint for substrate molecules ... -
The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
(2010)Hepatocellular carcinoma (HCC) is characterized by high mortality rates and resistance to conventional treatment. HCC tumors usually develop local hypoxia, which stimulates proliferation of cancer cells and renders them ... -
Dose calculation optimization in intracranial stereotactic radiotherapy using implicit surface modeling
(2009)Intracranial Stereotactic radiotherapy / radiosurgery utilize fractioned dose delivery through multiple noncoplanar arcs to avoid harm of normal tissue. Proper positioning of the arcs in respect to avoid Organs at Risk ... -
Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: Implications on hydrolysis of expanded-spectrum cephalosporins
(2011)CMY-30, a naturally occurring class C beta-lactamase differing from the Citrobacter freundii-derived CMY-2 by a Val211Gly substitution in the X-loop, exhibits increased hydrolytic efficiency against ceftazidime and cefotaxime. ... -
Finite element simulation of the mechanical impact of computer work on the carpal tunnel syndrome
(2014)Carpal tunnel syndrome (CTS) is a clinical disorder resulting from the compression of the median nerve. The available evidence regarding the association between computer use and CTS is controversial. There is some evidence ... -
Frequency content asymmetry of the isokinetic curve between ACL deficient and healthy knee
(2004)The torque-time curve patterns of concentric isokinetic knee extension in anterior cruciate ligament (ACL) deficient patients usually present mid-range irregularities associated with the level of anterior tibial translation. ... -
hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies
(2012)Human coilin interacting nuclear ATPase protein (hCINAP) directly interacts with coilin, a marker protein of Cajal Bodies (CBs), nuclear organelles involved in the maturation of small nuclear ribonucleoproteins UsnRNPs and ... -
HMMpTM: Improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction
(2014)During the last two decades a large number of Computational methods have been developed for predicting transmembrane protein topology. Current predictors rely on topogenic signals in the protein sequence, such as the ... -
Incorporating prey refuge in a prey-predator model with a Holling type I functional response: random dynamics and population outbreaks
(2013)A prey-predator discrete-time model with a Holling type I functional response is investigated by incorporating a prey refuge. It is shown that a refuge does not always stabilize prey-predator interactions. A prey refuge ... -
Inhibitor design for ribonuclease A: the binding of two 5 '-phosphate uridine analogues
(2009)In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5'-phosphate (U5P) and uridine 5'-diphosphate ... -
Investigation of pulsed electromagnetic field as a novel organic pre-sowing method on germination and initial growth stages of cotton
(2012)Two different pre-sowing techniques have been investigated for their influence in an important industrial plant, namely cotton. Priming methods are very useful for agricultural practices because they improve crop seedling ...