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Browsing by Subject "translation regulation"

Now showing items 1-3 of 3

    • Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC) 

      Balatsos, N. A. A.; Nilsson, P.; Mazza, C.; Cusack, S.; Virtanen, A. (2006)
      Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3′-exoribonuclease. Here we have investigated how the cap binding complex (CBC) affects human PARN activity. We showed that CBC, via its 80-kDa ...

    • mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival 

      Lambrianidou A., Sereti E., Soupsana K., Komini C., Dimas K., Trangas T. (2021)
      mTORC2 promotes cell survival by phosphorylating AKT and enhancing its activity. Inactivation of mTORC2 reduces viability through down-regulation of E2F1 caused by up-regulation of c-MYC. An additional target of mTORC2 is ...

    • Parkinson's disease and pesticides: Are microRNAs the missing link? 

      Aloizou A.-M., Siokas V., Sapouni E.-M., Sita N., Liampas I., Brotis A.G., Rakitskii V.N., Burykina T.I., Aschner M., Bogdanos D.P., Tsatsakis A., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, ...