Auflistung Nach Schlagwort "substitution reaction"

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The association between nurse staffing and inpatient mortality: A shift-level retrospective longitudinal study

Musy S.N., Endrich O., Leichtle A.B., Griffiths P., Nakas C.T., Simon M. (2021)

Background: Worldwide, hospitals face pressure to reduce costs. Some respond by working with a reduced number of nurses or less qualified nursing staff. Objective: This study aims at examining the relationship between ...
Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Chetter B.A., Kyriakis E., Barr D., Karra A.G., Katsidou E., Koulas S.M., Skamnaki V.T., Snape T.J., Psarra A.-M.G., Leonidas D.D., Hayes J.M. (2020)

Glycogen phosphorylase (GP) is an important target for the development of new anti-hyperglycaemic agents. Flavonoids are novel inhibitors of GP, but their mode of action is unspecific in terms of the GP binding sites ...