Sfoglia per Soggetto "protein expression level"

Anti-apoptotic and antioxidant activities of the mitochondrial estrogen receptor beta in n2a neuroblastoma cells

Tsialtas I., Georgantopoulos A., Karipidou M.E., Kalousi F.D., Karra A.G., Leonidas D.D., Psarra A.-M.G. (2021)

Estrogens are steroid hormones that play a crucial role in the regulation of the reproductive and non-reproductive system physiology. Among non-reproductive systems, the nervous system is mainly affected by estrogens due ...

COVID-19 and human reproduction: A pandemic that packs a serious punch

Anifandis G., Tempest H.G., Oliva R., Swanson G.M., Simopoulou M., Easley C.A., Primig M., Messini C.I., Turek P.J., Sutovsky P., Ory S.J., Krawetz S.A. (2021)

The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively ...

Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders

Miliotou A.N., Pappas I.S., Spyroulias G., Vlachaki E., Tsiftsoglou A.S., Vizirianakis I.S., Papadopoulou L.C. (2021)

The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the ...

Dysregulation of caveolin-1 phosphorylation and nuclear translocation is associated with senescence onset

Goutas A., Outskouni Z., Papathanasiou I., Satra M., Koliakos G., Trachana V. (2021)

We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status ...

Editorial: Physiological response to environmental stressors in invertebrates

Adamski Z., Ntalli N., Słocińska M., Scrano L. (2022)

[No abstract available]

The expression of myeloproliferative neoplasm-associated calreticulin variants depends on the functionality of er-associated degradation

Mansier O., Prouzet-Mauléon V., Jégou G., Barroso K., Pelizzari Raymundo D., Chauveau A., Pierre-Yves D., Lagarde V., Turcq B., Jean-Max P., Jean-François V., James C., Praloran V., Voutetakis K., Chatziioannou A., François-Xavier M., Chevet E., Lippert E. (2019)

Background: Mutations in CALR observed in myeloproliferative neoplasms (MPN) were recently shown to be pathogenic via their interaction with MPL and the subsequent activation of the Janus Kinase – Signal Transducer and ...

Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation under Low Oxygen

Chachami G., Stankovic-Valentin N., Karagiota A., Basagianni A., Plessmann U., Urlaub H., Melchior F., Simos G. (2019)

Hypoxia occurs in pathological conditions, such as cancer, as a result of the imbalance between oxygen supply and consumption by proliferating cells. HIFs are critical molecular mediators of the physiological response to ...

Hypoxia-Inducible Factor-2-Altered Urothelial Carcinoma: Clinical and Genomic Features

Vlachostergios P.J., Tamposis I.A., Anagnostou M., Papathanassiou M., Mitrakas L., Zachos I., Thodou E., Samara M., Tzortzis V. (2022)

Background: Hypoxia is recognized as a key feature of cancer growth and is involved in various cellular processes, including proliferation, angiogenesis, and immune surveillance. Besides hypoxia-inducible factor 1-alpha ...

Low-Grade Systemic Inflammation Interferes with Anabolic and Catabolic Characteristics of the Aged Human Skeletal Muscle

Draganidis D., Jamurtas A.Z., Chondrogianni N., Mastorakos G., Jung T., Grune T., Papadopoulos C., Papanikolaou K., Papassotiriou I., Papaevgeniou N., Poulios A., Batrakoulis A., Deli C.K., Georgakouli K., Chatzinikolaou A., Karagounis L.G., Fatouros I.G. (2021)

Aging is associated with the development of chronic low-grade systemic inflammation (LGSI) characterized by increased circulating levels of proinflammatory cytokines and acute phase proteins such as C-reactive protein ...

Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity

Karagiota A., Mylonis I., Simos G., Chachami G. (2019)

Hypoxia-inducible factors (HIF) are master regulators of the response to hypoxia. Although several kinases are known to modify their oxygen sensitive HIF-α subunits or affect indirectly their function, little is known about ...

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Verginadis I.I., Avgousti H., Monslow J., Skoufos G., Chinga F., Kim K., Leli N.M., Karagounis I.V., Bell B.I., Velalopoulou A., Salinas C.S., Wu V.S., Li Y., Ye J., Scott D.A., Osterman A.L., Sengupta A., Weljie A., Huang M., Zhang D., Fan Y., Radaelli E., Tobias J.W., Rambow F., Karras P., Marine J.-C., Xu X., Hatzigeorgiou A.G., Ryeom S., Diehl J.A., Fuchs S.Y., Puré E., Koumenis C. (2022)

Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples cell growth and survival ...