Tutto DSpace

Sfoglia per Soggetto "maximum plasma concentration"

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    • Bioavailability, Efficacy and Safety of Generic Immunosuppressive Drugs for Kidney Transplantation: A Systematic Review and Meta-Analysis 

      Tsipotis E., Gupta N.R., Raman G., Zintzaras E., Jaber B.L. (2016)
      Background: Concerns exist over the extrapolation of bioavailability studies of generic immunosuppressive drugs in healthy volunteers, regarding their efficacy and safety in kidney transplant recipients. We conducted a ...

    • Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors 

      Wang, S.; Midgley, C. A.; Scaërou, F.; Grabarek, J. B.; Griffiths, G.; Jackson, W.; Kontopidis, G.; McClue, S. J.; McInnes, C.; Meades, C.; Mezna, M.; Plater, A.; Stuart, I.; Thomas, M. P.; Wood, G.; Clarke, R. G.; Blake, D. G.; Zheleva, D. I.; Lane, D. P.; Jackson, R. C.; Glover, D. M.; Fischer, P. M. (2010)
      Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitotic ...

    • Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy 

      Pölzl G., Altenberger J., Baholli L., Beltrán P., Borbély A., Comin-Colet J., Delgado J.F., Fedele F., Fontana A., Fruhwald F., Giamouzis G., Giannakoulas G., Garcia-González M.J., Gustafsson F., Kaikkonen K., Kivikko M., Kubica J., von Lewinski D., Löfman I., Malfatto G., Manito N., Martínez-Sellés M., Masip J., Merkely B., Morandi F., Mølgaard H., Oliva F., Pantev E., Papp Z., Perna G.P., Pfister R., Piazza V., Bover R., Rangel-Sousa D., Recio-Mayoral A., Reinecke A., Rieth A., Sarapohja T., Schmidt G., Seidel M., Störk S., Vrtovec B., Wikström G., Yerly P., Pollesello P. (2017)
      Patients in the latest stages of heart failure are severely compromised, with poor quality of life and frequent hospitalizations. Heart transplantation and left ventricular assist device implantation are viable options ...