Parcourir par sujet "linkage"
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Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis
(2006)Osteoarthritis (OA) is a common age-related debilitating disease of the joints characterized by degeneration of the articular cartilage which leads to joint pain, discomfort, and immobility. Several risk factors have been ... -
Genomic Convergence of Genome-wide Investigations for Complex Traits
(2009)Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ... -
Heterogeneity testing in meta-analysis of genome searches
(2005)Genome searches for identifying susceptibility loci for the same complex disease often give inconclusive or inconsistent results. Genome Search Meta-analysis (GSMA) is an established non-parametric method to identify genetic ... -
A heterogeneity-based genome search meta-analysis for autism-spectrum disorders
(2006)Autism and autism-spectrum disorders exhibit high heritability, although specific susceptibility genes still remain largely elusive. We performed a heterogeneity-based genome search meta-analysis (HEGESMA) of nine genome ... -
Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
(2007)Introduction: BMD is a heritable trait and an important predictor of osteoporotic fracture risk. Several genome-wide scans have been performed in an attempt to detect loci that regulate BMD, but there has been limited ... -
A Multipoint Method for Meta-Analysis of Genetic Association Studies
(2010)Meta-analyses of genetic association studies are usually performed using a single polymorphism at a time, even though in many cases the individual studies report results from partially overlapping sets of polymorphisms. ...